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Keywords: Axon degeneration
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Journal Articles
J Cell Sci (2023) 136 (18): jcs261557.
Published: 20 September 2023
... and DRG neurons in microfluidic chambers and induce robust myelination. Cocultures can be axotomised to study injury and used for drug treatments, and cells can be lentivirally transduced for live imaging. We used this model to investigate axon degeneration after traumatic axotomy and find that SCs...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (6): 1241–1252.
Published: 15 March 2015
..., respectively. In all live-imaging assays performed, imaging of myotube contractions, Fluo-3 transients, FM dye, axonal degeneration after H 2 O 2 and axonal transport, living samples were maintained in a humidified incubation chamber at 37°C, 5% CO 2 . Details of fluorescent labels and excitation and emission...
Includes: Supplementary data
Journal Articles
J Cell Sci (2013) 126 (3): 838–849.
Published: 1 February 2013
...Andrew Rallis; Bingwei Lu; Julian Ng Summary Axon degeneration is observed at the early stages of many neurodegenerative conditions and this often leads to subsequent neuronal loss. We previously showed that inactivating the c-Jun N-terminal kinase (JNK) pathway leads to axon degeneration...
Includes: Supplementary data