... protein Atg32. Despite our knowledge about the molecular mechanisms by which Atg32 controls mitophagy, its physiological roles in yeast survival and fitness remains less clear. Here, we demonstrate a requirement for Atg32 in promoting spermidine production during respiratory growth and heat-induced...

... or valinomycin changes the competition outcomes in favor of the wild-type mtDNA. This effect was significantly lower in cells with disrupted mitochondria fission or repression of the autophagy-related genes ATG8 , ATG32 or ATG33 , implying that heteroplasmic zygotes activate mitochondrial degradation in response...

... , the mitochondrial outer membrane protein Sc Atg32 interacts with the cytosolic adaptor protein Sc Atg11. Sc Atg11 then delivers the mitochondria to the pre-autophagosomal structure for autophagic degradation. Despite the importance of Sc Atg32 for mitophagy, the expression and functional regulation of Sc Atg32...