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Keywords: CRM1
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Journal Articles
J Cell Sci (2021) 134 (6): jcs258095.
Published: 26 March 2021
...Mohamed Hamed; Birgit Caspar; Sarah A. Port; Ralph H. Kehlenbach ABSTRACT Nup214 is a major nucleoporin on the cytoplasmic side of the nuclear pore complex with roles in late steps of nuclear protein and mRNA export. It interacts with the nuclear export receptor CRM1 (also known as XPO1) via...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (18): jcs241943.
Published: 23 September 2020
... class of Hox transcriptional cofactors that act in development and cancer. We show that this unconventional NES is involved in the interaction with the major exportin protein CRM1 (also known as Embargoed in flies) in vivo and in vitro . We find that this interaction is tightly regulated in the...
Includes: Supplementary data
Journal Articles
J Cell Sci (2019) 132 (7): jcs225698.
Published: 08 April 2019
... that HIF-2α associates with the exportin chromosomal maintenance 1 (CRM1, also known as XPO1) in a phosphorylation-sensitive manner and identify two critical leucine residues as part of an atypical CRM1-dependent nuclear export signal (NES) neighboring serine 672. Inhibition of CRM1 or mutation of...
Includes: Supplementary data
Journal Articles
J Cell Sci (2018) 131 (3): jcs204644.
Published: 01 February 2018
... JNK pathway inhibition. Moreover, activation of the JNK or p38 MAPK family pathway is sufficient to elicit Net1A cytosolic localization. Net1A relocalization stimulated by EGF or JNK activation requires nuclear export mediated by CRM1. JNK1 (also known as MAPK8) phosphorylates Net1A on serine 52, and...
Includes: Supplementary data
Journal Articles
J Cell Sci (2017) 130 (13): 2185–2195.
Published: 01 July 2017
...-particle tracking and super-resolution microscopy. We provide evidence for a regulatory role of CRM1 (chromosome-region-maintenance-1; also known as XPO1, exportin-1) in juxta-nuclear microtubule-dependent adenovirus transport. Leptomycin B (LMB) abolishes nuclear targeting of adenovirus. It binds to CRM1...
Includes: Supplementary data
Journal Articles
J Cell Sci (2016) 129 (22): 4213–4226.
Published: 15 November 2016
... Company of Biologists Ltd 2016 http://www.biologists.com/user-licence-1-1/ Summary: Phosphorylation of hypoxia inducible factor 2α mediated by casein kinase 1δ increases erythropoietin production by impairing a CRM1-dependent nuclear export mechanism in liver cancer cells. HIF-2 CK1...
Includes: Supplementary data
Journal Articles
J Cell Sci (2013) 126 (15): 3417–3428.
Published: 01 August 2013
..., the nuclear transport factors that facilitate protein import into the nucleus during interphase. In addition, the nuclear export factor Crm1 has been proposed to act as a mitotic effector of RanGTP through the localized assembly of protein complexes on the mitotic spindle, notably at centrosomes and...
Includes: Supplementary data
Journal Articles
J Cell Sci (2012) 125 (21): 5168–5176.
Published: 01 November 2012
...-hydroxylase HIF NLS NES Importin CRM1 Due to an imbalance in oxygen supply and demand, solid tumours commonly evolve hypoxic regions associating with malignant cancer phenotype and poor patient survival. As a result, hypoxia stimulated pathways, including the hypoxia-inducible factor (HIF...
Journal Articles
J Cell Sci (2012) 125 (1): 144–154.
Published: 01 January 2012
...Inga Waldmann; Christiane Spillner; Ralph H. Kehlenbach Translocation of transport complexes across the nuclear envelope is mediated by nucleoporins, proteins of the nuclear pore complex that contain phenylalanine-glycine (FG) repeats as a characteristic binding motif for transport receptors. CRM1...
Includes: Supplementary data
Journal Articles
J Cell Sci (2009) 122 (20): 3772–3779.
Published: 15 October 2009
...Peng Wang; Guang-Hui Liu; Kaiyuan Wu; Jing Qu; Bo Huang; Xu Zhang; XiXi Zhou; Larry Gerace; Chang Chen The karyopherin chromosomal region maintenance 1 (CRM1) is the major receptor for classical nuclear protein export. However, little is known about the regulation of CRM1 itself. Here, we report...
Includes: Supplementary data
Journal Articles
J Cell Sci (2007) 120 (9): 1540–1550.
Published: 01 May 2007
... live-cell microscopy techniques can detect subtle quantitative disturbances in nuclear dynamics before they have had an effect on overall nuclear organization. Inhibition of the nuclear export factor, CRM1, using leptomycin B results in a change in the dynamics of interaction of newly imported snRNPs...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2004) 117 (11): 2259–2270.
Published: 01 May 2004
...Tominori Kimura; Iwao Hashimoto; Takahiro Nagase; Jun-Ichi Fujisawa While the bulk of cellular mRNA is known to be exported by the TAP pathway, export of specific subsets of cellular mRNAs may rely on chromosome region maintenance 1 (CRM1). One line of evidence supporting this hypothesis comes from...
Journal Articles
J Cell Sci (2003) 116 (12): 2409–2419.
Published: 15 June 2003
.... We analyzed the role of CRM1, the export receptor for leucine-rich nuclear export signals (NES), in the biogenesis of ribosomal subunits in vertebrate cells. Inhibition of the CRM1 export pathway led to a defect in nuclear export of both 40S and 60S subunits in HeLa cells. Moreover, the export of...
Includes: Supplementary data