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Keywords: Bqt4
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Journal Articles

A ubiquitin–proteasome pathway degrades the inner nuclear membrane protein Bqt4 to maintain nuclear membrane homeostasis

In collection:
Proteostasis
Toan Khanh Le, Yasuhiro Hirano, Haruhiko Asakawa, Koji Okamoto, Tatsuo Fukagawa, Tokuko Haraguchi, Yasushi Hiraoka
Journal: Journal of Cell Science
J Cell Sci (2023) 136 (19): jcs260930.
https://doi.org/10.1242/jcs.260930
Published: 3 October 2023
... the maintenance of INM homeostasis remain poorly understood. In this study, we explored the degradation mechanisms of the INM protein Bqt4 in the fission yeast Schizosaccharomyces pombe . We have previously shown that Bqt4 interacts with the transmembrane protein Bqt3 at the INM and is degraded in the absence...
View articletitled, A ubiquitin–proteasome pathway degrades the inner nuclear membrane protein Bqt4 to maintain nuclear membrane homeostasis
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Includes: Supplementary data
Journal Articles

Ceramide synthase homolog Tlc4 maintains nuclear envelope integrity via its Golgi translocation

In collection:
Lipid biology , Nuclear structure and function
Yasuhiro Hirano, Yusuke Ohno, Yoshino Kubota, Tatsuo Fukagawa, Akio Kihara, Tokuko Haraguchi, Yasushi Hiraoka
Journal: Journal of Cell Science
J Cell Sci (2023) 136 (10): jcs260923.
https://doi.org/10.1242/jcs.260923
Published: 17 May 2023
... are involved in NE maintenance, but the underlying mechanism remains unclear. Here, we found that the ceramide synthase (CerS) homolog in the fission yeast Schizosaccharomyces pombe Tlc4 (SPAC17A2.02c) suppressed NE defects in cells lacking the NE proteins Lem2 and Bqt4. Tlc4 possesses a TRAM/LAG1/CLN8 domain...
View articletitled, Ceramide synthase homolog Tlc4 maintains nuclear envelope integrity via its Golgi translocation
Open the PDF for Ceramide synthase homolog Tlc4 maintains nuclear envelope integrity via its Golgi translocation in another window
Includes: Supplementary data