...Ghislain Gillard; Katja Röper ABSTRACT Coordinated cell shape changes are a major driver of tissue morphogenesis, with apical constriction of epithelial cells leading to tissue bending. We previously identified that interplay between the apical-medial actomyosin, which drives apical constriction...

... contractility underlie this transition. Actomyosin contractility Apical constriction Cell migration Drosophila Pulsed contractions Biotechnology and Biological Sciences Research Council 10.13039/501100000268 BB/M021084/1 During development, morphogenetic processes ultimately...

...) and apical constriction. Both processes change the apical surface area of neuroepithelial cells, but how they are biomechanically integrated is unknown. Rho kinase (Rock; herein referring to both ROCK1 and ROCK2) inhibition in mouse whole embryo culture progressively widens the PNP. PNP widening...

... contractility, we examined the localization and function of Wtip, a member of the Ajuba family, in Xenopus early embryos. Targeted in vivo depletion of Wtip inhibited apical constriction in neuroepithelial cells and elicited neural tube defects. Fluorescent protein-tagged Wtip showed predominant punctate...

... in neurulation in Xenopus embryos. Morpholino-mediated depletion of GEF-H1 resulted in severe neural tube defects, which were rescued by GEF-H1 RNA. Lineage tracing of GEF-H1 morphants at different developmental stages revealed abnormal cell intercalation and apical constriction, suggesting that GEF-H1 regulates...

... ( [email protected] ) 11 4 2012 © 2012. Published by The Company of Biologists Ltd 2012 Adherens junction Cell shape change Apical constriction DE-Cadherin Gastrulation Mesoderm Cell shape changes are essential during development as principal events of morphogenesis...

... unveil a link between Crb and the organisation of the actin cytoskeleton during morphogenesis. * Author for correspondence ( [email protected] ) 9 9 2010 © 2011. 2011 Crumbs tracheal system apical constriction invagination morphogenesis subapical region Apicobasal...

... regulating epithelial cell shape. In our experiments, Lulu expression in epithelial cells resulted in apical constriction and lateral elongation in the cells, accompanied by upregulation of myosin-II. The inhibition of myosin-II activity almost completely blocked this Lulu-driven cell-shape change. We...

... cells for apical constriction. Movies available on-line: http://www.biologists.com/JCS/movies/jcs2073.html * Author for correspondence (e-mail: [email protected] ) 15 11 2000 © 2001 by Company of Biologists 2001 Mesoderm Invagination Gastrulation Apical...