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Keywords: BMP
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Journal Articles
J Cell Sci (2019) 132 (14): jcs234039.
Published: 15 July 2019
... to different TGF-β family ligands reveals distinct signalling dynamics driven by receptor localisation, which may underlie their biological function. TGF-β BMP Activin Signalling dynamics SMAD6/7 Receptor trafficking The transforming growth factor β (TGF-β) family of ligands plays diverse...
Includes: Supplementary data
Journal Articles
J Cell Sci (2017) 130 (14): 2344–2358.
Published: 15 July 2017
.... Functionally, timp null mutants exhibit compromised synaptic vesicle cycling, with activity that is lower in amplitude and fidelity. NMJ defects manifest in impaired locomotor function. Mechanistically, we find that Timp limits BMP trans -synaptic signaling and the downstream synapse-to-nucleus signal...
Includes: Supplementary data
Journal Articles
J Cell Sci (2016) 129 (7): 1477–1489.
Published: 1 April 2016
... expression is triggered when Gliotactin is overexpressed, leading to activation of the BMP signalling pathway. Gliotactin specifically interferes with Dad, an inhibitory SMAD, leading to activation of the Tkv type-I receptor and activation of Mad to elevate the biogenesis and expression of miR-184...
Includes: Supplementary data
Journal Articles
J Cell Sci (2016) 129 (1): 206–218.
Published: 1 January 2016
...Andreas Benn; Clara Bredow; Isabel Casanova; Slobodan Vukičević; Petra Knaus ABSTRACT Several vascular disorders, such as aberrant angiogenesis, atherosclerosis and pulmonary hypertension, have been linked to dysfunctional BMP signaling. Vascular hyperpermeability via distortion of endothelial cell...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (7): 1308–1315.
Published: 1 April 2015
...Jonathan W. Lowery; Giuseppe Intini; Laura Gamer; Sutada Lotinun; Valerie S. Salazar; Satoshi Ote; Karen Cox; Roland Baron; Vicki Rosen ABSTRACT Imbalances in the ratio of bone morphogenetic protein (BMP) versus activin and TGFβ signaling are increasingly associated with human diseases yet...
Includes: Supplementary data
Journal Articles
J Cell Sci (2014) 127 (23): 5027–5037.
Published: 1 December 2014
... reduced cranial cartilages. Genetic data link these phenotypes to insulin-like growth factor (Igf)-binding protein-3 (Igfbp-3) and bone morphogenetic protein (Bmp) signaling, and biochemical analysis show specific Igfbp-3 proteolysis by Papp-a2, implicating Papp-a2 in the modulation of Bmp signaling...
Journal Articles
J Cell Sci (2013) 126 (21): 4974–4984.
Published: 1 November 2013
...Valerie S. Salazar; Nicholas Zarkadis; Lisa Huang; Jin Norris; Susan K. Grimston; Gabriel Mbalaviele; Roberto Civitelli Summary To examine interactions between bone morphogenic protein (BMP) and canonical Wnt signaling during skeletal growth, we ablated Smad4 , a key component of the TGF-β–BMP...
Includes: Supplementary data
Journal Articles
J Cell Sci (2013) 126 (1): 234–243.
Published: 1 January 2013
... and regulating the output of various signaling pathways. Although Jab1 can interact with the bone morphogenetic protein (BMP) downstream effector Smad5 to repress BMP signaling in vitro , the role of Jab1 in BMP-mediated skeletogenesis in vivo is still poorly understood. As a key regulator of skeletogenesis, BMP...
Includes: Supplementary data
Journal Articles
J Cell Sci (2012) 125 (16): 3752–3764.
Published: 15 August 2012
... is regulated. Activation of the Bone Morphogenetic Protein (BMP) pathway at the Drosophila larval neuromuscular junction results in nuclear accumulation of the phosphorylated form of the transcription factor Mad in the motoneuron nucleus. This in turn regulates transcription of genes that control synaptic...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2011) 124 (20): 3399–3404.
Published: 15 October 2011
...Mohammed I. Ahmed; Andrei N. Mardaryev; Christopher J. Lewis; Andrey A. Sharov; Natalia V. Botchkareva Bone morphogenetic proteins (BMPs) play essential roles in the control of skin development, postnatal tissue remodelling and tumorigenesis. To explore whether some of the effects of BMP signalling...
