.... Muscle Autolysosome Drosophila Metamorphosis Atrophy Syntaxin17 Lysosomes are membrane-bound compartments for the degradation of both endocytic and autophagic cargoes in the eukaryotic cell. The lumen of lysosomes maintains an acidic pH to allow digestion of materials by a series of acid...

... proteins like several different myosin heavy chain proteins (MyHC) to proteasomal degradation during muscle atrophy. In two unbiased screens, we identified DCAF8 as a new MuRF1-binding partner. MuRF1 physically interacts with DCAF8 and both proteins localize to overlapping structures in muscle cells...

... architecture and neuromuscular junctions. Atm -knockout mice showed reduced muscle and fiber size. Atrophy, protein synthesis impairment and a switch from glycolytic to oxidative fibers were detected, along with an increase of in expression of slow and fast myosin types ( Myh7 , and Myh2 and Myh4...

...Laura Collard; Gaëlle Herledan; Alessandra Pincini; Aline Guerci; Voahangy Randrianarison-Huetz; Athanassia Sotiropoulos ABSTRACT Skeletal muscle atrophy is a debilitating process that is associated with a wide variety of conditions including inactivity, disease and aging. Here, we demonstrate...