... the blood–brain barrier (BBB) is a critical step in central nervous system (CNS) immune surveillance and inflammation. Whereas T cell diapedesis across the intact BBB seems to occur preferentially through the BBB cellular junctions, impaired BBB integrity during neuroinflammation is accompanied by increased...

.... and Bateman , J. M. ( 2012 ). Concerted control of gliogenesis by InR/TOR and FGF signalling in the Drosophila post-embryonic brain . Development   139 , 2763 - 2772 . 10.1242/dev.074179 Babatz , F. , Naffin , E. and Klämbt , C. ( 2018 ). The Drosophila blood-brain barrier adapts...

... to neuroinflammatory diseases. Blood–brain barrier (BBB) dysfunction is a hallmark phenotype of neuroinflammation. It is known that IL-1β directly induces BBB hyperpermeability but the mechanisms remain unclear. Claudin-5 (Cldn5) is a tight junction protein found at endothelial cell–cell contacts that are crucial...

... the integrity of the blood–brain barrier (BBB). Here, we show that K104Stop-MCP1, truncated at the K104 where plasmin would normally cleave, is more efficient than the full-length protein (FL-MCP1) in compromising the integrity of the BBB in in vitro and in vivo models. K104Stop-MCP1 increases the permeability...

... © The Company of Biologists Limited 2009 2009 Tgfβ αvβ8 integrin Angiogenesis Blood-brain barrier Extracellular matrix Neural stem cell The vertebrate CNS contains an elaborate network of blood vessels that intimately associate with neuronal and glial elements to form integrated...

... plasminogen activator (tPA). tPA mediates neurotoxic effects on resident central nervous system cells as well alters blood-brain barrier (BBB) permeability, which further promotes neurodegeneration. Another signaling molecule that promotes neurodegeneration and BBB dysfunction is nitric oxide (NO), although...

... receptor-related protein 1 (LRP1) and LDL receptor-related protein 2 (LRP2 or megalin), possess the ability to mediate transcytosis of ligands across the brain capillary endothelium. Here, we tested whether blood-borne RAP crosses the blood-brain barrier (BBB) by LRP1- or megalin-mediated transport...

...Beatrice Nico; Antonio Frigeri; Grazia Paola Nicchia; Fabio Quondamatteo; Rainer Herken; Mariella Errede; Domenico Ribatti; Maria Svelto; Luisa Roncali ABSTRACT In this study, we have investigated the expression of aquaporin 4 during blood-brain barrier development in the optic tectum of chick...

...William A. Banks; Victoria Akerstrom; Abba J. Kastin ABSTRACT HIV-1 induces the AIDS dementia complex and infects brain endothelial and glial cells. Because the endothelial cells comprising the blood-brain barrier (BBB) do not possess CD4 receptors or galactosylceramide binding sites, it is unclear...

... is prevented by the endothelial tight junction, the permeability of which varies enormously depending on tissue. Endothelial cells of the blood-brain barrier possess tight junctions of severely limited permeability, whereas those of non-neural tissue are considerably leakier, but the molecular basis...

...Hartwig Wolburg; Jochen Neuhaus; Uwe Kniesel; Bodo Krauß; Eva-Maria Schmid; Mücella Öcalan; Catherine Farrell; Werner Risau ABSTRACT Tight junctions between endothelial cells of brain capillar- ies are the most important structural elements of the blood- brain barrier. Cultured brain endothelial...

... components. In this study we report the localization of some adherens junction components in intact microvessels of the blood-brain barrier in the rat. We used antibodies raised against α -actinin, vinculin, zyxin, cadherin (antipan-cadherin antibody) and A-CAM (N-cadherin) in immunohistochemical experiments...

... in order to test whether this serum inducing agent (SIA) also regulates sialoadhesin expression in vivo and whether plasma proteins may influence the phenotype of macrophages of the nervous system. Microglia, the resident macrophages of the central nervous system, reside behind the blood-brain barrier...

... for correspondence 20 03 1990 29 05 1990 © 1990 by Company of Biologists 1990 blood-brain barrier brain endocytosis endothelial cell microvessel recycling ricin agglutinin trans-Golgi network The capillary endothelium that contributes to the bloodbrain barrier (BBB...