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Keywords: Breast cancer
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Journal Articles
J Cell Sci (2022) 135 (17): jcs258396.
Published: 30 August 2022
... receptor 3 (TGFBR3) acts as an anoikis mediator through the coordination of activating transcription factor 4 (ATF4). In breast cancer tissues, TGFBR3 is progressively lost, but elevated TGFBR3 is associated with a histologic subtype characterized by cellular adhesion defects. Dissecting the impact...
Includes: Supplementary data
Journal Articles
J Cell Sci (2022) 135 (10): jcs259329.
Published: 20 May 2022
... Comma-1D cells can be used as an experimental model to study both the differentiation and the transformation processes in vitro . Comma-1D Mammary epithelium differentiation Stem cells Oncogenesis Breast cancer National Institutes of Health http://dx.doi.org/10.13039/100000002...
Includes: Supplementary data
Journal Articles
Series: REVIEW COMMONS TRANSFER
J Cell Sci (2022) 135 (7): jcs259456.
Published: 11 April 2022
.... To determine the underlying molecular mechanisms, we mapped the genome-wide localization of endogenous macroH2A1.1 in the human breast cancer cell line MDA-MB-231. We demonstrate that macroH2A1.1 specifically binds to active promoters and enhancers in addition to facultative heterochromatin. Selective knock...
Includes: Supplementary data
Journal Articles
J Cell Sci (2022) 135 (7): jcs258809.
Published: 1 April 2022
... is typically reliant on bleb formation. Here we demonstrate that thrombin induces dynamic blebbing in the MDA-MB-231 breast cancer cell line and confirm that protease-activated receptor 1 (PAR1) activation is sufficient to induce this effect. Cell confinement has been implicated as a driving force in bleb...
Includes: Supplementary data
Journal Articles
J Cell Sci (2022) 135 (6): jcs259314.
Published: 17 March 2022
...Natsumi Noda; Takeaki Ozawa ABSTRACT Cluster of differentiation 44 (CD44) is a single-pass transmembrane glycoprotein that is a widely distributed cell-surface adhesion molecule. CD44 undergoes ectodomain cleavage by membrane-associated metalloproteinases in breast cancer cells. Cleavage plays...
Includes: Supplementary data
Journal Articles
J Cell Sci (2021) 134 (21): jcs258418.
Published: 5 November 2021
...Meera Saxena; Mizue Hisano; Melanie Neutzner; Maren Diepenbruck; Robert Ivanek; Kirti Sharma; Ravi K. R. Kalathur; Thomas R. Bürglin; Salvatore Risoli; Gerhard Christofori ABSTRACT The vast majority of breast cancer-associated deaths are due to metastatic spread of cancer cells, a process aided...
Includes: Supplementary data
Journal Articles
J Cell Sci (2021) 134 (15): jcs240135.
Published: 10 August 2021
... depletion in tumour cells caused redistribution of the actin cytoskeleton and increased activity of the Rho GTPase CDC42, known for its role in actin remodelling and cell migration. In a xenograft model of breast cancer, tumour cell CD99 expression inhibited metastatic progression, and patient samples...
Includes: Supplementary data
Journal Articles
J Cell Sci (2021) 134 (11): jcs256503.
Published: 7 June 2021
...Hyungjoo Kim; Seogho Son; Yunhyo Ko; Jeong Eon Lee; Sangmin Kim; Incheol Shin ABSTRACT About 70% of breast cancers overexpress estrogen receptor α (ERα, encoded by ESR1 ). Tamoxifen, a competitive inhibitor of estrogen that binds to ER, has been widely used as a treatment for ER-positive breast...
Includes: Supplementary data
Journal Articles
J Cell Sci (2021) 134 (7): jcs252304.
Published: 15 April 2021
...(A) polymerase, poly(A) polymerase α (PAPOLA), in cancer, we assessed its expression in 221 breast cancer samples and found it to correlate strongly with the aggressive triple-negative subtype. Silencing PAPOLA in MCF-7 and MDA-MB-231 breast cancer cells reduced proliferation and anchorage-independent growth...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (9): jcs236125.
Published: 11 May 2020
...Ang Lu; Wei Wang; Shu-Fang Wang-Renault; Brian Z. Ring; Yoshimasa Tanaka; Jun Weng; Li Su ABSTRACT Human breast cancer cells exhibit considerable diversity in the methylation status of genomic DNA CpGs that regulate metastatic transcriptome networks. In this study, we identified human Sipa1...
