...Carmen Figueras-Novoa; Lewis Timimi; Elena Marcassa; Rachel Ulferts; Rupert Beale ABSTRACT Autophagy refers to a set of degradative mechanisms whereby cytoplasmic contents are targeted to the lysosome. This is best described for macroautophagy, where a double-membrane compartment (autophagosome...

.... For example, LINC complex proteins interact with both chromatin and the cytoskeleton. Here, we report that the Drosophila Nesprin MSP300 has an additional function in autophagy within larval body wall muscles. RNAi-mediated MSP300 knockdown in larval body wall muscles resulted in defects in the contractile...

... and govern microbial fate. Streptococcus pneumoniae Pneumolysin Pore formation Galectin Autophagy First-passage process Science and Engineering Research Board http://dx.doi.org/10.13039/501100001843 MTR/2019/000341 SPR/2019/000808 Indian Institute of Technology Bombay...

... pluripotency. In addition to alterations in the gene expression profile, cellular reprogramming requires rearrangement of the proteome, organelles and metabolism, but these changes are comparatively less studied. In this context, autophagy, a cellular catabolic process that participates in the recycling...

...Alexander R. van Vliet; Harold B. J. Jefferies; Peter A. Faull; Jessica Chadwick; Fairouz Ibrahim; Mark J. Skehel; Sharon A. Tooze ABSTRACT ATG9A, a transmembrane protein of the core autophagy pathway, cycles between the Golgi, endosomes and a vesicular compartment. ATG9A was recently shown to act...

...Akshaya Nambiar; Ravi Manjithaya ABSTRACT Most of the vesicular transport pathways inside the cell are facilitated by molecular motors that move along cytoskeletal networks. Autophagy is a well-explored catabolic pathway that is initiated by the formation of an isolation membrane known...

... Pancreatic ductal adenocarcinoma (PDAC) exhibits elevated levels of autophagy, which promote tumor progression and treatment resistance. ATG4B is an autophagy-related cysteine protease under consideration as a potential therapeutic target, but it is largely unexplored in PDAC. Here, we investigated...

...Jose L. Nieto-Torres; Sviatlana Zaretski; Tianhui Liu; Peter D. Adams; Malene Hansen ABSTRACT Autophagy is a recycling mechanism involved in cellular homeostasis with key implications for health and disease. The conjugation of the ATG8 family proteins, which includes LC3B (also known as MAP1LC3B...

... of histones. In recent decades, proteomic analyses have revealed that p300 is also involved in the regulation of various cellular processes by acetylating many non-histone proteins. Among the identified substrates, some are key players involved in different autophagy steps, which together establish p300...

... preserving neuronal energy homeostasis. Here, we review the contribution of mitophagy, a selective form of autophagy that targets dysfunctional or superfluous mitochondria for degradation, in maintaining nervous system homeostasis. In addition, we discuss recent evidence implicating defective or dysregulated...

...Bernd Bauer; Sascha Martens; Luca Ferrari ABSTRACT Cells keep their proteome functional by the action of the proteostasis network, composed of the chaperones, the ubiquitin-proteasome system and autophagy. The decline of this network results in the accumulation of protein aggregates...

... of Biologists Ltd 2023 Summary: Key recent advances in our understanding of crinophagy – the direct fusion of secretory granules with lysosomes – and related degradation pathways are discussed, including potential links to disease. Autophagy Crinophagy Secretion National Research...

...-autonomous immune responses including antibacterial autophagy and septin cage entrapment. How septins interact with the autophagy process to target Shigella for destruction is poorly understood. Here, we employed a correlative light and cryo-soft X-ray tomography (cryo-SXT) pipeline to study Shigella septin...

... for Vps1 accumulation and activity on peroxisomes. Dynamin-related protein Peroxisome Autophagy Drp1 University of Sheffield http://dx.doi.org/10.13039/501100000858 Saudi Arabia Cultural Bureau in London http://dx.doi.org/10.13039/100012363 University of Bisha...

...Pablo Sánchez-Martín; Franziska Kriegenburg; Ludovico Alves; Julius Adam; Jana Elsaesser; Riccardo Babic; Hector Mancilla; Mariya Licheva; Georg Tascher; Christian Münch; Stefan Eimer; Claudine Kraft ABSTRACT Autophagy is a catabolic process during which cytosolic material is enwrapped in a newly...

... that the original work is properly attributed. Summary: Mammalian cells form nuclear buds and micronuclei containing autophagy proteins in a basal way and in response to DNA double strand breaks, suggesting homeostatic nuclear maintenance by nucleophagy. Mammalian nucleophagy Autophagy DNA damage...

... kinase Proteasome storage granules Proteaphagy Mitochondrial inhibition Autophagy National Institutes of Health http://dx.doi.org/10.13039/100000002 P20GM103418 R01GM118660 National Institute of General Medical Sciences http://dx.doi.org/10.13039/100000057...

..., suppression of autophagy by 3-methyladenine (3-MA) treatment compromised the effect of metformin on DNA damage. In vivo studies also showed that 3-MA might diminish the therapeutic effect of metformin on IVDD. Taken together, our results reveal that metformin may suppress senescence via inactivating the cGAS...

.... Appressoria are specialised infection cells that facilitate host cell invasion. Appressorium Plant pathogen Autophagy Cell cycle control Effector Host–pathogen interface Melanin biosynthesis Septin Gatsby Charitable Foundation http://dx.doi.org/10.13039/501100000324 Halpin...

...Eugenia Almacellas; Caroline Mauvezin ABSTRACT Lysosomes exert pleiotropic functions to maintain cellular homeostasis and degrade autophagy cargo. Despite the great advances that have boosted our understanding of autophagy and lysosomes in both physiology and pathology, their function in mitosis...