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Keywords: CI-MPR
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Journal Articles
Acute inactivation of retromer and ESCPE-1 leads to time-resolved defects in endosomal cargo sorting
Open Access
Journal:
Journal of Cell Science
J Cell Sci (2020) 133 (15): jcs246033.
Published: 3 August 2020
... the glucose transporter GLUT1 (also known as SLC2A1). The role of retromer in the retrograde sorting of the cation-independent mannose 6-phosphate receptor (CI-MPR, also known as IGF2R) from endosomes back to the trans -Golgi network remains controversial. Here, by applying knocksideways technology, we...
Includes: Supplementary data
Journal Articles
A loss-of-function screen reveals SNX5 and SNX6 as potential components of the mammalian retromer
Available to Purchase
Journal:
Journal of Cell Science
J Cell Sci (2007) 120 (1): 45–54.
Published: 1 January 2007
...× objective under epifluorescence illumination. Images were analysed by visual inspection and cells arbitrarily divided into two classes: one with compact steady-state localization of the CI-MPR in the TGN, the other one with fragmentation/vesiculation of the Golgi and/or dispersed MPR staining throughout...
Includes: Multimedia, Supplementary data
Journal Articles
Sorting nexin-2 is associated with tubular elements of the early endosome, but is not essential for retromer-mediated endosome-to-TGN transport
Available to PurchaseJez G. Carlton, Miriam V. Bujny, Brian J. Peter, Viola M. J. Oorschot, Anna Rutherford, Rebecca S. Arkell, Judith Klumperman, Harvey T. McMahon, Peter J. Cullen
Journal:
Journal of Cell Science
J Cell Sci (2005) 118 (19): 4527–4539.
Published: 1 October 2005
... Limited 2005 2005 Sorting nexin Retromer CI-MPR Phosphoinositide PX-domain The endosomal system functions as an internal membraneous network designed to sort internalised cargo to appropriate subcellular destinations. Molecules internalised at the cell surface are initially delivered...