... approaches, we investigated how mitochondrial dynamics and physiology adapt to radiation stress and uncover a novel role for Fis1, a pro-fission protein, in regulating the stress response through mitochondrial DNA (mtDNA) maintenance and altered mitochondrial bioenergetics. Importantly, our data demonstrate...

...Sabrina M. Holland; Gianluca Gallo ABSTRACT The regulation of the intracellular level of ATP is a fundamental aspect of bioenergetics. Actin cytoskeletal dynamics have been reported to be an energetic drain in developing neurons and platelets. We addressed the role of actin dynamics in primary...

...Nioosha Nekooie Marnany; Redouane Fodil; Sophie Féréol; Alwyn Dady; Marine Depp; Frederic Relaix; Roberto Motterlini; Roberta Foresti; Jean-Loup Duband; Sylvie Dufour ABSTRACT Bioenergetic metabolism is a key regulator of cellular function and signaling, but how it can instruct the behavior...

... work is properly attributed. Highlighted Article: Cancer-associated fibroblasts impart a migratory advantage onto already highly invasive breast cancer cell spheroids owing, in part, to mitochondrial transfer via tunneling nanotubes and the associated bioenergetic rewiring. Reverse...

... contributes to mitochondrial quality control and responds to various metabolic pathways, such as autophagy, cell death and bioenergetics ( Herrera-Cruz and Simmen, 2017 ; Prudent and McBride, 2017 ), that are closely linked to the maintenance of health or the occurrence of disease ( Yapa et al., 2021...

... of the nervous system in humans. Regulation of mitochondrial dynamics is partly accomplished through post-translational modification of mitochondrial fission and fusion enzymes, in turn influencing mitochondrial bioenergetics and transport. The importance of post-translational regulation is highlighted...