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Keywords: Breast cancer
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Journal Articles
J Cell Sci jcs.258418.
Published: 11 October 2021
...Meera Saxena; Mizue Hisano; Melanie Neutzner; Maren Diepenbruck; Robert Ivanek; Kirti Sharma; Ravi K.R. Kalathur; Thomas R. Bürglin; Salvatore Risoli; Gerhard Christofori The vast majority of breast cancer-associated deaths are due to metastatic spread of cancer cells, a process aided by epithelial...
Journal Articles
J Cell Sci (2021) 134 (15): jcs240135.
Published: 10 August 2021
... depletion in tumour cells caused redistribution of the actin cytoskeleton and increased activity of the Rho GTPase CDC42, known for its role in actin remodelling and cell migration. In a xenograft model of breast cancer, tumour cell CD99 expression inhibited metastatic progression, and patient samples...
Includes: Supplementary data
Journal Articles
J Cell Sci (2021) 134 (11): jcs256503.
Published: 07 June 2021
...Hyungjoo Kim; Seogho Son; Yunhyo Ko; Jeong Eon Lee; Sangmin Kim; Incheol Shin ABSTRACT About 70% of breast cancers overexpress estrogen receptor α (ERα, encoded by ESR1 ). Tamoxifen, a competitive inhibitor of estrogen that binds to ER, has been widely used as a treatment for ER-positive breast...
Includes: Supplementary data
Journal Articles
J Cell Sci (2021) 134 (7): jcs252304.
Published: 15 April 2021
...(A) polymerase, poly(A) polymerase α (PAPOLA), in cancer, we assessed its expression in 221 breast cancer samples and found it to correlate strongly with the aggressive triple-negative subtype. Silencing PAPOLA in MCF-7 and MDA-MB-231 breast cancer cells reduced proliferation and anchorage-independent growth...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (9): jcs236125.
Published: 11 May 2020
...Ang Lu; Wei Wang; Shu-Fang Wang-Renault; Brian Z. Ring; Yoshimasa Tanaka; Jun Weng; Li Su ABSTRACT Human breast cancer cells exhibit considerable diversity in the methylation status of genomic DNA CpGs that regulate metastatic transcriptome networks. In this study, we identified human Sipa1...
Includes: Supplementary data
Journal Articles
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Stem Cells
J Cell Sci (2020) 133 (2): jcs232470.
Published: 23 January 2020
... – that not only affects the behavior of cells but also disrupts their ability to restore tissue integrity. While abnormal tissue properties, including increased extracellular matrix stiffness, are linked with the risk of developing breast cancer, the role and contribution of senescent MSCs to the disease...
Includes: Supplementary data
Journal Articles
J Cell Sci (2019) 132 (20): jcs232058.
Published: 23 October 2019
...Maitreyi Rathod; Sushmita Chatterjee; Shruti Dutta; Rajiv Kalraiya; Dibyendu Bhattacharyya; Abhijit De ABSTRACT Chasing an intriguing biological question on the disparity of sodium iodide symporter (NIS, officially known as SLC5A5) expression and function in the clinical scenario of breast cancer...
Includes: Supplementary data
Journal Articles
In collection:
Autophagy
J Cell Sci (2019) 132 (20): jcs234120.
Published: 22 October 2019
... inhibition of the SUMO pathway induces autophagy, apoptosis and cell death in a TRIB3-dependent manner. Moreover, we found that TRIB3, as well as other markers of the autophagy-mediated cell death pathway, are upregulated in vivo upon GA administration to mice bearing breast cancer xenografts. However...
Includes: Supplementary data
Journal Articles
J Cell Sci (2019) 132 (11): jcs223172.
Published: 05 June 2019
... in MDA-MB-231 breast cancer cells in which early endosomes demonstrated aberrantly enriched F-actin and accumulated the metalloproteinase MT1-MMP (also known as MMP14) upon DLC3 knockdown. Remarkably, Rab4 (herein referring to Rab4A) downregulation fully rescued the enhanced matrix degradation of TGF-β...
Includes: Supplementary data
Journal Articles
J Cell Sci (2018) 131 (21): jcs220640.
Published: 29 October 2018
... with poor prognosis. Here, we report that CD151 is involved in regulation of the expression of fibroblast growth factor receptor 2 (FGFR2). Depletion of CD151 in breast cancer cells resulted in an increased level of FGFR2. Accordingly, an inverse correlation between CD151 and FGFR2 was observed in breast...
