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Keywords: Bone morphogenetic proteins
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Journal Articles

Oocytes prevent cumulus cell apoptosis by maintaining a morphogenic paracrine gradient of bone morphogenetic proteins

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Tamer S. Hussein, David A. Froiland, Fred Amato, Jeremy G. Thompson, Robert B. Gilchrist
Journal: Journal of Cell Science
J Cell Sci (2005) 118 (22): 5257–5268.
https://doi.org/10.1242/jcs.02644
Published: 15 November 2005
... of the oocyte(s). Growth differentiation factor 9 (GDF9) had no significant effect on cumulus cell apoptosis. By contrast, cumulus cell apoptosis was significantly (P< 0.001) reduced by bone morphogenetic proteins (BMP) 15, 6 or 7. Accordingly, levels of anti-apoptotic Bcl-2 were high in OOX+DO and OOX+BMP15...
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Journal Articles

Bone morphogenetic proteins promote development of fetal pancreas epithelial colonies containing insulin-positive cells

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Fang-Xu Jiang, Edouard G. Stanley, L. Jorge Gonez, Leonard C. Harrison
Journal: Journal of Cell Science
J Cell Sci (2002) 115 (4): 753–760.
https://doi.org/10.1242/jcs.115.4.753
Published: 15 February 2002
... matrix protein laminin-1, bone morphogenetic proteins (BMPs-4, -5 and -6)promote the development of cystic epithelial colonies. Transforming growth factor β1 (TGF-β1) and activin A antagonise this effect of BMP-6 and inhibit colony formation. Histological analysis revealed that the colonies are composed...
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