... function by sorting cargo to distinct endosomal membrane domains that subsequently undergo budding and fission and give rise to an array of tubulo-vesicular structures that transport cargo along microtubules to the perinuclear ERC (Grant and Donaldson, 2009 ; Jovic et al., 2010), which in itself...

...Anna Marchetti; Valentina Mercanti; Sophie Cornillon; Laeticia Alibaud; Steve J. Charette; Pierre Cosson Multivesicular endosomes are present in virtually every eucaryotic cell, where they arise by intra-endosomal budding of the limiting endosomal membrane. Some genetic diseases such as Chediak...

... cellular proteins from the mutivesicular body (MVB) pathway during the budding process. The Gag proteins of oncoretroviruses possess a PPxY motif that recruits a ubiquitin ligase from the Nedd4 family, whereas those of the human immunodeficiency virus interact through a PTAP motif with Tsg101, a protein...