...Tomohito Higashi; Rachel E. Stephenson; Cornelia Schwayer; Karla Huljev; Atsuko Y. Higashi; Carl-Philipp Heisenberg; Hideki Chiba; Ann L. Miller ABSTRACT Epithelial barrier function is commonly analyzed using transepithelial electrical resistance, which measures ion flux across a monolayer...

... dynamically remodel in response to physiological forces that challenge epithelial barrier function, such as cell shape changes (e.g. during cell division) or tissue stretching (e.g. during developmental morphogenesis). In this Review, we first introduce a framework to think about TJ remodeling across multiple...

... of barrier function. The epithelial barrier is compromised under pathological conditions that are driven by infectious, ischemic or immune-derived stimuli. As a result, barrier loss can be detected as increased flux across the pore pathway, the leak pathway or the unrestricted pathway. The latter is a tight...

...Michaela T. Niessen; Sandra Iden; Carien M. Niessen Summary The establishment and maintenance of cell and tissue polarity is crucial for a range of biological processes, such as oriented division, migration, adhesion and barrier function. The molecular pathways that regulate cell and tissue...

... and Sun, 1990 ; Mullin and Snock, 1990 ; Mankertz et al., 2000 ; Schmitz et al., 1999 ). A number of recent studies have focused on altered barrier function during active IBD ( Hollander et al., 1986 ; Mankertz and Schulzke, 2007 ) and have identified perturbation of the tight junction (TJ...

... blotting * Author for correspondence (e-mail: [email protected] ) 5 1 2004 © The Company of Biologists Limited 2004 2004 Barrier function Cathepsin D Cornified envelope Epidermal differentiation Involucrin Loricrin Filaggrin Keratin Sphingomyelinase...

... © 1997 by Company of Biologists 1997 Keratin 10 knockout mouse Epidermal differentiation Epidermolytic hyperkeratosis Keratin 2e Keratin 6 Filaggrin Barrier function Transgenic and knockout mice have been valuable in unraveling the functional significance of many proteins...