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Keywords: Auxin-inducible degron
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Journal Articles
J Cell Sci (2023) 136 (8): jcs260754.
Published: 19 April 2023
... a pair of switches that were independently controlled by both inducible promoters and degrons, enabling the toggling between two constructs with comparable kinetics and tightness. The gene-OFF switch was based on TRE transcriptional control coupled with auxin-induced degron-mediated proteolysis. A second...
Includes: Supplementary data
Journal Articles
J Cell Sci (2019) 132 (2): jcs223123.
Published: 25 January 2019
... established near-diploid HCT116 cell lines containing endogenous Chk1 protein tagged with a minimum auxin-inducible degron (mAID) through CRISPR/Cas9-based gene editing. Establishment of these cells enabled us to induce specific and rapid depletion of the endogenous Chk1 protein, which resulted in aberrant...
Includes: Supplementary data
Journal Articles
J Cell Sci (2018) 131 (6): jcs212092.
Published: 22 March 2018
... of mitotic chromosomes, had also been shown to make a contribution to the process. To examine their respective roles, we generated a set of HCT116-based cell lines expressing Ki-67 and/or condensin subunits that were fused with an auxin-inducible degron for their conditional degradation. Both...
Includes: Supplementary data