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Keywords: Anoikis
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Journal Articles
J Cell Sci (2022) 135 (17): jcs258396.
Published: 30 August 2022
...Yu-Jhen Hsu; Yih-Jia Yin; Kai-Feng Tsai; Cian-Chun Jian; Zi-Wen Liang; Chien-Yu Hsu; Chun-Chao Wang ABSTRACT Epithelial morphogenesis and oncogenic transformation can cause loss of cell adhesion, and detached cells are eliminated by anoikis. Here, we reveal that transforming growth factor β...
Includes: Supplementary data
Journal Articles
J Cell Sci (2013) 126 (1): 21–29.
Published: 1 January 2013
... recurrence. One of the hallmarks of EMT is resistance of tumor cells to anoikis. This resistance contributes to metastasis and is a defining property not only of EMT but also of cancer stem cells. Here, we review the mechanistic coupling between EMT and resistance to anoikis. The discussion focuses...
Journal Articles
J Cell Sci (2011) 124 (19): 3189–3197.
Published: 1 October 2011
...Marta C. Guadamillas; Ana Cerezo; Miguel A. del Pozo Anoikis (or cell-detachment-induced apoptosis) is a self-defense strategy that organisms use to eliminate ‘misplaced’ cells, i.e. cells that are in an inappropriate location. Occasionally, detached or misplaced cells can overcome anoikis...
Journal Articles
Journal Articles
Journal Articles
J Cell Sci (2009) 122 (2): 171–177.
Published: 15 January 2009
.... Gilmore, A. P. ( 2005 ). Anoikis. Cell Death Differ. 12 Suppl. 2 , 1473 -1477. Gilmore, A. P., Metcalfe, A. D., Romer, L. H. and Streuli, C. H. ( 2000 ). Integrin-mediated survival signals regulate the apoptotic function of Bax through its conformation and subcellular localization. J. Cell...
Journal Articles
J Cell Sci (2008) 121 (4): 450–457.
Published: 15 February 2008
... activates the classical NF-κB pathway in MVECs and causes nuclear translocation of RelA/p65. This NF-κB activation prevents detachment-induced apoptosis (anoikis) of MVECs but does not inhibit apoptosis induced by removal of essential survival factors, including vascular endothelial growth factor (VEGF...
Journal Articles
J Cell Sci (2006) 119 (2): 271–282.
Published: 15 January 2006
...Rebeca Miñambres; Rosa M. Guasch; Amparo Perez-Aragó; Consuelo Guerri Anoikis is a programmed cell death induced by loss of anchorage that is involved in tissue homeostasis and disease. Ethanol is an important teratogen that induces marked central nervous system (CNS) dysfunctions. Here we show...
Journal Articles
Journal Articles
J Cell Sci (2004) 117 (18): 4043–4054.
Published: 15 August 2004
...Asha Manohar; Swati Ghosh Shome; John Lamar; Lee Stirling; Vandana Iyer; Kevin Pumiglia; C. Michael DiPersio Inadequate or inappropriate adhesion of epithelial cells to extracellular matrix leads to a form of apoptosis known as anoikis. During various tissue remodelling events, such as wound...
Journal Articles
J Cell Sci (2002) 115 (10): 2233–2239.
Published: 15 May 2002
... C, respectively. We have investigated the role of phospholipase C-γ1 in anoikis, or cell death,induced by the loss of extracellular matrix adhesion. Spontaneously immortalized mouse embryonic fibroblasts nullizygous at the Plcg1 locus ( Plcg1 -/- ), referred to as Null cells, were derived from...
Journal Articles
J Cell Sci (2001) 114 (13): 2375–2382.
Published: 1 July 2001
... that it has a crucial role in normal development. Functions for PTEN have been identified in the regulation of many normal cell processes, including growth, adhesion, migration, invasion and apoptosis. PTEN appears to play particularly important roles in regulating anoikis (apoptosis of cells after loss...