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Journal: Journal of Cell Science
J Cell Sci (2007) 120 (19): 3327–3335.
Published: 01 October 2007
... domains, through which it binds to various proteins, including β-catenin, axin, CtBP, Asefs, IQGAP1, EB1 and microtubules. Studies using mutant mice and cultured cells have demonstrated that APC suppresses canonical Wnt signalling, which is essential for tumorigenesis, development and homeostasis...