..., as well as transducing signaling cascades. Consequently, ciliary dysfunction results in a broad range of phenotypes: the ciliopathies. Bardet–Biedl syndrome (BBS), a model ciliopathy, is caused by mutations in 16 known genes. However, the biochemical functions of the BBS proteins are not fully understood...

... with Bardet-Biedl syndrome (BBS) and Meckel-Gruber syndrome. We show that the BBSome is absent from organisms that produce cilia only for motility, predicting a dominant and ancient role for this complex in sensory function. We also show that the unusual centriole of Caenorhabditis elegans is highly divergent...

... Neuron Acetylation BBS HDAC6 Mammalian NIMA (never in mitosis A)-related kinases (Nek1-Nek11) are a family of Ser-Thr kinases that constitute approximately 2% of the entire human kinome ( Fry and Nigg, 1995 ; O'Connell et al., 2003 ; O'Regan et al., 2007 ; Quarmby and Mahjoub, 2005...