... and atherosclerosis . Circ. Res. 119 , 450 - 462 . 10.1161/CIRCRESAHA.116.308870 Mahmoud , M. M. , Serbanovic-Canic , J. , Feng , S. , Souilhol , C. , Xing , R. , Hsiao , S. , Mammoto , A. , Chen , J. , Ariaans , M. , Francis , S. E. et al. ( 2017 ). Shear...

...Luya Pu; Qingyu Meng; Shuai Li; Yaru Wang; Banghao Sun; Bin Liu; Fan Li ABSTRACT Laminar shear stress (Lss) is an important anti-atherosclerosis (anti-AS) factor, but its mechanism network is not clear. Therefore, this study aimed to identify how Lss acts against AS formation from a new perspective...

... affects VSMC proliferation and migration, impacting atherosclerosis. In summary, this work shows that ChA is sufficient to induce lysosomal dysfunction in VSMCs, that, in ChA-treated VSMCs, neither lysosome biogenesis nor autophagy are triggered, and, finally, that recombinant LAL can be a therapeutic...

... ). Diabetes and atherosclerosis: epidemiology, pathophysiology, and management . JAMA 287 , 2570 - 2581 . 10.1001/jama.287.19.2570 Böttcher , R. T. , Wiesner , S. , Braun , A. , Wimmer , R. , Berna , A. , Elad , N. , Medalia , O. , Pfeifer , A. , Aszódi...

...Rajesh K. Singh; Frederik W. Lund; Abigail S. Haka; Frederick R. Maxfield ABSTRACT Low-density lipoprotein (LDL) deposition, aggregation and retention in the endothelial sub-intima are critical initiating events during atherosclerosis. Macrophages digest aggregated LDL (agLDL) through a process...

..., but it is not activated by bidirectional force. Shear stress β1 integrin Blood flow Endothelial cell Atherosclerosis Mechanoreceptor Author contributions Conceptualization: P.C.E., I.X., C.S., J.S.-C., A.C.K., M.F., N.A., V.R., J.W., E.P., M.J.H., M.T.B.; Validation: P.C.E., I.X., C.S., J.S.-C...

...Arif Yurdagul, Jr; Florian J. Sulzmaier; Xiao L. Chen; Christopher B. Pattillo; David D. Schlaepfer; A. Wayne Orr ABSTRACT Oxidized low-density lipoprotein (oxLDL) accumulates early in atherosclerosis and promotes endothelial nuclear factor κB (NF-κB) activation, proinflammatory gene expression...

... feedback regulation between let-7g and LOX-1, and indicate that let-7g could be a target to treat cardiovascular disease. Atherosclerosis is a chronic inflammatory disease characterized by lipid-rich plaques within arterial walls ( Libby, 2002 ). The accumulation of oxidized low-density lipoprotein...

... and cellular responses (Smad2 phosphorylation/nuclear localization and expression of PAI-1). Dynasore, a newly identified inhibitor of dynamin GTPase activity, is one of the most potent inhibitors among those tested and, furthermore, is a potent enhancer of TGFβ. Dynasore ameliorates atherosclerosis...

... network abrogated all the observed effects, suggesting that cholesterol affects the mechanical properties of a cell through the underlying cytoskeleton. The results of these quantitative studies may help to better understand the biomechanical processes accompanying the development of atherosclerosis...

... microbial and human HSP act as dominant antigens in numerous infectious and autoimmune diseases such as atherosclerosis, inducing a strong immune-inflammatory response. In the present study, the surface localization of HSP60 on stressed and unstressed human umbilical venous endothelial cells (HUVECs...

.... * Author for correspondence (e-mail: levye@justine.umontreal.ca ) 5 9 2003 © The Company of Biologists Limited 2004 2004 SR-BI Enterocyte Cholesterol transport Caveolin-1 Malabsorption Atherosclerosis The abnormalities of intestinal cholesterol transport can contribute...