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Keywords: Apoptosis
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Journal Articles
J Cell Sci (2021) 134 (8): jcs244152.
Published: 22 April 2021
...) that link SAC activation to the initiation of cell death remain unknown. We show here that activated Cdk1 forms a complex with the pro-apoptotic proteins Bax and Bak (also known as BAK1) during SAC-induced apoptosis . Bax- and Bak-mediated delivery of activated Cdk1 to the mitochondrion is essential...
Includes: Supplementary data
Journal Articles
J Cell Sci (2021) 134 (6): jcs249276.
Published: 26 March 2021
... topoisomerase inhibitor. Thapsigargin-treated SEC24A -knockout cells showed a ∼2.5-fold increase in autophagic flux and ∼10-fold reduction in apoptosis compared to wild-type cells. Taken together, our findings indicate that SEC24A plays a previously unrecognized role in regulating association and Ca 2+ flux...
Includes: Supplementary data
Journal Articles
In collection:
Mitochondria
J Cell Sci (2021) 134 (3): jcs253401.
Published: 08 February 2021
... to the nucleus at the onset of stress and has anti-apoptotic properties that are enhanced by its interaction with p23 in an Hsp90-independent manner. Cyclophilin A Immunophilin p23 Mitochondria Apoptosis Trafficking Cyclophilin A (CyPA) is an abundant protein belonging to the...
Journal Articles
J Cell Sci (2021) 134 (2): jcs255422.
Published: 25 January 2021
... signalling and facilitate inflammation, differentiation and cell survival. TNF-Rs use distinct adaptor molecules to activate signalling cascades. Fas-associated protein with death domain (FADD) family adaptors often mediate apoptosis, and TNF-R-associated factor (TRAF) family adaptors mediate cell...
Includes: Supplementary data
Journal Articles
In collection:
Autophagy
J Cell Sci (2020) 133 (22): jcs246868.
Published: 16 November 2020
... treatment of the anti-tumor therapeutic reagent arsenite. IKKα triggers its own degradation, as a feedback loop, by activating p53-dependent autophagy, and therefore contributes substantially to hepatoma cell apoptosis induced by arsenite. Interestingly, IKKα is unable to interact with p53 directly but...
Journal Articles
J Cell Sci (2020) 133 (20): jcs244855.
Published: 26 October 2020
... that is required for the formation of glycogen-containing structures. Glycogen ER stress Glycogenin Glycogen synthase UPR Apoptosis The endoplasmic reticulum (ER) is an intracellular network of interconnected membranes involved in a variety of cellular processes including synthesis...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (10): jcs242636.
Published: 27 May 2020
...Elaheh Sadat Hosseini; Maryam Nikkhah; Amir Ali Hamidieh; Howard O. Fearnhead; Jean-Paul Concordet; Saman Hosseinkhani ABSTRACT Detection of the apoptosis signature becomes central in understanding cell death modes. We present here a whole-cell biosensor that detects Apaf-1 association and...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (9): jcs243931.
Published: 11 May 2020
...Priyanka S. Rana; Manabu Kurokawa; Michael A. Model ABSTRACT Potassium loss and persistent shrinkage have both been implicated in apoptosis but their relationship and respective roles remain controversial. We approached this problem by clamping intracellular sodium and potassium in HeLa or MDCK...
Journal Articles
In collection:
Mitochondria
J Cell Sci (2019) 132 (11): jcs224766.
Published: 31 May 2019
..., whether peroxisomes also regulate mitochondrial fission–fusion dynamics or mitochondrion-dependent apoptosis remained unclear. We now show that genetic ablation of the peroxins Pex3 or Pex5, which are essential for peroxisome biogenesis, results in mitochondrial fragmentation in mouse embryonic...
Includes: Supplementary data
Journal Articles
J Cell Sci (2019) 132 (10): jcs228478.
Published: 16 May 2019
... groups, and this increase exacerbated Dox-induced cardiomyocyte apoptosis and mitochondrial dysfunction. Overexpressing Dkk1 aggravated Dox-induced cardiotoxicity in H 9 C 2 cells. Similar results were detected when adding active Dkk1 protein extracellularly. Conversely, adding specific antibody blocking...
Includes: Supplementary data
Journal Articles
J Cell Sci (2019) 132 (9): jcs226274.
