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Keywords: Axoneme
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Journal Articles
In collection:
Cilia and Flagella
Series: SUBJECT COLLECTION: CILIA AND FLAGELLA
J Cell Sci (2021) 134 (15): jcs258626.
Published: 03 August 2021
...Stephen M. King ABSTRACT Axonemal dyneins power the beating of motile cilia and flagella. These massive multimeric motor complexes are assembled in the cytoplasm, and subsequently trafficked to cilia and incorporated into the axonemal superstructure. Numerous cytoplasmic factors are required...
Journal Articles
In collection:
Cilia and Flagella
J Cell Sci (2020) 133 (17): jcs249805.
Published: 11 September 2020
...Julie Craft Van De Weghe; J. Aaron Harris; Tomohiro Kubo; George B. Witman; Karl F. Lechtreck ABSTRACT Tubulin enters the cilium by diffusion and motor-based intraflagellar transport (IFT). However, the respective contribution of each route in providing tubulin for axonemal assembly remains unknown...
Includes: Supplementary data
Journal Articles
In collection:
Cytoskeleton
J Cell Sci (2019) 132 (3): jcs226951.
Published: 07 February 2019
..., it is most prominent on the axonemes of cilia and flagella. Not surprisingly, most functional insight has so far been gained on its role to control the functions of these organelles (reviewed in Magiera et al., 2018b ). Nevertheless, the broad occurrence of polyglutamylation, and the presence of multiple...
Includes: Supplementary data
Journal Articles
In collection:
Cilia and Flagella
J Cell Sci (2018) 131 (19): jcs221648.
Published: 11 October 2018
...Ferheen Abbasi; Haruhiko Miyata; Keisuke Shimada; Akane Morohoshi; Kaori Nozawa; Takafumi Matsumura; Zoulan Xu; Putri Pratiwi; Masahito Ikawa ABSTRACT The flagellum is an evolutionarily conserved appendage used for sensing and locomotion. Its backbone is the axoneme and a component of the axoneme...
Includes: Supplementary data
Journal Articles
In collection:
Cilia and Flagella
J Cell Sci (2018) 131 (9): jcs212324.
Published: 04 May 2018
... is necessary for the interaction of ARL13B with the axoneme both in vitro and in vivo . We further show that exogenously expressed mutants lacking the tubulin-binding G-domain (ARL13B-ΔGD) or whose GTPase domain is inactivated (ARL13B-T35N) retain ciliary localization, but fail to rescue ciliogenesis defects...
Includes: Supplementary data
Journal Articles
J Cell Sci (2016) 129 (14): 2757–2766.
Published: 15 July 2016
...Alu Konno; Koji Ikegami; Yoshiyuki Konishi; Hyun-Jeong Yang; Manabu Abe; Maya Yamazaki; Kenji Sakimura; Ikuko Yao; Kogiku Shiba; Kazuo Inaba; Mitsutoshi Setou ABSTRACT Nine outer doublet microtubules in axonemes of flagella and cilia are heterogeneous in structure and biochemical properties...
Includes: Supplementary data
Journal Articles
J Cell Sci (2016) 129 (8): 1547–1551.
Published: 15 April 2016
...Toshiyuki Oda; Tatsuki Abe; Haruaki Yanagisawa; Masahide Kikkawa ABSTRACT The docking complex is a molecular complex necessary for assembly of outer dynein arms (ODAs) on the axonemal doublet microtubules (DMTs) in cilia and flagella. The docking complex is hypothesized to be a 24-nm molecular...
Includes: Supplementary data
Journal Articles
In collection:
Cilia and Flagella
J Cell Sci (2016) 129 (5): 943–956.
Published: 01 March 2016
...Dhivya Kumar; Crysten E. Blaby-Haas; Sabeeha S. Merchant; Richard E. Mains; Stephen M. King; Betty A. Eipper ABSTRACT Ciliary axonemes and basal bodies were present in the last eukaryotic common ancestor and play crucial roles in sensing and responding to environmental cues. Peptidergic signaling...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (7): 1294–1307.
