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1-17 of 17
Keywords: Atherosclerosis
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Journal Articles
Matthew Rickman, Mean Ghim, Kuin Pang, Ana Cristina von Huelsen Rocha, Elena M. Drudi, Macià Sureda-Vives, Nicolas Ayoub, Virginia Tajadura-Ortega, Sarah J. George, Peter D. Weinberg, Christina M. Warboys
Journal:
Journal of Cell Science
J Cell Sci (2023) 136 (6): jcs260449.
Published: 24 March 2023
... and atherosclerosis . Circ. Res. 119 , 450 - 462 . 10.1161/CIRCRESAHA.116.308870 Mahmoud , M. M. , Serbanovic-Canic , J. , Feng , S. , Souilhol , C. , Xing , R. , Hsiao , S. , Mammoto , A. , Chen , J. , Ariaans , M. , Francis , S. E. et al. ( 2017 ). Shear...
Includes: Supplementary data
Journal Articles
Journal:
Journal of Cell Science
J Cell Sci (2022) 135 (14): jcs259696.
Published: 22 July 2022
...Luya Pu; Qingyu Meng; Shuai Li; Yaru Wang; Banghao Sun; Bin Liu; Fan Li ABSTRACT Laminar shear stress (Lss) is an important anti-atherosclerosis (anti-AS) factor, but its mechanism network is not clear. Therefore, this study aimed to identify how Lss acts against AS formation from a new perspective...
Includes: Supplementary data
Journal Articles
Liliana S. Alves, André R. A. Marques, Nuno Padrão, Filomena A. Carvalho, José Ramalho, Catarina S. Lopes, Maria I. L. Soares, Clare E. Futter, Teresa M. V. D. Pinho e Melo, Nuno C. Santos, Otília V. Vieira
Journal:
Journal of Cell Science
J Cell Sci (2022) 135 (5): jcs254631.
Published: 22 October 2021
... affects VSMC proliferation and migration, impacting atherosclerosis. In summary, this work shows that ChA is sufficient to induce lysosomal dysfunction in VSMCs, that, in ChA-treated VSMCs, neither lysosome biogenesis nor autophagy are triggered, and, finally, that recombinant LAL can be a therapeutic...
Includes: Supplementary data
Journal Articles
Journal:
Journal of Cell Science
J Cell Sci (2021) 134 (9): jcs249060.
Published: 7 May 2021
... ). Diabetes and atherosclerosis: epidemiology, pathophysiology, and management . JAMA 287 , 2570 - 2581 . 10.1001/jama.287.19.2570 Böttcher , R. T. , Wiesner , S. , Braun , A. , Wimmer , R. , Berna , A. , Elad , N. , Medalia , O. , Pfeifer , A. , Aszódi...
Journal Articles
In collection:
Cell biology and disease
Journal:
Journal of Cell Science
J Cell Sci (2019) 132 (23): jcs237271.
Published: 2 December 2019
...Rajesh K. Singh; Frederik W. Lund; Abigail S. Haka; Frederick R. Maxfield ABSTRACT Low-density lipoprotein (LDL) deposition, aggregation and retention in the endothelial sub-intima are critical initiating events during atherosclerosis. Macrophages digest aggregated LDL (agLDL) through a process...
Includes: Supplementary data
Journal Articles
Ioannis Xanthis, Celine Souilhol, Jovana Serbanovic-Canic, Hannah Roddie, Antreas C. Kalli, Maria Fragiadaki, Raymond Wong, Dhruv R. Shah, Janet A. Askari, Lindsay Canham, Nasreen Akhtar, Shuang Feng, Victoria Ridger, Jonathan Waltho, Emmanuel Pinteaux, Martin J. Humphries, Matthew T. Bryan, Paul C. Evans
Journal:
Journal of Cell Science
J Cell Sci (2019) 132 (11): jcs229542.
Published: 3 June 2019
... cell Atherosclerosis Mechanoreceptor British Heart Foundation 10.13039/501100000274 Kidney Research UK 10.13039/501100000291 Cancer Research UK 10.13039/501100000289 Although multiple mechanoreceptors have been identified, the fundamental mechanisms...
Includes: Supplementary data
Journal Articles
Arif Yurdagul, Jr, Florian J. Sulzmaier, Xiao L. Chen, Christopher B. Pattillo, David D. Schlaepfer, A. Wayne Orr
Journal:
Journal of Cell Science
J Cell Sci (2016) 129 (8): 1580–1591.
Published: 15 April 2016
...Arif Yurdagul, Jr; Florian J. Sulzmaier; Xiao L. Chen; Christopher B. Pattillo; David D. Schlaepfer; A. Wayne Orr ABSTRACT Oxidized low-density lipoprotein (oxLDL) accumulates early in atherosclerosis and promotes endothelial nuclear factor κB (NF-κB) activation, proinflammatory gene expression...
