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Keywords: CaMKK2
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Journal Articles

Disruption of ER–mitochondria contact sites induces autophagy-dependent loss of P-bodies through the Ca 2+ -CaMKK2-AMPK pathway

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In collection:
Autophagy , Organelles
Nikhil More, Jomon Joseph
Journal: Journal of Cell Science
J Cell Sci (2025) 138 (5): JCS263652.
https://doi.org/10.1242/jcs.263652
Published: 12 March 2025
.... Additionally, we find that the disruption of ERMCSs leads to cytosolic Ca 2+ -induced activation of CaMKK2 and AMP-activated protein kinase (AMPK), ultimately resulting in an autophagy-dependent decrease in PB abundance. Collectively, our findings unveil a mechanism wherein disturbances in ERMCSs induce...
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Includes: Supplementary data