..., we show in mouse neural stem and progenitor cells (NPCs) that TAZ regulates astrocytic differentiation and maturation, and that TAZ mediates some, but not all, of the effects of bone morphogenetic protein (BMP) signaling on astrocytic development. By contrast, both TAZ and YAP mediate the effects...

... to different TGF-β family ligands reveals distinct signalling dynamics driven by receptor localisation, which may underlie their biological function. TGF-β BMP Activin Signalling dynamics SMAD6/7 Receptor trafficking Cancer Research UK 10.13039/501100000289 FC001095 Medical...

.... Functionally, timp null mutants exhibit compromised synaptic vesicle cycling, with activity that is lower in amplitude and fidelity. NMJ defects manifest in impaired locomotor function. Mechanistically, we find that Timp limits BMP trans -synaptic signaling and the downstream synapse-to-nucleus signal...

... expression is triggered when Gliotactin is overexpressed, leading to activation of the BMP signalling pathway. Gliotactin specifically interferes with Dad, an inhibitory SMAD, leading to activation of the Tkv type-I receptor and activation of Mad to elevate the biogenesis and expression of miR-184...

...Andreas Benn; Clara Bredow; Isabel Casanova; Slobodan Vukičević; Petra Knaus ABSTRACT Several vascular disorders, such as aberrant angiogenesis, atherosclerosis and pulmonary hypertension, have been linked to dysfunctional BMP signaling. Vascular hyperpermeability via distortion of endothelial cell...

...Jonathan W. Lowery; Giuseppe Intini; Laura Gamer; Sutada Lotinun; Valerie S. Salazar; Satoshi Ote; Karen Cox; Roland Baron; Vicki Rosen ABSTRACT Imbalances in the ratio of bone morphogenetic protein (BMP) versus activin and TGFβ signaling are increasingly associated with human diseases yet...

... reduced cranial cartilages. Genetic data link these phenotypes to insulin-like growth factor (Igf)-binding protein-3 (Igfbp-3) and bone morphogenetic protein (Bmp) signaling, and biochemical analysis show specific Igfbp-3 proteolysis by Papp-a2, implicating Papp-a2 in the modulation of Bmp signaling...

...Valerie S. Salazar; Nicholas Zarkadis; Lisa Huang; Jin Norris; Susan K. Grimston; Gabriel Mbalaviele; Roberto Civitelli Summary To examine interactions between bone morphogenic protein (BMP) and canonical Wnt signaling during skeletal growth, we ablated Smad4 , a key component of the TGF-β–BMP...

... and regulating the output of various signaling pathways. Although Jab1 can interact with the bone morphogenetic protein (BMP) downstream effector Smad5 to repress BMP signaling in vitro , the role of Jab1 in BMP-mediated skeletogenesis in vivo is still poorly understood. As a key regulator of skeletogenesis, BMP...

... is regulated. Activation of the Bone Morphogenetic Protein (BMP) pathway at the Drosophila larval neuromuscular junction results in nuclear accumulation of the phosphorylated form of the transcription factor Mad in the motoneuron nucleus. This in turn regulates transcription of genes that control synaptic...

...Mohammed I. Ahmed; Andrei N. Mardaryev; Christopher J. Lewis; Andrey A. Sharov; Natalia V. Botchkareva Bone morphogenetic proteins (BMPs) play essential roles in the control of skin development, postnatal tissue remodelling and tumorigenesis. To explore whether some of the effects of BMP signalling...

... proliferating cultures can overcome this block, enabling continuous propagation of undifferentiated rat NS cells. We found that dormancy is induced by autocrine production of bone morphogenetic proteins (BMPs). Accordingly, the BMP antagonist noggin can replace conditioned medium to sustain continuous self...

... mice and regulates osteoblast differentiation through the β-catenin–BMP2/4– Osx signaling pathway in osteoblasts. The synergistic effect between β-catenin and bone morphogenetic protein (BMP) signaling in bone cells has been reported ( Fischer et al., 2002 ; Mbalaviele et al., 2005 ; Nakashima...

...Cristina Gamell; Nelson Osses; Ramon Bartrons; Thomas Rückle; Montserrat Camps; José Luis Rosa; Francesc Ventura Bone morphogenetic proteins (BMPs) are potent regulators of several cellular events. We report that exposure of C2C12 cells to BMP2 leads to an increase in cell migration and a rapid...

... progressively, offering new perspectives on their function and mechanism of action in both development and disease. These studies indicate that SFRPs are not merely Wnt-binding proteins, but can also antagonise one another's activity, bind to Fz receptors and influence axon guidance, interfere with BMP...

..., a bHLH transcription factor, suppresses bone morphogenetic protein (BMP)-induced osteoblast differentiation, and downregulation of endogenous Twist-1 enhances BMP signaling. Maximal inhibition of BMP signaling was observed when Twist-1 was bound to E47, which markedly enhanced the stability of Twist-1...

... signaling by recruiting and presenting Smad2/3 to the receptor complex. SARA does not bind Smad1 and hence does not enhance bone morphogenetic protein (BMP) signaling. Here we report for the first time that the endosome-associated FYVE-domain protein endofin acts as a Smad anchor for receptor activation...

...-receptor endoglin play an important role in vascular development and angiogenesis. Here, we demonstrate that ALK1 is a signalling receptor for bone morphogenetic protein-9 (BMP-9) in endothelial cells (ECs). BMP-9 bound with high affinity to ALK1 and endoglin, and weakly to the type-I receptor ALK2...

... kinase, G-protein-coupled or cytokine receptors. * Author for correspondence (e-mail: [email protected] ) © The Company of Biologists Limited 2005 2005 BMP MAPK PI3K Phosphatase Ras Rho Smad TGF-β The transforming growth factor β (TGF-β) superfamily encompasses...

... collagen, with a surface cell layer expressing type I collagen. In contrast, noggin inhibited both the TGFβ- and TGFβ+PDGF-stimulated cartilage formation, suggesting that a BMP-dependent pathway is involved. In fact, replacement of TGFβ3 with BMP4 on days 10 to 12 markedly elevated the cartilage matrix...