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1-4 of 4
Keywords: Brca2
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Journal Articles
Journal:
Journal of Cell Science
J Cell Sci (2015) 128 (4): 717–727.
Published: 15 February 2015
... that the recombination mediator Brca2 associates with lamin and the cohesion factor Pds5 to secure persistent recombination sites at the nuclear envelope. In Rad51 −/− females, all persistent DNA breaks are directed to the nuclear envelope. By contrast, a reduction of Pds5 or Brca2 levels abolishes the movement and has...
Includes: Supplementary data
Journal Articles
Journal:
Journal of Cell Science
J Cell Sci (2012) 125 (22): 5555–5563.
Published: 15 November 2012
... melanogaster Chk2 (a downstream kinase that initiates the meiotic checkpoint) rescues the cycG mutant eggshell phenotype. In vivo , CycG associates with Rad9 and BRCA2. These two proteins are components of the 9-1-1 complex, which is involved in sensing DSBs and in activating meiotic checkpoint control...
Includes: Supplementary data
Journal Articles
Journal:
Journal of Cell Science
J Cell Sci (2010) 123 (9): 1395–1400.
Published: 1 May 2010
...Sergey Lekomtsev; Julien Guizetti; Andrei Pozniakovsky; Daniel W. Gerlich; Mark Petronczki Germline mutations in the tumor-suppressor gene BRCA2 predispose to breast and ovarian cancer. BRCA2 plays a well-established role in maintaining genome stability by regulating homologous recombination. BRCA2...
Includes: Multimedia, Supplementary data
Journal Articles
Tomohiro Hayakawa, Fan Zhang, Noriyo Hayakawa, Yasuko Ohtani, Kaori Shinmyozu, Jun-ichi Nakayama, Paul R. Andreassen
Journal:
Journal of Cell Science
J Cell Sci (2010) 123 (7): 1124–1130.
Published: 1 April 2010
...Tomohiro Hayakawa; Fan Zhang; Noriyo Hayakawa; Yasuko Ohtani; Kaori Shinmyozu; Jun-ichi Nakayama; Paul R. Andreassen PALB2 physically and functionally connects the proteins encoded by the BRCA1 and BRCA2 breast and ovarian cancer genes into a DNA-damage-response network. However, it remains unclear...
Includes: Supplementary data