... and DRG neurons in microfluidic chambers and induce robust myelination. Cocultures can be axotomised to study injury and used for drug treatments, and cells can be lentivirally transduced for live imaging. We used this model to investigate axon degeneration after traumatic axotomy and find that SCs...

... the fraction of healthy, blebbing and fragmented axons after application of 1 mM H 2 O 2 in (A) the neuronal/proximal or (B) muscle/distal compartment. (C,D) Timecourse images of HB9::GFP (green) axon degeneration. Images were taken with an epifluorescent microscope with a 10× objective. Arrowheads denote...

...Andrew Rallis; Bingwei Lu; Julian Ng Summary Axon degeneration is observed at the early stages of many neurodegenerative conditions and this often leads to subsequent neuronal loss. We previously showed that inactivating the c-Jun N-terminal kinase (JNK) pathway leads to axon degeneration...