... peptide, whereas P-factor is a simple peptide. To examine whether this chemical asymmetry in the two pheromones is essential for conjugation, we constructed a mating system in which either pheromone can stimulate both M- and P-cells, and examined whether the resulting autocrine strains can mate. Autocrine...

... survival, proliferation and motility. A schematic model representing the putative RANK–RANKL signaling interactions pertaining to osteosarcoma cells and mammary epithelial cells. In osteosarcoma, RANK signaling is facilitated through paracrine, autocrine and homotypic mechanisms where Erk1/2 plays...

...Ann E. DeWitt; Jian Ying Dong; H. Steven Wiley; Douglas A. Lauffenburger Autocrine signaling is important in normal tissue physiology as well as pathological conditions. It is difficult to analyze these systems, however, because they are both self-contained and recursive. To understand how...