... by The Company of Biologists Ltd 2023 Summary: A review of the molecular mechanism of MOMP, with a focus on recently discovered roles of BCL-2 proteins in apoptosis and beyond, including what implications these might have in both healthy tissues and disease. BCL2 Apoptosis Mitochondria MOMP BAX...

.... We further showed that the HuR depletion had no influence on the mRNA level of the anti-apoptotic gene BCL2 , but instead that HuR downregulates BCL2 translation in a cap-independent way. Polysome fractionation studies showed that HuR retarded the BCL2 mRNA in the non-translating pool of polysomes...

...Richa Singh; Neeru Saini A number of anti-cancer strategies aim to target the mitochondrial apoptotic machinery to induce tumour cell death. Mitochondria play a key role as death amplifiers by releasing apoptogenic factors from the mitochondrial inter-membrane space into the cytosol. BCL2 proteins...

... domain of VDAC1 controls the release of cytochrome c , apoptosis and the regulation of apoptosis by anti-apoptotic proteins such as hexokinase and Bcl2. Cells expressing N-terminal truncated VDAC1 do not release cytochrome c and are resistant to apoptosis, induced by various stimuli. Employing a variety...

.... elegans BCL2 homolog CED-9 affects both mitochondrial fission and fusion. Although striated muscle cells lacking CED-9 have no alteration in mitochondrial size or ultrastructure, these cells appear more sensitive to mitochondrial fragmentation. By contrast, increased CED-9 expression in these cells...

...Leigh Coultas; Susanna Terzano; Tim Thomas; Anne Voss; Kate Reid; Edouard G. Stanley; Clare L. Scott; Philippe Bouillet; Perry Bartlett; Jonathan Ham; Jerry M. Adams; Andreas Strasser The pro-apoptotic BH3-only members of the Bcl2 family, crucial initiators of cell death, are activated by a diverse...

... localization of rp3, whereas rp3 and dynein motor activity are not essential for nuclear accumulation of SATB1. The nuclear rp3-SATB1 protein complex is assembled with a DNA element of the matrix attachment region of the Bcl2 gene. Finally, rp3 is involved in SATB1-mediated gene repression of Bcl2 . Our data...

... for correspondence (e-mail: [email protected] .) 27 5 2003 © The Company of Biologists Limited 2003 2003 Toxoplasma gondii Apoptosis NF-κB IκB Bcl2 IAP Toxoplasma gondii is an obligate intracellular protozoan belonging to the phylum Apicomplexa that causes opportunistic disease...

...Yong J. Lee; Jenn C. Chen; Andrew A. Amoscato; Jaafar Bennouna; Douglas R. Spitz; Mohan Suntharalingam; Juong G. Rhee ABSTRACT Previous studies have shown that overexpression of Bcl2 protects cells from glucose deprivation-induced cell death in multidrug-resistant human breast carcinoma, MCF-7/ADR...