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Keywords: C2 domain
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Journal Articles
J Cell Sci (2018) 131 (19): jcs207951.
Published: 11 October 2018
... by transiently translocating to the plasma membrane, and that calcium is a direct regulator of AdcC localization. This response requires the calcium-dependent membrane-targeting C2 domain and the double SAM domain involved in AdcC oligomerization, revealing a mode of membrane targeting and regulation unique...
Includes: Supplementary data
Journal Articles
J Cell Sci (2006) 119 (12): 2552–2562.
Published: 15 June 2006
... cause the same defect in membrane fusion. FER-1 and the ferlin protein family are membrane proteins with four to seven C2 domains. These domains commonly mediate Ca 2+ -dependent lipid-processing events. Most of the fer-1 mutations fall within these C2 domains, showing that they have distinct, non...
Includes: Supplementary data
Journal Articles
J Cell Sci (2004) 117 (19): 4365–4375.
Published: 01 September 2004
... phospholipid-binding domain near their N-termini. Although they are still membrane associated, truncation mutants of the class I Rab11-FIPs that lack their C2 domains display an altered subcellular distribution in vivo, indicating that this domain plays an important role in specifying their correct...
Journal Articles
J Cell Sci (2002) 115 (9): 1847–1857.
Published: 01 May 2002
... characterize Pub2p, which contains a conserved HECT domain and a WW domain but lacks a C2 domain. Transcription of the pub2 + gene was constitutive and further enhanced by nitrogen starvation. A pub2 -null mutation gave no remarkable phenotypes, but intensified temperature sensitivity in a pub1Δ background...