...Natsumi Noda; Takeaki Ozawa ABSTRACT Cluster of differentiation 44 (CD44) is a single-pass transmembrane glycoprotein that is a widely distributed cell-surface adhesion molecule. CD44 undergoes ectodomain cleavage by membrane-associated metalloproteinases in breast cancer cells. Cleavage plays...

.... We find that podoplanin and its partner proteins CD44 and CD9 are differentially expressed by specific lymph node stromal populations in vivo , and their expression in FRCs is coregulated by CLEC-2 (encoded by CLEC1B ). Both CD44 and CD9 suppress podoplanin-dependent contractility. We find...

... is a crucial aspect of neuronal development towards the formation of a functional network. The role of the extracellular matrix and its cellular receptors in this process has remained enigmatic. We report that the CD44 adhesion molecule, the main hyaluronan receptor, is localized in dendrites and plays...

...Phrabha S. Raman; Christina S. Alves; Denis Wirtz; Konstantinos Konstantopoulos P-selectin and fibrin(ogen) have pivotal roles in the hematogenous dissemination of tumor cells. CD44 variant isoforms, CD44v, have been identified as the major functional P-selectin ligands and fibrin receptors...

...Pinak S. Acharya; Sonali Majumdar; Michele Jacob; James Hayden; Paul Mrass; Wolfgang Weninger; Richard K. Assoian; Ellen Puré CD44 contributes to inflammation and fibrosis in response to injury. As fibroblast recruitment is critical to wound healing, we compared cytoskeletal architecture...

... that might contribute to tumor progression by promoting genomic instability. Extracellular RHAMM-CD44 partnering sustains CD44 surface display and enhances CD44-mediated signaling through ERK1 and ERK2 (ERK1/2); it might also contribute to tumor progression by enhancing and/or activating the latent tumor...

... to downregulate CD44 expression. These data indicate that CD44 is the principal receptor mediating this response and that CD44 expression is not a general requirement for cell migration and gradient sensing, rather it elicits a ligand-specific response. However, expression of CD44 alone is not sufficient to drive...

...Rick F. Thorne; James W. Legg; Clare M. Isacke CD44 is a widely distributed type I transmembrane glycoprotein and functions as the major hyaluronan receptor on most cell types. Although alternative splicing can produce a large number of different isoforms, they all retain the hyaluronan-binding...

... and MMP-13 expression is receptor mediated, they rule out an involvement of the hyaluronan receptors CD44, RHAMM/IHAP and TLR-4. Finally, we show that HA fragment-induced MMP-9 transcription is mediated via NF-κB. Our results suggest that the metastasis-associated HA degradation in tumours might promote...

... The Company of Biologists Limited 2002 2002 Hyaluronan Hyaluronan synthase 2 Keratinocyte Migration Adhesion plaques Vinculin CD44 Hyaluronan is a ubiquitous, high molecular weight glycosaminoglycan involved in various aspects of mammalian tissue physiology, including matrix space filling...

... of those genes necessary for implementation of the invasion programme. Two such gene products, CD44 and ezrin, are both upregulated in fibroblasts transformed by v- fos and are commonly implicated in cell motility and invasion. Here we report that CD44 and ezrin colocalise to membrane ruffles...

...Shulamit B. Wallach-Dayan; Valentin Grabovsky; Jürgen Moll; Jonathan Sleeman; Peter Herrlich; Ronen Alon; David Naor Cell motility is an essential element of tumor dissemination, allowing organ infiltration by cancer cells. Using mouse LB lymphoma cells transfected with standard CD44 (CD44s) cDNA...

... -bn upon the intracellular trafficking of basolateral and apical membrane glycoproteins at the cellular and biochemical levels in two types of cells, HT-29 G − and Caco-2, differentiated into an enterocyte-like phenotype. In HT-29 G − cells, but not in Caco-2 cells, DPP-IV and CD44 failed...

..., and that after puberty CD44v6 epitope expression follows the estrous cycle. CD44v6 epitope expression is observed in the myoepithelium and also less widely in luminal epithelial cells. During lactation, CD44v6 epitope expression is turned off and reappears during involution. The CD44 variant isoform bearing...

...David Peck; Clare M. Isacke ABSTRACT CD44 is the principle transmembrane receptor for the extracellular matrix glycosaminoglycan hyaluronan. This receptor:ligand interaction plays an essential role in a number of physiological events including tumour progression, lymphocyte homing into inflammatory...

...Lesley E. Esford; Arpita Maiti; Sharon A. Bader; Frank Tufaro; Pauline Johnson ABSTRACT CD44 is a widely expressed cell adhesion molecule that binds the extracellular matrix component, hyaluronan, in a tightly regulated manner. Previous studies have shown that the CD44-hyaluronan interaction...

... and sporadic schwannomas and meningiomas. The protein shares the domain structure of three homologous proteins: ezrin, radixin and moesin (ERM). ERM proteins function as membrane organizers and may act as linkers between plasma membrane molecules, such as CD44 and ICAM-2, and the cytoskeleton. We analyzed...

...Matthias Goebeler; Dieter Kaufmann; Eva-Bettina Bröcker; C. Eberhard Klein ABSTRACT Recent evidence indicates that CD44, a multifunctional adhesion receptor involved in cell-cell as well as in cell-matrix interactions, plays an important role in local progression and metastasis of malignant tumors...

...Stephen J. Neame; Caroline R. Uff; Humma Sheikh; Susan C. Wheatley; Clare M. Isacke ABSTRACT CD44 is an abundant, widely expressed transmembrane glycoprotein which can act as a receptor for the extracellular matrix glycosaminoglycan, hyaluronan. Biochemical and morphological studies have...

...Armando Bartolazzi; David Jackson; Kelly Bennett; Alejandro Aruffo; Richard Dickinson; John Shields; Nigel Whittle; Ivan Stamenkovic ABSTRACT CD44 is a polymorphic cell surface glycoprotein, currently proposed to be the principal cell surface receptor for hyaluronan. However, different isoforms...