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Keywords: Axin
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Journal Articles
J Cell Sci (2015) 128 (1): 33–39.
Published: 1 January 2015
...Dominic B. Bernkopf; Michel V. Hadjihannas; Jürgen Behrens ABSTRACT Axin and conductin (also known as axin2) are structurally related inhibitors of Wnt/β-catenin signalling that promote degradation of β-catenin. Whereas axin is constitutively expressed, conductin is a Wnt target gene implicated...
Includes: Supplementary data
Journal Articles
J Cell Sci (2008) 121 (11): 1793–1802.
Published: 1 June 2008
... of the destruction complex – APC and axin – and the activated Wnt co-receptor LRP6. β-catenin induced through the Wnt receptor complex was significantly more competent transcriptionally than overexpressed β-catenin, both in cultured cells and in early Xenopus embryos. Our data reveal a new step in the processing...
Includes: Supplementary data
Journal Articles
J Cell Sci (2007) 120 (14): 2402–2412.
Published: 15 July 2007
... receptors, and also to axin to block its activity, which results in the activation of β-catenin and, consequently, in a transcriptional switch. We have previously reported that the DIX domain of mammalian Dvl2 allows it to form dynamic protein assemblies. Here, we show that these Dvl2 assemblies recruit...
Journal Articles
J Cell Sci (2005) 118 (22): 5269–5277.
Published: 15 November 2005
... exchange of GFP-Dvl2 between puncta and a diffuse cytoplasmic pool, which, therefore, are in a dynamic equilibrium with each other. The same is true for the DIX domain of Dvl2 itself and also for Axin-GFP, which equilibrates between the punctate and cytosolic pools. Our evidence indicates that Dvl2...
Includes: Multimedia, Supplementary data