... is typically reliant on bleb formation. Here we demonstrate that thrombin induces dynamic blebbing in the MDA-MB-231 breast cancer cell line and confirm that protease-activated receptor 1 (PAR1) activation is sufficient to induce this effect. Cell confinement has been implicated as a driving force in bleb...

...Indranil Ghosh; Raman K. Singh; Manjari Mishra; Shobhna Kapoor; Siddhartha S. Jana ABSTRACT Cells can adopt both mesenchymal and amoeboid modes of migration through membrane protrusive activities, namely formation of lamellipodia and blebbing. How the molecular players control the transition...

...+ -activated RhoA. Such cells could potentially be used to target senescence. IL6 receptor IL6 Chimeras Ca 2+ signaling Blebbing Migration Protein engineering Synthetic biology Cells undergoing senescence not only exhibit arrest of cell proliferation, but also changes in protein...

... are cleared by endocytosis. However, the experiments reported here failed to reveal any evidence for endocytosis of SLO, nor did they reveal any signs of damage to endosomal membranes predicted from such endocytosis. Instead, we illustrate that SLO induces a characteristic form of plasma membrane blebbing...

...Dhianjali Chandraratna; Nicola Lawrence; David P. Welchman; Bénédicte Sanson The apoptotic phenotype is characterised by dynamic changes in cell behaviours such as cell rounding and blebbing, followed by chromatin condensation and cell fragmentation. Whereas the biochemical pathways leading...

... that astrocytes exposed to ethanol undergo morphological changes associated with anoikis, including the peripheral reorganization of both focal adhesions and actin-myosin system, cell contraction, membrane blebbing and chromatin condensation. We found that either the small GTPase RhoA or its effector ROCK-I (Rho...

...Jon D. Lane; Victoria J. Allan; Philip G. Woodman Plasma membrane blebbing is a defining characteristic of apoptosis, but its significance is not understood. Using live-cell imaging we have identified two phases of apoptotic blebbing. The early phase is restricted to adherent cells...