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Keywords: CLASP2
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Journal Articles
In collection:
Cytoskeleton
J Cell Sci (2017) 130 (8): 1404–1412.
Published: 15 April 2017
... understood. In addition to the NDC80 microtubule-binding complex, other proteins with demonstrated microtubule-binding activities localize to kinetochores. One such protein is the cytoplasmic linker-associated protein 2 (CLASP2). Here, we show that global GSK3-mediated phosphorylation of the longest isoform...
Journal Articles
J Cell Sci (2017) 130 (4): 683–688.
Published: 15 February 2017
... Clasp2 is intimately associated with the basal proliferative makeup of keratinocytes, and its deficiency leads to premature differentiation. Clasp2-deficient keratinocytes exhibit increased centrosomal numbers and numerous mitotic alterations, including multipolar spindles and chromosomal misalignments...
Includes: Supplementary data
Journal Articles
Journal Articles
J Cell Sci (2010) 123 (19): 3215–3225.
Published: 1 October 2010
... peripheral protein p230 and that this localization regulated CLASP2 phosphorylation. Our results also show that GSK3β knockdown resulted in accumulation of CLASP2 at microtubule plus ends at the cell periphery. Our findings support the hypothesis that GSK3β at the TGN acts as a guide, activates exocytic...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2009) 122 (16): 2969–2979.
Published: 15 August 2009
... for this asymmetric distribution of CLASPs. However, it is not known how GSK-3β regulates the activity of CLASPs for linkage between actin and microtubules. Here we identified IQGAP1, an actin-binding protein, as a novel CLASP-binding protein. GSK-3β directly phosphorylates CLASP2 at Ser533 and Ser537 within...
Includes: Supplementary data