... ; Perez-Vale et al., 2023 ). The central PDZ domain binds several partners, including the transmembrane junctional proteins E-cadherin (Ecad; Sawyer et al., 2009 ) and Echinoid (nectins in mammals) ( Takahashi et al., 1999 ; Wei et al., 2005 ). Between the RA and PDZ domains are two other domains...

... of the primary Fibronectin receptors, is necessary for this inter-tissue adhesion and Fibronectin matrix assembly during neural tube morphogenesis ( Dray et al., 2013 ). Active Integrin α5β1 heterodimers are mainly present on the surface of the PSM where cells have little Cadherin 2. In contrast, Cadherin 2...

... Vestweber ABSTRACT Cadherin-mediated cell adhesion requires anchoring via the β-catenin–α-catenin complex to the actin cytoskeleton, yet, α-catenin only binds F-actin weakly. A covalent fusion of VE-cadherin to α-catenin enhances actin anchorage in endothelial cells and strongly stabilizes endothelial...

...Shigetaka Nishiguchi; Hiroki Oda ABSTRACT Type III cadherin represents the ancestral form of classical cadherin in bilaterian metazoans. Drosophila possesses type III and type IVa cadherins, known as DN- and DE-cadherins, respectively. Mature DN- and DE-cadherins have 15 and 7 extracellular...

... of a Wnt co-receptor, low-density lipoprotein receptor-related protein 6 (LRP6), and cell adhesion molecules of the cadherin family, thereby affecting steady-state levels of β-catenin. We conclude that clathrin impacts on Wnt/β-catenin signaling by controlling exocytosis of transmembrane proteins...

... way that cells associate with each other is through Ca 2+ -dependent adhesion molecules called cadherins, which mediate cell–cell interactions through adherens junctions, thereby anchoring and organizing the cortical actin cytoskeleton. This actin-based network confers dynamic properties to cell...

...Poonam Sehgal; Xinyu Kong; Jun Wu; Raimon Sunyer; Xavier Trepat; Deborah Leckband ABSTRACT This study reports novel findings that link E-cadherin (also known as CDH1)-mediated force-transduction signaling to vinculin targeting to intercellular junctions via epidermal growth factor receptor (EGFR...

...–cell adhesion by affecting the function of focal adhesion and E-cadherin, respectively. Our results demonstrate that Gα12 is required for the development of kidney cysts induced by Pkd1 mutation in mouse ADPKD. * Present address: Guangzhou Medical University, Guangdong, China. ‡ Present...

...Shigetaka Nishiguchi; Akira Yagi; Nobuaki Sakai; Hiroki Oda ABSTRACT Homophilic binding of E-cadherins through their ectodomains is fundamental to epithelial cell–cell adhesion. Despite this, E-cadherin ectodomains have evolved differently in the vertebrate and insect lineages. Of the five rod-like...

... of proteins in the desmosome, a structure mediating strong cell–cell adhesion, is elucidated by dSTORM super-resolution fluorescence microscopy. Cell adhesion Keratinocyte Super-resolution Fluorescence Microscopy Cadherin dSTORM National Institutes of Health 10.13039/100000002...

...Huapeng H. Yu; Michael R. Dohn; Nicholas O. Markham; Robert J. Coffey; Albert B. Reynolds ABSTRACT In vertebrate epithelia, p120-catenin (hereafter referred to as p120; also known as CTNND1) mediates E-cadherin stability and suppression of RhoA. Genetic ablation of p120 in various epithelial...

... and extracellular matrix composition. Cadherins mechanically link neighboring cells and are likely to contribute to fibrotic disease propagation. Finally, transition to the active myofibroblast phenotype leads to maladaptive tissue remodeling and enhanced mechanotransductive signaling, forming a positive feedback...

... contacts, mediated in part by Cadherin‐6B (Cad6B), migrate extensively, and later form a variety of adult derivatives. Importantly, modulation of Cad6B is crucial for proper neural crest cell EMT. Although Cad6B possesses a long half‐life, it is rapidly lost from premigratory neural crest cell membranes...

...Regina B. Troyanovsky; Indrajyoti Indra; Chi-Shuo Chen; Soonjin Hong; Sergey M. Troyanovsky ABSTRACT The mechanism that coordinates activities of different adhesion receptors is poorly understood. We investigated this mechanism by focusing on the nectin-2 and E-cadherin adherens junction receptors...

... the research performed so far on the role of flotillins in cell–cell adhesion. Recent studies have demonstrated that flotillins directly regulate the formation of cadherin complexes. Indeed, flotillin microdomains are required for the dynamic association and stabilization of cadherins at cell–cell junctions...

...Adrienne K. Barry; Hamid Tabdili; Ismaeel Muhamed; Jun Wu; Nitesh Shashikanth; Guillermo A. Gomez; Alpha S. Yap; Cara J. Gottardi; Johan de Rooij; Ning Wang; Deborah E. Leckband ABSTRACT The findings presented here demonstrate the role of α-catenin in cadherin-based adhesion and mechanotransduction...

... distinct upstream modules to stimulate Hippo-YAP signaling: adherens junction or cadherin–catenin complexes, epithelial polarity and tight junction complexes, the FAT-Dachsous morphogen pathway, as well as cell shape, actomyosin or mechanotransduction. Soluble extracellular factors also regulate Hippo...

... cranial neural crest EMT. Tspan18 mRNA is expressed in premigratory cranial neural crest cells, but is absent from actively migrating neural crest cells. Tspan18 knockdown leads to a concomitant loss of cadherin-6B (Cad6B) protein, whereas Cad6B protein persists when Tspan18 expression is extended...

...Patrick D. Allaire; Mohamed Seyed Sadr; Mathilde Chaineau; Emad Seyed Sadr; Sarah Konefal; Maryam Fotouhi; Deborah Maret; Brigitte Ritter; Rolando F. Del Maestro; Peter S. McPherson Summary Cells inversely adjust the plasma membrane levels of integrins and cadherins during cell migration and cell...

... events that might occur within a key mechanosensitive system at cell–cell junctions; the cadherin–F-actin interface, at which α-catenin and vinculin form a central module. Mechanotransduction at cell–cell junctions emerges as an important signaling mechanism, and we present examples of its potential...