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Keywords: Arp2/3
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Journal Articles
J Cell Sci (2024) 137 (3): jcs261774.
Published: 12 February 2024
... and lead to immune dysregulation. Deficiency in ARPC1B, a component of the Arp2/3 complex, results in vascular neutrophilic inflammation; however, the mechanism remains unclear. Here, we generated human induced pluripotent stem cell (iPSC)-derived neutrophils (denoted iNeutrophils) that are deficient...
Includes: Supplementary data
Journal Articles
J Cell Sci (2024) 137 (1): jcs261332.
Published: 10 January 2024
...Artem I. Fokin; Arthur Boutillon; John James; Laura Courtois; Sophie Vacher; Gleb Simanov; Yanan Wang; Anna Polesskaya; Ivan Bièche; Nicolas B. David; Alexis M. Gautreau ABSTRACT The Rac1–WAVE–Arp2/3 pathway pushes the plasma membrane by polymerizing branched actin, thereby powering membrane...
Includes: Supplementary data
Journal Articles
J Cell Sci (2021) 134 (23): jcs258891.
Published: 9 December 2021
...Alexander Hirschhäuser; Marianne van Cann; Sven Bogdan ABSTRACT The WAVE regulatory complex (WRC) is the main activator of the Arp2/3 complex, promoting lamellipodial protrusions in migrating cells. The WRC is basally inactive but can be activated by Rac1 and phospholipids, and through...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (18): jcs247403.
Published: 24 September 2020
... proteins, including the Arp2/3 complex, profilin, cofilin and tropomyosin. We have previously reported that myosin 1b regulates the density of the actin network in the growth cone. Here, by performing in vitro F-actin gliding assays and total internal reflection fluorescence (TIRF) microscopy, we show...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (13): jcs243576.
Published: 8 July 2020
...), capping protein and Arp2/3 as new molecular components involved in the physical aspects of NE bud formation in a Drosophila model system. Interestingly, Wash affects NE budding in two ways: indirectly through general nuclear lamina disruption via an SHRC-independent interaction with Lamin B leading...
Includes: Supplementary data
Journal Articles
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J Cell Sci (2020) 133 (7): jcs239020.
Published: 9 April 2020
... of the Arp2/3 complex, at the leading edge. Using B16-F1 melanoma cell lines, we demonstrate that genetic ablation of Lpd compromises protrusion efficiency and coincident cell migration without altering essential parameters of lamellipodia, including their maximal rate of forward advancement and actin...
Includes: Supplementary data
Journal Articles
J Cell Sci (2019) 132 (8): jcs225029.
Published: 26 April 2019
... with Golgi-associated actin dots. MYO1C depletion leads to loss of cellular F-actin, and Golgi complex decompaction is also observed after inhibition or loss of the actin-related protein 2/3 complex, Arp2/3 (also known as ARPC). We show that the functional consequence of MYO1C depletion is a delay...
Includes: Supplementary data
Journal Articles
Journal Articles
J Cell Sci (2017) 130 (14): 2235–2241.
Published: 15 July 2017
...Olga Alekhina; Ezra Burstein; Daniel D. Billadeau ABSTRACT Proteins of the Wiskott–Aldrich syndrome protein (WASP) family function as nucleation-promoting factors for the ubiquitously expressed Arp2/3 complex, which drives the generation of branched actin filaments. Arp2/3-generated actin regulates...
Includes: Supplementary data
Journal Articles
J Cell Sci (2017) 130 (2): 420–428.
Published: 15 January 2017
... of the small GTPase RhoA in the assembly of the apical surface in nascent multiciliated cells is explored, revealing that RhoA and formin 1 control forces acting on the apical surface to regulate apical emergence. Apical emergence Actin Arp2/3 RhoA Fmn1 Multiciliated cells Epithelia...
Includes: Supplementary data
Journal Articles
J Cell Sci (2017) 130 (2): 344–359.
Published: 15 January 2017
...Benedikt M. Nagel; Meike Bechtold; Luis Garcia Rodriguez; Sven Bogdan ABSTRACT The Wiskott-Aldrich syndrome protein and SCAR homolog (WASH; also known as Washout in flies) is a conserved actin-nucleation-promoting factor controlling Arp2/3 complex activity in endosomal sorting and recycling...
Includes: Supplementary data
Journal Articles
J Cell Sci (2016) 129 (12): 2329–2342.
Published: 15 June 2016
... by The Company of Biologists Ltd 2016 Highlighted Article: Haptotaxis (directed migration) on a substrate-bound gradient is perhaps the least-well understood form of directed migration. We show that differential lamellipodial dynamics are crucial for this process. Haptotaxis Arp2/3 Lamellipodia...
Includes: Supplementary data
Journal Articles
Journal Articles
J Cell Sci (2014) 127 (1): 240–249.
Published: 1 January 2014
.... , Daugherty-Clarke   K. , Gelles   J. , Lappalainen   P. , Goode   B. L. ( 2010 ). GMF is a cofilin homolog that binds Arp2/3 complex to stimulate filament debranching and inhibit actin nucleation.   Curr. Biol.   20 , 861 – 867 . 10.1016/j.cub.2010.03.026 Haglund   C. M. , Welch   M...
Includes: Supplementary data
Journal Articles
Journal Articles
J Cell Sci (2012) 125 (16): 3790–3800.
Published: 15 August 2012
... binding partners identified the ARPC1 subunit of Arp2/3 actin nucleation complex essential for myoblast fusion. We demonstrate that CKIP-1, through binding to plasma membrane phosphoinositides via its PH domain, regulates cell morphology and lamellipodia formation by recruiting the Arp2/3 complex...
Includes: Supplementary data
Journal Articles
J Cell Sci (2012) 125 (1): 233–245.
Published: 1 January 2012
...-associated proteins. These interactions suggest a highly complex cadherin–actin interface. Moreover, mammalian αE-catenin has been implicated in a cadherin-independent cytoplasmic function in Arp2/3-dependent actin regulation, and in cell signaling. The function and regulation of individual molecular...
Includes: Supplementary data
Journal Articles
J Cell Sci (2009) 122 (21): 3983–3993.
Published: 1 November 2009
...Minna Roh-Johnson; Bob Goldstein The Arp2/3 complex is important for morphogenesis in various developmental systems, but specific in vivo roles for this complex in cells that move during morphogenesis are not well understood. We have examined cellular roles for Arp2/3 in the Caenorhabditis elegans...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2007) 120 (19): 3465–3474.
Published: 1 October 2007
... protrusion and reduced cell motility in time-lapse studies. These changes were correlated with a decrease in barbed-end formation and Arp2/3 localization at the cell edge, and a marked defect in actin filament branching, as revealed by rotary-shadowing scanning electron microscopy. Upstream of Arp2/3, Cdc42...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2007) 120 (10): 1779–1790.
Published: 15 May 2007
...Liang Cai; Alexander M. Makhov; James E. Bear Coronins are conserved F-actin binding proteins that have been implicated in a variety of processes including fibroblast migration, phagocytosis, and chemotaxis. Recent data from our lab indicate that coronin 1B coordinates Arp2/3-dependent actin...
Includes: Supplementary data