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Keywords: Bone resorption
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Journal Articles
J Cell Sci (2021) 134 (22): jcs259040.
Published: 26 November 2021
... fail to form tight sealing zones, showing that kindlin-3 is not only crucial for osteoclast adhesion to the bone surface but is also essential for the organization of adhesion structures. Kindlin-3 Osteoclast Integrin Podosome Sealing zone Bone resorption Max-Planck-Gesellschaft...
Includes: Supplementary data
Journal Articles
J Cell Sci (2019) 132 (10): jcs229351.
Published: 15 May 2019
.... They proved to be identical to reversal cells and are believed to differentiate into bone-forming osteoblasts thereby coupling resorption and formation. However, they also exert catabolic activity that contributes to osteoclastic bone resorption, but this has not received much attention. Herein, we used co...
Includes: Supplementary data
Journal Articles
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J Cell Sci (2017) 130 (12): 2026–2035.
Published: 15 June 2017
... of this phenotype is the organization of podosomes in a sealing zone (SZ) ( Luxenburg et al., 2007 ; Saltel et al., 2004 ), which is believed to immobilize the OC and seal-off an extracellular bone resorption compartment; this SZ surrounds the ruffled border, which covers the resorption compartment and mediates...
Includes: Supplementary data
Journal Articles
J Cell Sci (2013) 126 (4): 1032–1045.
Published: 15 February 2013
...) and the mineralized surface (MS/BS) showed no significant differences between the mice ( Fig. 1C ). More importantly, the bone histomorphometric analysis showed significant decreases in parameters associated with bone resorption, such as osteoclast numbers (N.Oc./B.Pm) and osteoclast surface areas (Oc.S/BS) ( Fig. 1D...
Journal Articles
J Cell Sci (2009) 122 (1): 136–144.
Published: 1 January 2009
... of PKC to the basolateral membrane domain of osteoclasts, an aspect of spatiotemporal signaling not previously recognized. * Author for correspondence (e-mail: stephen.sims@schulich.uwo.ca ) 27 9 2008 © The Company of Biologists Limited 2009 2009 Bone resorption Cytosolic Ca 2...
Includes: Multimedia, Supplementary data