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Keywords: CD44
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Journal Articles
J Cell Sci (2014) 127 (23): 5038–5051.
Published: 01 December 2014
... crucial aspect of neuronal development towards the formation of a functional network. The role of the extracellular matrix and its cellular receptors in this process has remained enigmatic. We report that the CD44 adhesion molecule, the main hyaluronan receptor, is localized in dendrites and plays a...
Includes: Supplementary data
Journal Articles
J Cell Sci (2011) 124 (11): 1903–1910.
Published: 01 June 2011
...Phrabha S. Raman; Christina S. Alves; Denis Wirtz; Konstantinos Konstantopoulos P-selectin and fibrin(ogen) have pivotal roles in the hematogenous dissemination of tumor cells. CD44 variant isoforms, CD44v, have been identified as the major functional P-selectin ligands and fibrin receptors on...
Includes: Supplementary data
Journal Articles
J Cell Sci (2008) 121 (9): 1393–1402.
Published: 01 May 2008
...Pinak S. Acharya; Sonali Majumdar; Michele Jacob; James Hayden; Paul Mrass; Wolfgang Weninger; Richard K. Assoian; Ellen Puré CD44 contributes to inflammation and fibrosis in response to injury. As fibroblast recruitment is critical to wound healing, we compared cytoskeletal architecture and...
Journal Articles
J Cell Sci (2008) 121 (7): 925–932.
Published: 01 April 2008
... might contribute to tumor progression by promoting genomic instability. Extracellular RHAMM-CD44 partnering sustains CD44 surface display and enhances CD44-mediated signaling through ERK1 and ERK2 (ERK1/2); it might also contribute to tumor progression by enhancing and/or activating the latent tumor...
Journal Articles
J Cell Sci (2005) 118 (21): 5119–5128.
Published: 01 November 2005
... downregulate CD44 expression. These data indicate that CD44 is the principal receptor mediating this response and that CD44 expression is not a general requirement for cell migration and gradient sensing, rather it elicits a ligand-specific response. However, expression of CD44 alone is not sufficient to drive...
Journal Articles
J Cell Sci (2004) 117 (3): 373–380.
Published: 22 January 2004
...Rick F. Thorne; James W. Legg; Clare M. Isacke CD44 is a widely distributed type I transmembrane glycoprotein and functions as the major hyaluronan receptor on most cell types. Although alternative splicing can produce a large number of different isoforms, they all retain the hyaluronan-binding...
Journal Articles
J Cell Sci (2004) 117 (2): 359–367.
Published: 15 January 2004
... MMP-13 expression is receptor mediated, they rule out an involvement of the hyaluronan receptors CD44, RHAMM/IHAP and TLR-4. Finally, we show that HA fragment-induced MMP-9 transcription is mediated via NF-κB. Our results suggest that the metastasis-associated HA degradation in tumours might promote...
Journal Articles
J Cell Sci (2002) 115 (18): 3633–3643.
Published: 15 September 2002
... 2002 © The Company of Biologists Limited 2002 2002 Hyaluronan Hyaluronan synthase 2 Keratinocyte Migration Adhesion plaques Vinculin CD44 Hyaluronan is a ubiquitous, high molecular weight glycosaminoglycan involved in various aspects of mammalian tissue physiology, including...
Journal Articles
J Cell Sci (2002) 115 (13): 2713–2724.
Published: 01 July 2002
... of those genes necessary for implementation of the invasion programme. Two such gene products, CD44 and ezrin, are both upregulated in fibroblasts transformed by v- fos and are commonly implicated in cell motility and invasion. Here we report that CD44 and ezrin colocalise to membrane ruffles and...
Journal Articles
J Cell Sci (2001) 114 (19): 3463–3477.
Published: 01 October 2001
...Shulamit B. Wallach-Dayan; Valentin Grabovsky; Jürgen Moll; Jonathan Sleeman; Peter Herrlich; Ronen Alon; David Naor Cell motility is an essential element of tumor dissemination, allowing organ infiltration by cancer cells. Using mouse LB lymphoma cells transfected with standard CD44 (CD44s) cDNA...
Journal Articles
J Cell Sci (1994) 107 (9): 2353–2359.
Published: 01 September 1994
...Clare M. Isacke © 1992 by Company of Biologists 1992 CD44 hyaluronan receptor cytoskeleton REFERENCES Aruffo A. , Stamenkovic I. , Melnick M. , Underhill C. B. , Seed B. ( 1990 ). CD44 is the principal cell surface receptor for hyaluronate. Cell...
Journal Articles
J Cell Sci (1992) 103 (2): 293–298.
Published: 01 October 1992
...CHARLES UNDERHILL © 1992 by Company of Biologists 1992 CD44 hyaluron receptor hyaladherins. REFERENCES Alho A. M. , Underhill C. B. ( 1989 ). The hyaluronate receptor is preferentially expressed on proliferating epithelial cells. J. Cell Biol 108 , 1557 – 1565...