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Keywords: Basement membrane
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Polarity
J Cell Sci (2021) 134 (22): jcs258905.
Published: 23 November 2021
...Yuina Hirose; Yohei Hirai ABSTRACT Mammary epithelia undergo dramatic morphogenesis after puberty. During pregnancy, luminal epithelial cells in ductal trees are arranged to form well-polarized cystic structures surrounded by a myoepithelial cell layer, an active supplier of the basement membrane...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (18): jcs239889.
Published: 16 September 2020
...Claire Leclech; Carlo F. Natale; Abdul I. Barakat ABSTRACT The basement membrane (BM) is a thin specialized extracellular matrix that functions as a cellular anchorage site, a physical barrier and a signaling hub. While the literature on the biochemical composition and biological activity of the BM...
Includes: Supplementary data
Journal Articles
J Cell Sci (2019) 132 (7): jcs226860.
Published: 08 April 2019
...Angela M. Howard; Kimberly S. LaFever; Aidan M. Fenix; Cherie' R. Scurrah; Ken S. Lau; Dylan T. Burnette; Gautam Bhave; Nicholas Ferrell; Andrea Page-McCaw ABSTRACT Basement membranes are an ancient form of animal extracellular matrix. As important structural and functional components of tissues...
Includes: Supplementary data
Journal Articles
J Cell Sci (2017) 130 (19): 3203–3211.
Published: 01 October 2017
... signals that pattern the surrounding tissues. It is composed of a core of vacuolated cells surrounded by an epithelial-like sheath of cells that secrete a thick peri-notochordal basement membrane made of different extracellular matrix (ECM) proteins. The correct deposition and organization of the ECM...
Journal Articles
J Cell Sci (2016) 129 (13): 2586–2598.
Published: 01 July 2016
... known as MMP14) cell surface exposure at podosome sites. We hypothesise that by promoting podosome formation, VEGF-A enables endothelial cells to overcome the basement membrane barrier to allow sprouting outwards from the existing vasculature. * Present address: Department of Biomedecine...
Includes: Supplementary data
Journal Articles
J Cell Sci (2014) 127 (15): 3217–3225.
Published: 01 August 2014
... inside-out signals to polarise basement membrane assembly at the basal surface, and outside-in signals to control microtubule apical–basal orientation and vesicular trafficking are required for establishing and maintaining the orientation of epithelial cell polarity. Finally, we discuss the relevance...
Journal Articles
J Cell Sci (2012) 125 (19): 4609–4619.
Published: 01 October 2012
...Karen K. McKee; Dong-Hua Yang; Rajesh Patel; Zu-Lin Chen; Sidney Strickland; Junichi Takagi; Kiyotoshi Sekiguchi; Peter D. Yurchenco Summary Laminins promote early stages of peripheral nerve myelination by assembling basement membranes (BMs) on Schwann cell surfaces, leading to activation of β1...
Includes: Supplementary data
Journal Articles
J Cell Sci (2012) 125 (18): 4241–4252.
Published: 15 September 2012
... and differentiate to form a stratified epithelium. Using a comparative proteomic approach, we studied this ‘confluence switch’ and identified a new pathway triggered by cell confluence that regulates basement membrane (BM) protein composition by suppressing the uPA–uPAR–plasmin pathway. Indeed, confluence triggers...
Includes: Supplementary data
Journal Articles
J Cell Sci (2011) 124 (17): 2927–2937.
Published: 01 September 2011
... are heterotrimeric glycoproteins of the extracellular matrix that are secreted by epithelial cells and which are crucial for the normal structure and function of the basement membrane. We have generated a mouse harboring a conditional knockout of α3 laminin ( Lama3 fl/fl ), one of the main laminin subunits...
Includes: Supplementary data
Journal Articles
J Cell Sci (2008) 121 (15): 2493–2502.
Published: 01 August 2008
.... The colon also contains crypts of Lieberkühn, but its epithelial surface is lined by flat surface cuffs. The epithelial cells of both organs communicate with the underlying mesenchyme through a basement membrane that is composed of a variety of extracellular matrix proteins, including members...
Includes: Supplementary data
Journal Articles
J Cell Sci (2006) 119 (7): 1396–1405.
Published: 01 April 2006
... microenvironment. The basement membrane molecule, laminin-5 (LN-5), is predominantly found in the medulla of the human thymic lobules. Using high-resolution light microscopy, we show here that LN-5 is localized in a bi-membranous conduit-like structure, together with other typical basement membrane components...
Journal Articles
J Cell Sci (2006) 119 (4): 625–635.
Published: 15 February 2006
... the LH activity of LH3 developed normally, but showed defects in the structure of the basement membrane and in collagen fibril organization in newborn skin and lung. Analysis of a hypomorphic LH3 mouse line with the same mutation, however, demonstrated that the reduction of the GGT activity of LH3...
Journal Articles
J Cell Sci (2004) 117 (24): 5913–5922.
Published: 15 November 2004
..., but not of laminin and nidogen-1, in the basement membrane (BM). Electron immunomicroscopy revealed accumulation of type IV collagen in dilated ERs, but not in the BM of Hsp47 –/– embryos, whereas it was only present in the BM in Hsp47 +/+ embryos. The BM structures stained with anti-laminin and anti-nidogen-1...
Journal Articles
J Cell Sci (2004) 117 (12): 2611–2622.
Published: 15 May 2004
...Dirk Breitkreutz; Nicolae Mirancea; Cathrine Schmidt; Regina Beck; Ulrich Werner; Hans-Jürgen Stark; Martin Gerl; Norbert E. Fusenig Basement membranes generally determine different tissue compartments in complex organs, such as skin, playing not only an important structural but also a regulatory...
Journal Articles
J Cell Sci (2004) 117 (5): 735–742.
Published: 15 February 2004
...Peter D. Yurchenco; Yi-Shan Cheng; Kevin Campbell; Shaohua Li Basement membrane laminins bearing the α2-subunit interact with α-dystroglycan and β1-integrins, cell-surface receptors that are found within the rectilinear costameric lattices of skeletal muscle sarcolemma. Mutations of the α2 subunit...
Journal Articles
J Cell Sci (2004) 117 (2): 233–242.
Published: 15 January 2004
...Gautam Bhattacharya; Raghu Kalluri; Dana J. Orten; William J. Kimberling; Dominic Cosgrove Usherin is a basement membrane protein encoded by the gene associated with Usher syndrome type IIa, the most common deaf/blind disorder. This report demonstrates a specific interaction between type IV...
Journal Articles
J Cell Sci (2003) 116 (14): 2975–2986.
Published: 15 July 2003
... cells were placed on tissue culture plastic; however, the presence of a reconstituted basement membrane in combination with lactogenic hormones partially prevented this decrease. Estrogen receptor αexpression in primary mammary fibroblasts was not altered by these culture conditions, indicating that its...
Journal Articles
J Cell Sci (2002) 115 (13): 2747–2756.
Published: 01 July 2002
...Qi Yan; John I. Clark; Thomas N. Wight; E. Helene Sage The lens capsule, which is also called the lens basement membrane, is a specialized extracellular matrix produced anteriorly by the lens epithelium and posteriorly by newly differentiated fiber cells. SPARC (secreted protein,acidic and rich...
Journal Articles
J Cell Sci (1991) 1991 (Supplement_15): 9–12.
Published: 01 February 1991
...DAVID EDGAR Summary The extracellular matrix glycoprotein laminin exerts profound effects on the survival and differentiation of neurons in vitro . Although principally confined to the basement membranes of the adult extracellular matrix, during development laminin immunoreactivity may be found...