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Keywords: CDK
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Journal Articles
J Cell Sci (2019) 132 (6): jcs226969.
Published: 25 March 2019
... is a common feature of cancer cells, and thus a potentially important therapeutic target. Here, we show that cyclin-dependent kinase (CDK)-induced replication stress, resulting from Wee1 inactivation, is synthetic lethal with mutations disrupting dNTP homeostasis in fission yeast. Wee1 inactivation leads...
Includes: Supplementary data
Journal Articles
J Cell Sci (2016) 129 (13): 2559–2572.
Published: 01 July 2016
... report that Cdk-dependent TRF1 phosphorylation on T371 acts as a switch to create a pool of TRF1, referred to as (pT371)TRF1, which is recruited to ALT-associated PML bodies (APBs) in S and G2 phases independently of its binding to telomeric DNA. We find that phosphorylation of T371 is essential for APB...
Includes: Supplementary data
Journal Articles
J Cell Sci (2014) 127 (11): 2391–2400.
Published: 01 June 2014
....   ( 2011 ). Cdk5 is required for memory function and hippocampal plasticity via the cAMP signaling pathway.   PLoS ONE   6 , e25735 . 10.1371/journal.pone.0025735 Guidato   S. , McLoughlin   D. M. , Grierson   A. J. , Miller   C. C. ( 1998 ). Cyclin D2 interacts with cdk-5...
Journal Articles
J Cell Sci (2008) 121 (13): 2208–2216.
Published: 01 July 2008
... that is characterized by delayed chromosome decondensation and aberrant rearrangement of the meiotic spindle. The smg7 phenotype was mimicked by exposing meiocytes to the proteasome inhibitor MG115. Together, these data indicate that SMG7 counteracts cyclin-dependent kinase (CDK) activity at the end of meiosis...
Includes: Supplementary data
Journal Articles
J Cell Sci (2002) 115 (12): 2461–2464.
Published: 15 June 2002
... Cdk1,the first cyclin-dependent protein kinase. (e-mail: doree@crbm.cnrs-mop.fr ; tim.hunt@cancer.org.uk ) © The Company of Biologists Limited 2002 2002 Cell cycle CDK Cyclin MPF Oocyte Protein kinase The two major processes common to all cell cycles are S phase, when...
Journal Articles
J Cell Sci (2002) 115 (11): 2265–2270.
Published: 01 June 2002
... during mitosis, and its inactivation releases this silencing. The formation of PNBs is also controlled by the CDK1 pathway, whereas the recruitment of the rRNA-processing machinery appears to depend on the activity of another CDK ( Fig. 2 ). The characterization of the CDK(s) controlling this process...
Journal Articles
J Cell Sci (2001) 114 (24): 4599–4611.
Published: 15 December 2001
... , 801 -813. Lanker, S., Valdivieso, M. H. and Wittenberg, C. ( 1996 ). Rapid degradation of the G1 cyclin Cln2 induced by CDK-dependent phosphorylation. Science 271 , 1597 -1601. Lee, J., Colwill, K., Aneliunas, V., Tennyson, C., Moore, L., Ho, Y. and Andrews, B. ( 1998 ). Interaction...
Journal Articles
J Cell Sci (1994) 1994 (Supplement_18): 69–73.
Published: 01 January 1994
...Steven I. Reed; Eric Bailly; Vjekoslav Dulic; Ludger Hengst; Dalia Resnitzky; Joyce Slingerland SUMMARY Cyclin-dependent kinases (Cdks) control the major cell cycle transitions in eukaryotic cells. On the basis of a variety of experiments where cyclin function either is impaired or enhanced, D-type...
Journal Articles
J Cell Sci (1994) 1994 (Supplement_18): 75–79.
Published: 01 January 1994
..., incomplete DNA replication or spindle assembly. In many organisms, transition points seem to involve regulation of the activity of cyclin-dependent kinases (cdks) not only through their interactions with various cyclins, but also by phosphorylation-dephosphorylation cycles acting on the kinase activity...
Journal Articles
J Cell Sci (1992) 1992 (Supplement_16): 77–85.
Published: 01 January 1992
... for coupling cell-cycle events to transcriptional initiation. * Corresponding author © The Company of Biologists Limited 1992 1992 cyclin transcription retinoblastoma CDK tumour suppressor Journal of Cell Science, Supplem ent 16, 77-85 (1992) Printed in Great Britain © The Company o f...