Includes: Supplementary data
Journal Articles
J Cell Sci (2011) 124 (11): 1867–1877.
Published: 1 June 2011
... proliferating cultures can overcome this block, enabling continuous propagation of undifferentiated rat NS cells. We found that dormancy is induced by autocrine production of bone morphogenetic proteins (BMPs). Accordingly, the BMP antagonist noggin can replace conditioned medium to sustain continuous self...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2009) 122 (19): 3566–3578.
Published: 1 October 2009
... 2009 Axin2 β-catenin BMP Osteoblast Bone remodeling The Wnt family consists of a number of small, cysteine-rich, secreted glycoproteins that are involved in the regulation of a variety of cellular activities that are crucial for development ( Huelsken and Birchmeier, 2001 ; Moon et al...
Includes: Supplementary data
Journal Articles
J Cell Sci (2008) 121 (23): 3960–3970.
Published: 1 December 2008
...Cristina Gamell; Nelson Osses; Ramon Bartrons; Thomas Rückle; Montserrat Camps; José Luis Rosa; Francesc Ventura Bone morphogenetic proteins (BMPs) are potent regulators of several cellular events. We report that exposure of C2C12 cells to BMP2 leads to an increase in cell migration and a rapid...
Journal Articles
J Cell Sci (2008) 121 (6): 737–746.
Published: 15 March 2008
... progressively, offering new perspectives on their function and mechanism of action in both development and disease. These studies indicate that SFRPs are not merely Wnt-binding proteins, but can also antagonise one another's activity, bind to Fz receptors and influence axon guidance, interfere with BMP...
Journal Articles
J Cell Sci (2007) 120 (8): 1350–1357.
Published: 15 April 2007
..., a bHLH transcription factor, suppresses bone morphogenetic protein (BMP)-induced osteoblast differentiation, and downregulation of endogenous Twist-1 enhances BMP signaling. Maximal inhibition of BMP signaling was observed when Twist-1 was bound to E47, which markedly enhanced the stability of Twist-1...
Journal Articles
J Cell Sci (2007) 120 (7): 1216–1224.
Published: 1 April 2007
... signaling by recruiting and presenting Smad2/3 to the receptor complex. SARA does not bind Smad1 and hence does not enhance bone morphogenetic protein (BMP) signaling. Here we report for the first time that the endosome-associated FYVE-domain protein endofin acts as a Smad anchor for receptor activation...
Journal Articles
J Cell Sci (2007) 120 (6): 964–972.
Published: 15 March 2007
...-receptor endoglin play an important role in vascular development and angiogenesis. Here, we demonstrate that ALK1 is a signalling receptor for bone morphogenetic protein-9 (BMP-9) in endothelial cells (ECs). BMP-9 bound with high affinity to ALK1 and endoglin, and weakly to the type-I receptor ALK2...
Journal Articles
J Cell Sci (2005) 118 (16): 3573–3584.
Published: 15 August 2005
... for a `Smad-independent' pathway downstream of TGF-β, activin or BMP receptors has been proposed, the link between the activated receptor complex and the cytoplasmic effector molecule remains to be elucidated. Below, we review the most prominent examples of non-Smad signalling whose physical links...
Journal Articles
J Cell Sci (2003) 116 (10): 2015–2028.
Published: 15 May 2003
... collagen, with a surface cell layer expressing type I collagen. In contrast, noggin inhibited both the TGFβ- and TGFβ+PDGF-stimulated cartilage formation, suggesting that a BMP-dependent pathway is involved. In fact, replacement of TGFβ3 with BMP4 on days 10 to 12 markedly elevated the cartilage matrix...
Journal Articles
J Cell Sci (2002) 115 (4): 769–781.
Published: 15 February 2002
... into the chondrogenic lineage in vitro and in vivo after transplantation into muscle. A dominant-negative variant of Brachyury , consisting of its DNA-binding domain (T-box), interferes with BMP2-mediated cartilage formation. These studies indicate that BMP-initiated FGF-signaling induces a novel type of transcription...