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Keywords: BDNF
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Journal Articles
J Cell Sci (2021) 134 (16): jcs258419.
Published: 20 August 2021
... investigated (i) the signaling competence of mouse embryonic and postnatal primary cortical astrocytes exposed to brain-derived neurotrophic factor (BDNF) and, (ii) the role of kinase D-interacting substrate of 220 kDa (Kidins220), a transmembrane scaffold protein that mediates neurotrophin signaling...
Includes: Supplementary data
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Proteostasis
J Cell Sci (2020) 133 (24): jcs247841.
Published: 23 December 2020
... (also known as NTRK2), a RTK, is ubiquitylated upon activation by brain-derived neurotrophic factor (BDNF) binding. Although TrkB ubiquitylation has been demonstrated, there is a lack of knowledge regarding the precise repertoire of proteins that regulates TrkB ubiquitylation. Here, we provide...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (9): jcs236943.
Published: 11 May 2020
... newly identified a mild mutation, Pex26-F51L that causes only hearing loss. We will also discuss findings from a new PBD model mouse defective in Pex14, which manifested dysregulation of the BDNF–TrkB pathway, an essential signaling pathway in cerebellar morphogenesis. Here, we thus aim to provide...
Journal Articles
J Cell Sci (2016) 129 (7): 1378–1390.
Published: 1 April 2016
...Robert Eckenstaler; Volkmar Lessmann; Tanja Brigadski ABSTRACT The secretory protein brain-derived neurotrophic factor (BDNF) is assumed to be a key factor for the induction of synaptic plasticity processes in neurons. However, the molecular mechanisms for activity-dependent release of the protein...
Includes: Supplementary data
Journal Articles
Journal Articles
J Cell Sci (2015) 128 (6): 1108–1122.
Published: 15 March 2015
...Wen-Hai Sui; Shu-Hong Huang; Jue Wang; Qun Chen; Ting Liu; Zhe-Yu Chen ABSTRACT Brain-derived neurotrophic factor (BDNF) plays an important role in neuronal survival, neurite outgrowth and synaptic plasticity by activating the receptor tropomyosin receptor kinase B (TrkB, also known as NTRK2). TrkB...
Includes: Supplementary data
Journal Articles
Journal Articles
J Cell Sci (2010) 123 (13): 2299–2307.
Published: 1 July 2010
... events. Previous studies have shown that occupancy of p75NTR by NGF or BDNF induced regulated intracellular proteolysis of the receptor, and that MAG binding to NgR1 resulted in p75NTR cleavage ( Domeniconi et al., 2005 ; Kenchappa et al., 2006 ; Urra et al., 2007 ). We directly compared NGF, BDNF...
Includes: Supplementary data
Journal Articles
J Cell Sci (2004) 117 (24): 5803–5814.
Published: 15 November 2004
.... The neurotrophin BDNF and its cognate receptor tyrosine kinase, TrkB.FL, are highly expressed in neurons of the central nervous system. At later stages in postnatal development the truncated TrkB splice variants (TrkB.T1, TrkB.T2) become abundant. However, the signalling and function of these truncated receptors...
Includes: Supplementary data
Journal Articles
J Cell Sci (2003) 116 (7): 1209–1217.
Published: 1 April 2003
... and cultures stimulated with brain-derived neurotrophic factor (BDNF), PPV clusters persisted in growth cones with a half-life( t 1/2 ) of >14 minutes. Upon challenge with IGF-1,however, fluorescent elements cleared from the growth cones with a t 1/2 of only 6 minutes. Plasmalemmal expansion was measured...
Journal Articles