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Keywords: Atherosclerosis
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Journal Articles
Journal Articles
Journal Articles
J Cell Sci (2022) 135 (5): jcs254631.
Published: 22 October 2021
... affects VSMC proliferation and migration, impacting atherosclerosis. In summary, this work shows that ChA is sufficient to induce lysosomal dysfunction in VSMCs, that, in ChA-treated VSMCs, neither lysosome biogenesis nor autophagy are triggered, and, finally, that recombinant LAL can be a therapeutic...
Includes: Supplementary data
Journal Articles
J Cell Sci (2021) 134 (9): jcs249060.
Published: 7 May 2021
... ). Diabetes and atherosclerosis: epidemiology, pathophysiology, and management . JAMA 287 , 2570 - 2581 . 10.1001/jama.287.19.2570 Böttcher , R. T. , Wiesner , S. , Braun , A. , Wimmer , R. , Berna , A. , Elad , N. , Medalia , O. , Pfeifer , A. , Aszódi...
Journal Articles
J Cell Sci (2019) 132 (23): jcs237271.
Published: 2 December 2019
...Rajesh K. Singh; Frederik W. Lund; Abigail S. Haka; Frederick R. Maxfield ABSTRACT Low-density lipoprotein (LDL) deposition, aggregation and retention in the endothelial sub-intima are critical initiating events during atherosclerosis. Macrophages digest aggregated LDL (agLDL) through a process...
Includes: Supplementary data
Journal Articles
J Cell Sci (2019) 132 (11): jcs229542.
Published: 3 June 2019
.... A. ( 2018 ). Inhibiting integrin 5 cytoplasmic domain signaling reduces atherosclerosis and promotes arteriogenesis . J. Am. Heart Assoc.   7 , e007501 . 10.1161/JAHA.117.007501 Buschmann , I. , Pries , A. , Styp-Rekowska , B. , Hillmeister , P. , Loufrani , L. , Henrion , D...
Includes: Supplementary data
Journal Articles
J Cell Sci (2016) 129 (8): 1580–1591.
Published: 15 April 2016
...Arif Yurdagul, Jr; Florian J. Sulzmaier; Xiao L. Chen; Christopher B. Pattillo; David D. Schlaepfer; A. Wayne Orr ABSTRACT Oxidized low-density lipoprotein (oxLDL) accumulates early in atherosclerosis and promotes endothelial nuclear factor κB (NF-κB) activation, proinflammatory gene expression...
Includes: Supplementary data
Journal Articles
J Cell Sci (2011) 124 (23): 4115–4124.
Published: 1 December 2011
... feedback regulation between let-7g and LOX-1, and indicate that let-7g could be a target to treat cardiovascular disease. Intracellular Ca 2+ was a well-known upstream regulator of PKC that participates in the development of atherosclerosis ( Velarde et al., 2001 ). Therefore, intracellular Ca 2+ might...
Includes: Supplementary data
Journal Articles
J Cell Sci (2009) 122 (11): 1863–1871.
Published: 1 June 2009
... and cellular responses (Smad2 phosphorylation/nuclear localization and expression of PAI-1). Dynasore, a newly identified inhibitor of dynamin GTPase activity, is one of the most potent inhibitors among those tested and, furthermore, is a potent enhancer of TGFβ. Dynasore ameliorates atherosclerosis...
Includes: Supplementary data
Journal Articles
J Cell Sci (2007) 120 (13): 2223–2231.
Published: 1 July 2007
... network abrogated all the observed effects, suggesting that cholesterol affects the mechanical properties of a cell through the underlying cytoskeleton. The results of these quantitative studies may help to better understand the biomechanical processes accompanying the development of atherosclerosis...
Journal Articles
J Cell Sci (2005) 118 (8): 1587–1594.
Published: 15 April 2005
... microbial and human HSP act as dominant antigens in numerous infectious and autoimmune diseases such as atherosclerosis, inducing a strong immune-inflammatory response. In the present study, the surface localization of HSP60 on stressed and unstressed human umbilical venous endothelial cells (HUVECs...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2004) 117 (2): 327–337.
Published: 15 January 2004
.... The abnormalities of intestinal cholesterol transport can contribute to pathologic processes, including fat malabsorption or atherosclerosis, and emphasize the importance of the small gut in cholesterol homeostasis ( Davidson and Magun, 1993 ; Levy and Roy, 1989 ; Levy, 1992 ; Thomson and Dietschy, 1981...
Journal Articles
Journal Articles
Journal Articles
J Cell Sci (1998) 111 (19): 2977–2988.
Published: 10 January 1998
... of Biologists Ltd. 1998 Bradford-Hill criteria Atherosclerosis Hypertension Vessel branch point Smooth muscle α-actin Smooth muscle myosin heavy chain It has been known for many years that muscle tissue mass varies with the load imposed upon it. For example, exercise can cause an increase...
Journal Articles
Journal Articles