Includes: Supplementary data
Journal Articles
In collection:
Stem Cells
J Cell Sci (2020) 133 (2): jcs232470.
Published: 23 January 2020
... – that not only affects the behavior of cells but also disrupts their ability to restore tissue integrity. While abnormal tissue properties, including increased extracellular matrix stiffness, are linked with the risk of developing breast cancer, the role and contribution of senescent MSCs to the disease...
Includes: Supplementary data
Journal Articles
J Cell Sci (2019) 132 (20): jcs232058.
Published: 23 October 2019
...Maitreyi Rathod; Sushmita Chatterjee; Shruti Dutta; Rajiv Kalraiya; Dibyendu Bhattacharyya; Abhijit De ABSTRACT Chasing an intriguing biological question on the disparity of sodium iodide symporter (NIS, officially known as SLC5A5) expression and function in the clinical scenario of breast cancer...
Includes: Supplementary data
Journal Articles
In collection:
Autophagy
J Cell Sci (2019) 132 (20): jcs234120.
Published: 22 October 2019
... cell death via TRIB3 upregulation; and (ii) inhibition of invasiveness via abrogation of RAC1 SUMOylation. SUMO modification Rho-GTPase Breast cancer Autophagy Ginkgolic acid TRIB3 The post-translational addition of the small ubiquitin-related modifier (SUMO) peptide is now...
Includes: Supplementary data
Journal Articles
J Cell Sci (2019) 132 (11): jcs223172.
Published: 5 June 2019
... in MDA-MB-231 breast cancer cells in which early endosomes demonstrated aberrantly enriched F-actin and accumulated the metalloproteinase MT1-MMP (also known as MMP14) upon DLC3 knockdown. Remarkably, Rab4 (herein referring to Rab4A) downregulation fully rescued the enhanced matrix degradation of TGF-β...
Includes: Supplementary data
Journal Articles
J Cell Sci (2018) 131 (21): jcs220640.
Published: 29 October 2018
... with poor prognosis. Here, we report that CD151 is involved in regulation of the expression of fibroblast growth factor receptor 2 (FGFR2). Depletion of CD151 in breast cancer cells resulted in an increased level of FGFR2. Accordingly, an inverse correlation between CD151 and FGFR2 was observed in breast...
Includes: Supplementary data
Journal Articles
J Cell Sci (2018) 131 (16): jcs212563.
Published: 23 August 2018
...Clara R. L. Oudenaarden; Robert A. H. van de Ven; Patrick W. B. Derksen ABSTRACT Metastatic breast cancer is responsible for most breast cancer-related deaths. Disseminated cancer cells have developed an intrinsic ability to resist anchorage-dependent apoptosis (anoikis). Anoikis is caused...
Journal Articles
J Cell Sci (2017) 130 (19): 3399–3413.
Published: 1 October 2017
... for CCL2, is implicated in cancer progression. However, we found that a higher CCR2 mRNA level is remarkably associated with prolonged survival of breast cancer patients. These conflicting results prompted us to study the non-coding function of CCR2 mRNA. We found that the CCR2 3′ untranslated region (UTR...
Includes: Supplementary data
Journal Articles
J Cell Sci (2017) 130 (14): 2292–2305.
Published: 15 July 2017
... and cell survival. Our studies identify the transient receptor potential canonical-1 (TRPC1) ion channel as a key component of responses to hypoxia in breast cancer cells. This regulation includes control of specific epithelial to mesenchymal transition (EMT) events and hypoxia-mediated activation...
Includes: Supplementary data
Journal Articles
In collection:
Adhesion
J Cell Sci (2017) 130 (13): 2172–2184.
Published: 1 July 2017
... identified the focal adhesion protein tensin3 (Tns3) as a determinant of adhesion plasticity. Tns3 is strongly reduced at mRNA and protein levels in suspension cells. Furthermore, by transiently challenging breast cancer cells to grow under non-adherent conditions markedly reduces Tns3 protein expression...
Includes: Supplementary data
Journal Articles
J Cell Sci (2017) 130 (4): 697–711.
Published: 15 February 2017
... cargoes, which we have used to determine that Rab17 controls Vamp8 levels to drive neuropilin-2 trafficking, promoting invasion. SILAC Rab17 Vamp8 Neuropilin-2 Ductal carcinoma in situ Invasive ductal carcinoma Late endosome Cell migration Invasion Breast cancer The membrane...
Includes: Supplementary data