... the glucose transporter GLUT1 (also known as SLC2A1). The role of retromer in the retrograde sorting of the cation-independent mannose 6-phosphate receptor (CI-MPR, also known as IGF2R) from endosomes back to the trans -Golgi network remains controversial. Here, by applying knocksideways technology, we...

... Endosome CI-MPR TGN Sorting nexin Retromer In mammalian cells, there are two distinct mannose-6-phosphate receptors (MPRs) - the cation-dependent and cation-independent MPRs (CD-MPR and CI-MPR, respectively) ( Ghosh et al., 2003 ). These receptors function by associating with the mannose-6...

... Limited 2005 2005 Sorting nexin Retromer CI-MPR Phosphoinositide PX-domain The endosomal system functions as an internal membraneous network designed to sort internalised cargo to appropriate subcellular destinations. Molecules internalised at the cell surface are initially delivered...