... that have not been seen in previous studies. These domes developed as a result of ECM swelling via aquaporin water transport activity. Based on computer simulation, uneven swelling, with a positive feedback between cell stretching and enhanced water transport, was a cause of dome formation. These results...

... the stratum corneum, the external barrier. Genes encoding different families of channel proteins have been found to harbour mutations linked to a variety of rare inherited monogenic skin diseases. In this Commentary, we discuss how human genetic findings in aquaporin (AQP) and transient receptor potential...

... and ubiquitylation of the membrane protein aquaporin-2 (AQP2) and demonstrate that phosphorylation can override the previously suggested dominant endocytic signal of K63-linked polyubiquitylation. In polarized epithelial cells, although S256 is an important phosphorylation site for AQP2 membrane localization...

...Jialu Liu; Ji Xu; Sumin Gu; Bruce J. Nicholson; Jean X. Jiang Both connexin 50 (Cx50) and aquaporin 0 (AQP0) have important roles in lens development and homeostasis, and their mutations are associated with human congenital cataracts. We have previously shown that Cx50 directly interacts with AQP0...

.... Biol. 12 , 2060 -2065. Klussmann, E., Tamma, G., Lorenz, D., Wiesner, B., Maric, K., Hofmann, F., Aktories, K., Valenti, G. and Rosenthal, W. ( 2001 ). An inhibitory role of Rho in the vasopressin-mediated translocation of aquaporin-2 into cell membranes of renal principal cells. J. Biol...

...A. S. Verkman Aquaporins (AQPs) are membrane proteins that transport water and, in some cases, also small solutes such as glycerol. AQPs are expressed in many fluid-transporting tissues, such as kidney tubules and glandular epithelia, as well as in non-fluid-transporting tissues, such as epidermis...

... and the subsequent translocation of water channels (aquaporin-2, AQP2) from intracellular vesicles into the plasma membrane. Prostaglandin E 2 (PGE 2 ) antagonizes AVP-induced water reabsorption; the signaling pathway underlying the diuretic response is not known. Using primary rat inner medullary collecting duct...

... exocytosis of aquaporin 2 (AQP2)-containing vesicles was investigated in AQP2-transfected renal CD8 cells. RT-PCR and western blot analysis confirmed the presence of the SNARE homologs VAMP/synaptobrevin-2, syntaxin-1, syntaxin-4 and SNAP-23 in CD8 cells. Tetanus neurotoxin (TeNT) was efficient in cleaving...

...Beatrice Nico; Antonio Frigeri; Grazia Paola Nicchia; Fabio Quondamatteo; Rainer Herken; Mariella Errede; Domenico Ribatti; Maria Svelto; Luisa Roncali ABSTRACT In this study, we have investigated the expression of aquaporin 4 during blood-brain barrier development in the optic tectum of chick...

... family: the human erythrocyte water channel aquaporin 1 (AQP1), the major intrinsic protein (MIP26) from bovine eye lens and a 25 kDa polypeptide (P25) from a water shunting complex found in the digestive tract of an homopteran sap-sucking insect ( Cicadella viridis ). Proteoliposomes containing either...

... aquaporin-2 for vasopressin-dependent concentration of urine . Science 264 , 92 – 95 . 10.1126/science.8140421 DiGiovanni , S. R. , Nielsen , S. , Christensen , E. I. and Knepper , M. A. ( 1994 ). Regulation of collecting duct water channel expression by vasopressin...