Published: 01 April 2015
... and stabilization as well as being necessary for ciliary localization. Finally, overexpression and knockdown studies show that hSAXO1 modulates axoneme length. Taken together, our findings suggest a fine regulation of hSAXO1 localization and important roles in cilium biogenesis and function. * Author...
Includes: Supplementary data
Journal Articles
J Cell Sci (2013) 126 (24): 5748–5757.
Published: 15 December 2013
... distributed under the terms of the Creative Commons Attribution License ( http://creativecommons.org/licenses/by/3.0/ ), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed. Trypanosoma brucei Flagellum Axoneme Serial...
Includes: Supplementary data
Journal Articles
J Cell Sci (2010) 123 (4): 519–528.
Published: 15 February 2010
...Charles B. Lindemann; Kathleen A. Lesich The working mechanism of the eukaryotic flagellar axoneme remains one of nature's most enduring puzzles. The basic mechanical operation of the axoneme is now a story that is fairly complete; however, the mechanism for coordinating the action of the dynein...
Journal Articles
J Cell Sci (2008) 121 (7): 1076–1084.
Published: 01 April 2008
...Ho-Chun Wei; Janet Rollins; Lacramioara Fabian; Madeline Hayes; Gordon Polevoy; Christopher Bazinet; Julie A. Brill Axonemes are microtubule-based organelles of crucial importance in the structure and function of eukaryotic cilia and flagella. Despite great progress in understanding how axonemes...
Includes: Supplementary data
Journal Articles
J Cell Sci (2006) 119 (16): 3443–3455.
Published: 15 August 2006
...Carole Branche; Linda Kohl; Géraldine Toutirais; Johanna Buisson; Jacky Cosson; Philippe Bastin The Trypanosoma brucei flagellum is unusual as it is attached along the cell body and contains, in addition to an apparently conventional axoneme, a structure called the paraflagellar rod, which...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2006) 119 (12): 2405–2413.
Published: 15 June 2006
...C. Gadelha; B. Wickstead; P. G. McKean; K. Gull Productive beating of eukaryotic flagella and cilia requires a strict regulation of axonemal dynein activation. Fundamental to any description of axonemal beating is an understanding of the significance of the central pair microtubules and the degree...
Journal Articles
J Cell Sci (2006) 119 (6): 1165–1174.
Published: 15 March 2006
... apparent homologs in humans, indicating that the radial spoke has been conserved throughout evolution. The human genes encoding these proteins are candidates for causing primary ciliary dyskinesia, a severe inherited disease involving missing or defective axonemal structures, including the radial spokes...
Includes: Supplementary data
Journal Articles
J Cell Sci (2005) 118 (23): 5421–5430.
Published: 01 December 2005
...Helen R. Dawe; Helen Farr; Neil Portman; Michael K. Shaw; Keith Gull Eukaryotic cilia and flagella are highly conserved structures composed of a canonical 9+2 microtubule axoneme. Comparative genomics of flagellated and non-flagellated eukaryotes provides one way to identify new putative flagellar...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2005) 118 (20): 4655–4665.
Published: 15 October 2005
... projection, we took an immunoprecipitation approach using antibodies generated against PF6. The pf6 mutant lacks the C1a projection and possesses flagella that only twitch; calcium-induced modulation of dynein activity on specific doublet microtubules is also defective in pf6 axonemes. Our antibodies...
Includes: Supplementary data
Journal Articles
J Cell Sci (2005) 118 (15): 3317–3326.
Published: 01 August 2005
...-related kinase, Cnk2p, is an axonemal protein that affects flagellar length via effects on disassembly rate and also plays a role in the cellular assessment of size prior to committing to mitosis. This is the second NIMA-related kinase shown to affect ciliary function and cell cycle progression...
Journal Articles
J Cell Sci (2003) 116 (20): 4181–4190.
Published: 15 October 2003
... functions, including neuronal differentiation, axonemal beating and stability of the centrioles, and shown to modulate the interaction between tubulin and microtubule associated proteins. The enzymes catalysing this modification are not yet known. Starting with a partially purified fraction of mouse brain...
Includes: Supplementary data