... contact sites. SNARE Axonal growth Filopodia Lipid transfer protein Membrane contact site Membrane trafficking Association Française contre les Myopathies 10.13039/100013465 16612 Agence Nationale de la Recherche 10.13039/501100001665 ANR-13-BSV2-0018-02 ANR-16-CE16...

... Cdk5 p25 p35 β-Amyloid Excitotoxicity Cdk Cyclins Neurodegeneration Alzheimer’s disease Synaptic plasticity Learning and memory Pain signalling Neuronal migration Axonal growth Synaptogenesis Cyclin-dependent kinases (Cdks) are Ser/Thr protein kinases that associate with specific...

... and describe, for the first time, their subcellular functions during axonal growth. Firstly, both ACF7 and Shot regulate the organisation of neuronal microtubules, a role dependent on both the F-actin- and microtubule-binding domains. This role in microtubule organisation is probably the key mechanism...

... stimuli. Because recent reports show that Ca 2+ transients in growth cones negatively regulate axonal growth, we studied how ionotropic ATP receptors (P2X) might participate in this process. Our results show that exposing cultured hippocampal neurons to ATP induces Ca 2+ transients in the distal domain...

... the length, composition and charge distribution of the polysaccharide chain. Using cultured primary neurons, we show that specific sulfation in the GAG chains of chondroitin sulfate mediates neuronal guidance cues and axonal growth inhibition. Chondroitin-4-sulfate (CS-A), but not chondroitin-6-sulfate (CS-C...

... organisms. Here we demonstrate that co-stimulation of dorsal root ganglion neurons with neurotrophic factors (NTFs) – glial-cell-line-derived neurotrophic factor, neurturin or nerve growth factor – and laminin leads to axonal growth that requires activation of Src family kinases (SFKs). A different, SFK...

... at the growth cone. This report examines whether this is a regulated event controlled by growth factors. The Golgi complex and nascent PPVs of hippocampal neurons in culture were pulse-labeled with fluorescent ceramide. We studied the dynamics of labeled PPVs upon arrival at the axonal growth cone. In controls...

...Michael Schmalfeldt; Christine E. Bandtlow; María T. Dours-Zimmermann; Kaspar H. Winterhalter; Dieter R. Zimmermann ABSTRACT In this paper, we identify the chondroitin sulfate proteoglycan versican V2 as a major inhibitor of axonal growth in the extracellular matrix of the mature central nervous...

... Cytomechanics Axonal growth Brain development Axonal development by peripheral neurons has been shown to be intimately dependent on mechanical tension. Axons of chick sensory neurons and PC12 cells can be experimentally initiated by applying tension to the margin of the cell body ( Bray, 1984 ; Zheng...

... act as an inhibitory cue for axonal growth and that arachidonic acid is the second messenger responsible for this activity. We discuss the possibility that arachidonic acid inhibits neurite outgrowth by desensitising the second messenger pathway underlying neuronal responsiveness to cell adhesion...

... University School of Medicine, 333 Cedar Street, New Haven, CT, USA 19 07 1993 27 09 1993 © 1994 by Company of Biologists 1994 neuronal growth cone GAP-43 (neuromodulin) GTP-binding protein signal transduction cell spreading axonal growth As a growth cone during...

..., for example, by the differential expression of laminin variants. © The Company of Biologists Limited 1991 1991 laminin gene expression basement membrane nervous system axonal growth Neuronal survival and differentiation in both the developing peripheral and central nervous systems depend...