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Keywords: Atherosclerosis
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Journal Articles
J Cell Sci (2022) 135 (5): jcs254631.
Published: 22 October 2021
... affects VSMC proliferation and migration, impacting atherosclerosis. In summary, this work shows that ChA is sufficient to induce lysosomal dysfunction in VSMCs, that, in ChA-treated VSMCs, neither lysosome biogenesis nor autophagy are triggered, and, finally, that recombinant LAL can be a therapeutic...
Includes: Supplementary data
Journal Articles
J Cell Sci (2021) 134 (9): jcs249060.
Published: 07 May 2021
... ) Competing interests The authors declare no competing or financial interests. © 2021. Published by The Company of Biologists Ltd 2021 Summary: This Review discusses the role of actin-binding protein profilin1 in major diseaeses with cardiovascular associations including atherosclerosis...
Journal Articles
J Cell Sci (2019) 132 (23): jcs237271.
Published: 02 December 2019
...Rajesh K. Singh; Frederik W. Lund; Abigail S. Haka; Frederick R. Maxfield ABSTRACT Low-density lipoprotein (LDL) deposition, aggregation and retention in the endothelial sub-intima are critical initiating events during atherosclerosis. Macrophages digest aggregated LDL (agLDL) through a process...
Includes: Supplementary data
Journal Articles
J Cell Sci (2019) 132 (11): jcs229542.
Published: 03 June 2019
... cell Atherosclerosis Mechanoreceptor Although multiple mechanoreceptors have been identified, the fundamental mechanisms that cells use to sense the direction of force remain largely unknown. Arteries are exposed to mechanical forces of differing direction and magnitude via the action...
Includes: Supplementary data
Journal Articles
J Cell Sci (2016) 129 (8): 1580–1591.
Published: 15 April 2016
...Arif Yurdagul, Jr; Florian J. Sulzmaier; Xiao L. Chen; Christopher B. Pattillo; David D. Schlaepfer; A. Wayne Orr ABSTRACT Oxidized low-density lipoprotein (oxLDL) accumulates early in atherosclerosis and promotes endothelial nuclear factor κB (NF-κB) activation, proinflammatory gene expression...
Includes: Supplementary data
Journal Articles
J Cell Sci (2011) 124 (23): 4115–4124.
Published: 01 December 2011
... ). Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) transcriptional regulation by Oct-1 in human endothelial cells: implications for atherosclerosis . Biochem. J. 393 , 255 - 265 . Chen K. C. , Wang Y. S. , Hu C. Y. , Chang W. C. , Liao Y. C. , Dai C. Y...
Includes: Supplementary data
Journal Articles
J Cell Sci (2009) 122 (11): 1863–1871.
Published: 01 June 2009
... and cellular responses (Smad2 phosphorylation/nuclear localization and expression of PAI-1). Dynasore, a newly identified inhibitor of dynamin GTPase activity, is one of the most potent inhibitors among those tested and, furthermore, is a potent enhancer of TGFβ. Dynasore ameliorates atherosclerosis...
Includes: Supplementary data
Journal Articles
J Cell Sci (2007) 120 (13): 2223–2231.
Published: 01 July 2007
... network abrogated all the observed effects, suggesting that cholesterol affects the mechanical properties of a cell through the underlying cytoskeleton. The results of these quantitative studies may help to better understand the biomechanical processes accompanying the development of atherosclerosis...
Journal Articles
J Cell Sci (2005) 118 (8): 1587–1594.
Published: 15 April 2005
... microbial and human HSP act as dominant antigens in numerous infectious and autoimmune diseases such as atherosclerosis, inducing a strong immune-inflammatory response. In the present study, the surface localization of HSP60 on stressed and unstressed human umbilical venous endothelial cells (HUVECs...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2004) 117 (2): 327–337.
Published: 15 January 2004
..., and extends our knowledge in SR-BI-mediated cholesterol transport. * Author for correspondence (e-mail: levye@justine.umontreal.ca ) 5 9 2003 © The Company of Biologists Limited 2004 2004 SR-BI Enterocyte Cholesterol transport Caveolin-1 Malabsorption Atherosclerosis...