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Keywords: CaMKII
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Journal Articles
J Cell Sci (2022) 135 (2): jcs258796.
Published: 18 January 2022
.... Summary: CaM mutations associated with human cardiac arrhythmia syndromes result in CaM dysfunction, which appears to be a key driver of the disease, with different mutants acting via different mechanisms. CPVT CaMKII RyR2 Arrhythmia Calcium signalling Calmodulin British Heart...
Includes: Supplementary data
Journal Articles
J Cell Sci (2018) 131 (13): jcs216101.
Published: 9 July 2018
... hippocampus. Furthermore, our findings reveal that Wnt7b and Fz7 induce the phosphorylation of Ca 2+ /calmodulin-dependent protein kinase II (CaMKII) and JNK proteins, which are required for dendritic development. Here, we demonstrate that Wnt7b–Fz7 signals through two non-canonical Wnt pathways to modulate...
Includes: Supplementary data
Journal Articles
In collection:
Lipid biology
J Cell Sci (2009) 122 (24): 4547–4557.
Published: 15 December 2009
... mouse spermatozoa with a CaMKII inhibitor that directly blocks the catalytic region of the kinase, as well as a competitive displacement of CaMKIIα from PDZ domains 10-11, led to a significant increase in spontaneous acrosomal exocytosis. Since Ca 2+ -calmodulin releases CaMKIIα from the PDZ scaffolding...
Journal Articles
J Cell Sci (2008) 121 (22): 3717–3728.
Published: 15 November 2008
... to the growth cone. Our data suggest that these morphological changes are induced by a signalling cascade in which CaMKII and FAK activity activates PI3-kinase and modifies the activity of its downstream targets. Thus, in the absence or inactivation of P2X7 receptor, axons grow more rapidly and form more...
Includes: Supplementary data
Journal Articles
J Cell Sci (2005) 118 (15): 3327–3338.
Published: 1 August 2005
...Tohru Umemura; Paris Rapp; Christopher Rongo Calcium and calmodulin-dependent protein kinase II (CaMKII) plays a fundamental role in the synaptic plasticity events that underlie learning and memory. Regulation of CaMKII kinase activity occurs through an autoinhibitory mechanism in which...