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Keywords: BRCA1
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Journal Articles
J Cell Sci (2021) 134 (15): jcs258601.
Published: 09 August 2021
... downregulated multiple key targets in the DNA damage response (DDR) pathway, namely BRCA1, ATM, Chk1 (also known as CHEK1) and RNF8. CDX2 directly regulated the DDSMs, which led to increased tumor volume and metastasis in multiple preclinical models. In colon cancer patient tissues, the DDSMs negatively...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (3): jcs233437.
Published: 12 February 2020
... reporter, irradiation-induced focus formation and colony formation assays, we show that USP9X is required for efficient HR. Mechanistically, we show USP9X is important to sustain the expression levels of key HR factors, namely BRCA1 and RAD51 through a non-canonical regulation of their mRNA abundance...
Includes: Supplementary data
Journal Articles
J Cell Sci (2017) 130 (19): 3347–3359.
Published: 01 October 2017
...Douglas R. Mackay; Amanda C. Howa; Theresa L. Werner; Katharine S. Ullman ABSTRACT DNA double-strand breaks are typically repaired through either the high-fidelity process of homologous recombination (HR), in which BRCA1 plays a key role, or the more error-prone process of non-homologous end...
Includes: Supplementary data
Journal Articles
J Cell Sci (2016) 129 (23): 4366–4378.
Published: 01 December 2016
... of human variants detected by genome sequencing is a medical challenge. The yeast Saccharomyces cerevisiae model has held attention for its capacity to monitor the functional impact of missense mutations found in human genes, including the BRCA1 breast and ovarian cancer susceptibility gene. When expressed...
Includes: Supplementary data
Journal Articles
J Cell Sci (2012) 125 (24): 6049–6057.
Published: 15 December 2012
... significance of its interaction with the BRCA1 breast cancer susceptibility protein, are poorly understood. Here, to better understand these processes, we fused PALB2, or the PALB2(L21P) mutant which cannot bind to BRCA1, with the BRCT repeats that are present in, and which localize, BRCA1. Our results yield...
Includes: Supplementary data
Journal Articles
J Cell Sci (2012) 125 (15): 3529–3534.
Published: 01 August 2012
... on damaged chromatin actually relates to DNA repair remains unclear. Here, we use super-resolution microscopy to examine the spatial distribution of BRCA1 and 53BP1 proteins within single IRIF at subdiffraction-limit resolution, yielding an unprecedented increase in detail that was not previously apparent...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2010) 123 (7): 1124–1130.
Published: 01 April 2010
...Tomohiro Hayakawa; Fan Zhang; Noriyo Hayakawa; Yasuko Ohtani; Kaori Shinmyozu; Jun-ichi Nakayama; Paul R. Andreassen PALB2 physically and functionally connects the proteins encoded by the BRCA1 and BRCA2 breast and ovarian cancer genes into a DNA-damage-response network. However, it remains unclear...
Includes: Supplementary data
Journal Articles
J Cell Sci (2009) 122 (14): 2446–2452.
Published: 15 July 2009
... of unsynapsed chromatin (MSUC). MSUC is initiated by the recruitment of the tumor suppressor protein BRCA1 to the axes of unsynapsed chromosomes. We now show that Sycp3, a structural component of the chromosome axis, is required for localization of BRCA1 to unsynapsed pachytene chromosomes. Importantly, we find...
Includes: Supplementary data
Journal Articles
J Cell Sci (2005) 118 (14): 3173–3183.
Published: 15 July 2005
... was associated with increased p21 levels but p53 levels remained unchanged. In addition, expression of BRCA1 was downregulated, at both mRNA and protein levels. The observed effects of hnRNP A2 and its isoforms on cell proliferation and their correlation with BRCA1 and p21 expression suggest that these hnRNP...