... cells require αvβ5 integrin receptors for particle binding that triggers engulfment. Here, we show that tetraspanins CD81 and CD9 reside in a complex specifically with αvβ5 integrin but not the engulfment receptors Mer tyrosine kinase and CD36 at the apical, phagocytic surface of RPE cells. Function...

... with the characteristics of full-length UCP1. Deletion of the second repeat of UCP1 completely abolished all import into the mitochondria. Consistent with this, the central repeat alone was efficiently imported to the inner membrane and bound hTom20 with the characteristics of UCP1. We conclude that the site for binding...

...Mario Gimona; Zeev Lando; Yakov Dolginov; Joel Vandekerckhove; Ryuji Kobayashi; Apolinary Sobieszek; David M. Helfman ABSTRACT Zero-length chemical crosslinking with 1-ethyl-3-[3-(dimethyl amino)propyl]carbodiimide (EDC) indicated an association of the Ca 2+ -binding protein S100A2 with tropomyosin...

...P. Dvořák; J.-E. Flechon; E. M. Thompson; V. Horák; P. Adenot; J. P. Renard ABSTRACT Several peptide growth factors, including members of the fibroblast growth factor (FGF) superfamily, are potential inducers of mesoderm in vertebrates. Receptor binding of basic FGF (FGF-2) is promoted by cell...

...Don F. Cameron; Karl E. Muffly ABSTRACT A Sertoli-spermatid coculture model is described in which a large percentage (>76%) of round spermatids remain viable for 48 h and bind to Sertoli cells. The effects of follicle-stimulating hormone (FSH) and testosterone on spermatid binding (expressed...