Published: 02 May 2019
...Shalini Roy; Shriya Saha; Purnima Gupta; Anindita Ukil; Pijush K. Das ABSTRACT Previously, we documented the role of the programmed death-1 (PD-1, also known as PDCD1) pathway in macrophage apoptosis and the downregulation of this signaling during infection by the intra-macrophage parasite...
Includes: Supplementary data
Journal Articles
J Cell Sci (2019) 132 (7): jcs223826.
Published: 04 April 2019
... ), and many of its interactions affect its stability. For instance, binding to X-linked inhibitor of apoptosis protein (XIAP) increases survivin turnover ( Arora et al., 2007 ), whereas integration into the CPC stabilises it ( Honda et al., 2003 ). In interphase, survivin localises to the...
Includes: Supplementary data
Journal Articles
J Cell Sci (2019) 132 (1): jcs218628.
Published: 02 January 2019
... approaches, we demonstrate that MAGEA1 has regulatory effects on BORIS via methylation of its promoter. These findings have implications for the function of cancer testis antigen genes in cancer cells. MAGEA1 CTCF BORIS Apoptosis Methylation Cancer testis antigens (CTAs) have been...
Includes: Supplementary data
Journal Articles
J Cell Sci (2018) 131 (17): jcs217760.
Published: 05 September 2018
... and unfolded protein response (UPR) pathways. Consequently, specific molecular chaperones have been validated as targets for anti-cancer therapies. For example, inhibition of Hsp70 family proteins (hereafter Hsp70) in rhabdomyosarcoma triggers UPR induction and apoptosis. To define how these cancer...
Includes: Supplementary data
Journal Articles
J Cell Sci (2018) 131 (10): jcs210575.
Published: 22 May 2018
...Victoria H. Ng; Brian I. Hang; Leah M. Sawyer; Leif R. Neitzel; Emily E. Crispi; Kristie L. Rose; Tessa M. Popay; Alison Zhong; Laura A. Lee; William P. Tansey; Stacey Huppert; Ethan Lee ABSTRACT X-linked inhibitor of apoptosis (XIAP) plays an important role in preventing apoptotic cell death. XIAP...
Includes: Supplementary data
Journal Articles
J Cell Sci (2018) 131 (10): jcs212753.
Published: 16 May 2018
... intracellular compartments and have distinct functions. Our results reveal that isoform 1 is an anti-apoptotic factor that inhibits staurosporine- and TNF-related apoptosis-inducing ligand (TRAIL; also known as TNFSF10)-induced apoptosis. In contrast, USP35 isoform 2 is an integral membrane protein of the...
Includes: Supplementary data
Journal Articles
J Cell Sci (2017) 130 (22): 3779–3787.
Published: 15 November 2017
... interests. © 2017. Published by The Company of Biologists Ltd 2017 Summary: Discussion of the biology of the PIDDosome multiprotein complex and of recent advances that link PIDDosome-dependent CASP2 activation to p53 activation in response to extra centrosomes. Apoptosis Caspase-2...
Journal Articles
J Cell Sci (2017) 130 (19): 3308–3321.
Published: 01 October 2017
... 285, 319, 321 and 325, Cx37-induced cell death was eliminated and the growth arrest period prolonged, and GJCh closed state probability was restored. With aspartate substitution at these seven sites, apoptosis was induced and the open state probability of large conductance GJChs (and hemichannels) was...
Includes: Supplementary data
Journal Articles
J Cell Sci (2017) 130 (18): 3124–3140.
Published: 15 September 2017
...Urska Repnik; Marita Borg Distefano; Martin Tobias Speth; Matthew Yoke Wui Ng; Cinzia Progida; Bernard Hoflack; Jean Gruenberg; Gareth Griffiths ABSTRACT L-leucyl-L-leucine methyl ester (LLOMe) induces apoptosis, which is thought to be mediated by release of lysosomal cysteine cathepsins from...
Includes: Supplementary data
Journal Articles
J Cell Sci (2017) 130 (15): 2606–2619.
Published: 01 August 2017
... survival of cultured cerebellar granule cells and survival of cerebellar granule and Purkinje cells in organotypic cultures. In histological sections from 10- and 14-day-old CHL1-deficient mice, enhanced apoptosis of granule, but not Purkinje, cells was observed. The results of the present study indicate...