Includes: Supplementary data
Journal Articles
Ku-Chung Chen, I-Chung Hsieh, Edward Hsi, Yung-Song Wang, Chia-Yen Dai, Wen-Wen Chou, Suh-Hang Hank Juo
Journal:
Journal of Cell Science
J Cell Sci (2011) 124 (23): 4115–4124.
Published: 1 December 2011
... feedback regulation between let-7g and LOX-1, and indicate that let-7g could be a target to treat cardiovascular disease. Intracellular Ca 2+ was a well-known upstream regulator of PKC that participates in the development of atherosclerosis ( Velarde et al., 2001 ). Therefore, intracellular Ca 2+ might...
Includes: Supplementary data
Journal Articles
Journal:
Journal of Cell Science
J Cell Sci (2009) 122 (11): 1863–1871.
Published: 1 June 2009
... and cellular responses (Smad2 phosphorylation/nuclear localization and expression of PAI-1). Dynasore, a newly identified inhibitor of dynamin GTPase activity, is one of the most potent inhibitors among those tested and, furthermore, is a potent enhancer of TGFβ. Dynasore ameliorates atherosclerosis...
Includes: Supplementary data
Journal Articles
Mingzhai Sun, Nathan Northup, Francoise Marga, Tamas Huber, Fitzroy J. Byfield, Irena Levitan, Gabor Forgacs
Journal:
Journal of Cell Science
J Cell Sci (2007) 120 (13): 2223–2231.
Published: 1 July 2007
... network abrogated all the observed effects, suggesting that cholesterol affects the mechanical properties of a cell through the underlying cytoskeleton. The results of these quantitative studies may help to better understand the biomechanical processes accompanying the development of atherosclerosis...
Journal Articles
Gerald Pfister, Cordula M. Stroh, Hannes Perschinka, Michaela Kind, Michael Knoflach, Peter Hinterdorfer, Georg Wick
Journal:
Journal of Cell Science
J Cell Sci (2005) 118 (8): 1587–1594.
Published: 15 April 2005
... microbial and human HSP act as dominant antigens in numerous infectious and autoimmune diseases such as atherosclerosis, inducing a strong immune-inflammatory response. In the present study, the surface localization of HSP60 on stressed and unstressed human umbilical venous endothelial cells (HUVECs...
Includes: Multimedia, Supplementary data
Journal Articles
Emile Levy, Daniel Ménard, Isabelle Suc, Edgard Delvin, Valérie Marcil, Louise Brissette, Louise Thibault, Moise Bendayan
Journal:
Journal of Cell Science
J Cell Sci (2004) 117 (2): 327–337.
Published: 15 January 2004
..., and extends our knowledge in SR-BI-mediated cholesterol transport. * Author for correspondence (e-mail: [email protected] ) 5 9 2003 © The Company of Biologists Limited 2004 2004 SR-BI Enterocyte Cholesterol transport Caveolin-1 Malabsorption Atherosclerosis...
Journal Articles
Journal:
Journal of Cell Science
J Cell Sci (2001) 114 (7): 1273–1282.
Published: 1 April 2001
... immunofluorescence staining of native hLOX-1 and truncated mutants (green). (A2-E2) Binding of DiI-AcLDL (red) by native LOX-1 and truncated mutants. (A3-E3) Phase contrast examination of the images shown in A1-E1 and A2-E2. Scavenger receptor Site-directed mutagenesis Ligand binding Atherosclerosis...
Journal Articles
Journal:
Journal of Cell Science
J Cell Sci (2000) 113 (13): 2355–2361.
Published: 1 July 2000
... endothelium and to promote the formation of fatty streaks resembling early atherosclerosis in humans. * Author for correspondence (e-mail: [email protected] ) ‡ Present address: Dept of Medicine, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York, 10461, USA...
Journal Articles
Journal:
Journal of Cell Science
J Cell Sci (1998) 111 (19): 2977–2988.
Published: 10 January 1998
..., although the association between smooth muscle de-differentiation and atherosclerosis was first noted over 30 years ago, the molecular mechanisms controlling the extent of smooth muscle differentiation in vivo remain unclear. Of the three muscle types, significantly more experiments have been performed...
Journal Articles
Journal:
Journal of Cell Science
J Cell Sci (1995) 108 (1): 379–386.
Published: 1 January 1995
... the development of atherosclerosis. 24 06 1994 22 09 1994 © 1995 by Company of Biologists 1995 mitogen growth inhibitor macrophage smooth muscle dialysis culture atherosclerosis Accumulation of smooth muscle cells (SMC) in the arterial intima is found in the majority...
Journal Articles
Journal:
Journal of Cell Science
J Cell Sci (1993) 106 (4): 1301–1311.
Published: 1 December 1993
... by Company of Biologists 1993 macrophages mitogens inhibitors atherosclerosis In a majority of atherosclerotic lesions of clinical signifi-cance, the arterial intima is thickened by the accumulation of smooth muscle cells (SMC) that have migrated from the media to the intima, where...