Includes: Supplementary data
Journal Articles
J Cell Sci (2018) 131 (16): jcs212563.
Published: 23 August 2018
...Clara R. L. Oudenaarden; Robert A. H. van de Ven; Patrick W. B. Derksen ABSTRACT Metastatic breast cancer is responsible for most breast cancer-related deaths. Disseminated cancer cells have developed an intrinsic ability to resist anchorage-dependent apoptosis (anoikis). Anoikis is caused...
Journal Articles
J Cell Sci (2017) 130 (19): 3399–3413.
Published: 01 October 2017
... for CCL2, is implicated in cancer progression. However, we found that a higher CCR2 mRNA level is remarkably associated with prolonged survival of breast cancer patients. These conflicting results prompted us to study the non-coding function of CCR2 mRNA. We found that the CCR2 3′ untranslated region (UTR...
Includes: Supplementary data
Journal Articles
J Cell Sci (2017) 130 (14): 2292–2305.
Published: 15 July 2017
... and cell survival. Our studies identify the transient receptor potential canonical-1 (TRPC1) ion channel as a key component of responses to hypoxia in breast cancer cells. This regulation includes control of specific epithelial to mesenchymal transition (EMT) events and hypoxia-mediated activation...
Includes: Supplementary data
Journal Articles
In collection:
Adhesion
J Cell Sci (2017) 130 (13): 2172–2184.
Published: 01 July 2017
... identified the focal adhesion protein tensin3 (Tns3) as a determinant of adhesion plasticity. Tns3 is strongly reduced at mRNA and protein levels in suspension cells. Furthermore, by transiently challenging breast cancer cells to grow under non-adherent conditions markedly reduces Tns3 protein expression...
Includes: Supplementary data
Journal Articles
J Cell Sci (2017) 130 (4): 697–711.
Published: 15 February 2017
... cargoes, which we have used to determine that Rab17 controls Vamp8 levels to drive neuropilin-2 trafficking, promoting invasion. SILAC Rab17 Vamp8 Neuropilin-2 Ductal carcinoma in situ Invasive ductal carcinoma Late endosome Cell migration Invasion Breast cancer The membrane...
Includes: Supplementary data
Journal Articles
J Cell Sci (2017) 130 (1): 190–202.
Published: 01 January 2017
...) drive cancer progression and promote inflammation. Here, we show that the non-polarized breast cancer cell line T4-2 generates significantly higher ROS levels than polarized S1 and T4R cells in three-dimensional (3D) culture, accompanied by induction of the nuclear factor κB (NF-κB) pathway and cytokine...
Includes: Supplementary data
Journal Articles
J Cell Sci (2016) 129 (7): 1355–1365.
Published: 01 April 2016
... are important activities for invadopodia function. Importantly, we show that depletion of CD44s inhibits breast cancer cell metastasis to the lung in animals. These findings suggest a crucial mechanism underlying the role of the CD44s splice isoform in breast cancer metastasis. * Present address: College...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (21): 3961–3976.
Published: 01 November 2015
... control HDAC7 protein levels during acini formation. The first indication that the MEF2–HDAC axis contributes to mammary breast epithelial homeostasis resulted from the association of MEF2D expression with a better overall survival of individuals with breast cancer ( Fig. 1 A). Furthermore, MEF2D...
Includes: Supplementary data
Journal Articles
J Cell Sci (2014) 127 (21): 4692–4701.
Published: 01 November 2014
.... The appearance of these foci correlates with the process of P-body disassembly. A similar reduction in P-body count is also observed in human HER2-positive (HER2 + ) breast cancer cells overexpressing MLN51. This suggests that P-body disassembly and subsequent mRNA deregulation might correlate with cancer...
Includes: Supplementary data
Journal Articles
J Cell Sci (2014) 127 (18): 3893–3901.
Published: 15 September 2014
... cancer by acting in concert with Rab25 to regulate the recycling of α5β1 integrin from late endosomes to the plasma membrane. Here, we show that in two estrogen receptor (ER)-negative breast cancer cell lines, CLIC3 has little influence on integrin recycling, but controls trafficking of the pro-invasive...
Includes: Supplementary data