...Yu-Jhen Hsu; Yih-Jia Yin; Kai-Feng Tsai; Cian-Chun Jian; Zi-Wen Liang; Chien-Yu Hsu; Chun-Chao Wang ABSTRACT Epithelial morphogenesis and oncogenic transformation can cause loss of cell adhesion, and detached cells are eliminated by anoikis. Here, we reveal that transforming growth factor β...

... recurrence. One of the hallmarks of EMT is resistance of tumor cells to anoikis. This resistance contributes to metastasis and is a defining property not only of EMT but also of cancer stem cells. Here, we review the mechanistic coupling between EMT and resistance to anoikis. The discussion focuses...

...Marta C. Guadamillas; Ana Cerezo; Miguel A. del Pozo Anoikis (or cell-detachment-induced apoptosis) is a self-defense strategy that organisms use to eliminate ‘misplaced’ cells, i.e. cells that are in an inappropriate location. Occasionally, detached or misplaced cells can overcome anoikis...

...Keneshia K. Haenssen; Sarah A. Caldwell; Kristina S. Shahriari; S. RaElle Jackson; Kelly A. Whelan; Andres J. Klein-Szanto; Mauricio J. Reginato ErbB2, a receptor tyrosine kinase highly expressed in many tumors, is known to inhibit apoptotic signals. Overexpression of ErbB2 causes anoikis...

... differentiate or undergo apoptosis depending on their local adhesive interactions. Apoptosis in response to an inappropriate ECM environment is termed `anoikis', or homelessness. Several studies, utilising a variety of cell types, have indicated a common, crucial role for focal adhesion kinase (FAK...

.... Cell Dev. Biol. 19 , 173 -206. Gilmore, A. P. (2005). Anoikis. Cell Death Differ. 12 Suppl. 2 , 1473 -1477. Gilmore, A. P., Metcalfe, A. D., Romer, L. H. and Streuli, C. H. (2000). Integrin-mediated survival signals regulate the apoptotic function of Bax through its conformation...

... activates the classical NF-κB pathway in MVECs and causes nuclear translocation of RelA/p65. This NF-κB activation prevents detachment-induced apoptosis (anoikis) of MVECs but does not inhibit apoptosis induced by removal of essential survival factors, including vascular endothelial growth factor (VEGF...

...Rebeca Miñambres; Rosa M. Guasch; Amparo Perez-Aragó; Consuelo Guerri Anoikis is a programmed cell death induced by loss of anchorage that is involved in tissue homeostasis and disease. Ethanol is an important teratogen that induces marked central nervous system (CNS) dysfunctions. Here we show...

...Alessandra Marconi; Paola Atzei; Cristina Panza; Chiara Fila; Rossana Tiberio; Francesca Truzzi; Tina Wachter; Martin Leverkus; Carlo Pincelli β 1 -integrin protects keratinocyte stem cells (KSC) from cell-detachment apoptosis (`anoikis'). Here we show that caspase-8 active protein is detected...

...Asha Manohar; Swati Ghosh Shome; John Lamar; Lee Stirling; Vandana Iyer; Kevin Pumiglia; C. Michael DiPersio Inadequate or inappropriate adhesion of epithelial cells to extracellular matrix leads to a form of apoptosis known as anoikis. During various tissue remodelling events, such as wound...

... C, respectively. We have investigated the role of phospholipase C-γ1 in anoikis, or cell death,induced by the loss of extracellular matrix adhesion. Spontaneously immortalized mouse embryonic fibroblasts nullizygous at the Plcg1 locus (Plcg1 -/-), referred to as Null cells, were derived from...

... that it has a crucial role in normal development. Functions for PTEN have been identified in the regulation of many normal cell processes, including growth, adhesion, migration, invasion and apoptosis. PTEN appears to play particularly important roles in regulating anoikis (apoptosis of cells after loss...