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Keywords: ArfGAP
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Journal Articles
J Cell Sci (2019) 132 (16): jcs232124.
Published: 29 August 2019
... of these pockets for Arf1 is expected to also accommodate an Arf GTPase-activating protein (ArfGAP). Structural evidence and protein interactions observed between isolated domains indirectly suggest that each niche preferentially recruits one of the two ArfGAPs known to affect COPI, i.e. Gcs1/ArfGAP1 and Glo3...
Includes: Supplementary data
Journal Articles
J Cell Sci (2018) 131 (5): jcs209890.
Published: 13 March 2018
...., 2002 ). Future work investigating the role of phosphorylation, the kinases mediating such modification and, possibly, other mechanisms regulating accessory proteins that are instrumental in the biogenesis of COPI-coated vesicles, such as the ArfGEFs and ArfGAPs, are key in understanding the regulation...
Includes: Supplementary data
Journal Articles
J Cell Sci (2016) 129 (10): 1963–1974.
Published: 15 May 2016
... of the functions of GIT, PIX and the GIT–PIX complex. ArfGAP GIT1 GIT2 RhoGEF α-PIX β-PIX Cell-surface receptors activate intracellular signaling through mediators such as small GTP-binding proteins, heterotrimeric G-proteins and protein kinases. Individual receptors often activate multiple...
Includes: Supplementary data
Journal Articles
J Cell Sci (2013) 126 (3): 756–766.
Published: 01 February 2013
... and dynamics through an ArfA-dependent mechanism. * Author for correspondence ( francois.letourneur@univ-lyon1.fr ) 19 11 2012 © 2013. Published by The Company of Biologists Ltd 2013 ArfGAP Cytokinesis Migration Actin cytoskeleton The ADP-ribosylation factor (Arf) proteins...
Includes: Supplementary data
Journal Articles
J Cell Sci (2010) 123 (14): 2381–2390.
Published: 15 July 2010
... at the interface between early endosomes and the TGN. Here, we have found that ARF1, but not ARF6 is required for early-endosomes-to-TGN transport of Shiga toxin. We inhibited the expression of six ArfGAP family members that have GAP activity to Arf1, and found that AGAP2 is required for retrograde transport...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2006) 119 (13): 2654–2666.
Published: 01 July 2006
... to those induced by an ArfGAP-defective mutant of GIT1 (p95-C2). Immunohistochemical analysis and immunoelectron microscopy reveal that these structures include the endogenous transferrin receptor. Time-lapse analysis during motogenic stimuli shows that the formation and perinuclear accumulation of the p95...
Journal Articles
J Cell Sci (2006) 119 (12): 2604–2612.
Published: 15 June 2006
... in protein transport, and classified them into three groups of intragenic complementation. In this study, we show that the overexpression of Glo3p, one of the GTPase-activating proteins of Arf1p (ArfGAP), suppresses the ts growth of a particular group of the arf1 mutants ( arf1-16 and arf1-17 ). Other...
Includes: Supplementary data
Journal Articles
J Cell Sci (2004) 117 (2): 155–161.
Published: 15 January 2004
... of their nuclear counterparts. The nuclear PLC-γ1/PIKE-S/PI 3-kinase signaling pathway seems to be an extension of the crosstalk between cytoplasmic PLC-γ1 and PI 3-kinase. PIKE-L contains a C-terminal extension consisting of an ADP ribosylation-GTPase-activating protein (ArfGAP) domain and two ankyrin repeats...