... sprouting and tube formation. Depletion of α6 (ITGA6) integrins resulted in similar phenotypes. Gene expression analysis indicated that loss of either laminin-511 or α6 integrins inhibited the expression of CXCR4 , a gene previously associated with angiogenic endothelial cells. Pharmacological or RNAi...

... activates VLA-4-mediated motility has remained unknown. We now report that VEGFR2 causes PKA-mediated phosphorylation of VLA-4 on S988, an event known to stimulate tumor metastasis while suppressing cytotoxic immune cells. A key partner in this mechanism is the chemokine receptor CXCR4, a well-known...

... controls the distribution of Notch1 itself and cell fate determinants, α-adaptin and Numb. Furthermore, Notch and CXCR4 signalling cooperated to drive polarity during division. Thus, Notch signalling directly orchestrates ACD, and Notch1 is differentially inherited by sibling cells. This article has...

...Lushen Li; Shaneen S. Baxter; Ning Gu; Min Ji; Xi Zhan ABSTRACT Surface expression of chemokine receptor CXCR4 is downregulated by missing-in-metastasis protein (MIM; also known as MTSS1), a member of the inverse BAR (I-BAR)-domain protein family that recognizes and generates membranes...

... by primary mouse muscle cells, especially during times of extensive cell–cell fusion. Furthermore, muscle cells exhibited different migratory behavior throughout myogenesis in vitro. One receptor–ligand pair, CXCR4–SDF-1α (CXCL12), regulated migration of both proliferating and terminally differentiated...

... protein. Drebrin colocalizes with the chemokine receptor CXCR4 and F-actin at the peripheral supramolecular activation cluster in the immune synapse. Drebrin interacts with the cytoplasmic tail of CXCR4 and both proteins redistribute to the immune synapse with similar kinetics. Drebrin knockdown in T...

...Amanda P. Struckhoff; Jason R. Vitko; Manish K. Rana; Carter T. Davis; Kamau E. Foderingham; Chi-Hsin Liu; Lyndsay Vanhoy-Rhodes; Steven Elliot; Yun Zhu; Matt Burow; Rebecca A. Worthylake CXCR4 is a chemokine receptor often found aberrantly expressed on metastatic tumor cells. To investigate CXCR4...

...Veysel Ödemis; Karina Boosmann; Maja Theresa Dieterlen; Jürgen Engele Mice deficient in the SDF1-chemokine-receptor CXCR4, exhibit severe defects of secondary limb myogenesis. To further elucidate the role of SDF1 in muscle development, we have now analyzed putative effects of this chemokine...

... Oct3 and/or Oct4 expression and teratoma formation. Furthermore, quantitative single cell analysis by flow cytometry using CXCR4, VEGFR2 and PDGFR-α indicated that this protocol for definitive endoderm and mesoderm differentiation is superior to any other available protocol. Our findings also indicated...

... determined. Here we show that CD24 affects the function of the chemokine receptor CXCR4. Using isolated CD19-positive bone marrow B cells from CD24-knockout mice and CD24 –/– pre-B lymphocytic cell lines, we demonstrate that CD24 expression reduces SDF-1-mediated cell migration and signalling via CXCR4. We...

... ). * Author for correspondence (e-mail: [email protected] ) 6 6 2005 © The Company of Biologists Limited 2005 2005 Chemokine CXCR4 Danio rerio Cell migration EMT E-cadherin In many organisms, primordial germ cells (PGCs) are specified early in development and subsequently...

... for the actual motility of PGCs. * Author for correspondence (e-mail: [email protected] ) 15 6 2004 © The Company of Biologists Limited 2004 2004 Danio rerio PGC Chemotaxis Cell migration PH domain G protein PI3K SDF-1 CXCR4 Chemokine Chemotaxis is defined as the ability...

... in lipopolysaccharide (LPS)-cellular activation, such as CD14, heat shock protein(hsp) 70, 90, Chemokine receptor 4 (CXCR4), growth differentiation factor 5(GDF5) and Toll-like receptor 4 (TLR4), are present in microdomains following LPS stimulation. Lipid raft integrity is essential for LPS-cellular activation, since...

...Nathalie Signoret; Mette M. Rosenkilde; P. J. Klasse; Thue W. Schwartz; Michael H. Malim; James A. Hoxie; Mark Marsh ABSTRACT The chemokine receptors CCR5 and CXCR4 are major co-receptors/receptors for the CD4-dependent and CD4-independent entry of human and simian immunodeficiency viruses...