..., or the transcriptional levels of any β-spectrin or any ankyrin, but secondarily reduced by about 80% the steady state protein levels of βII- and βIII-spectrin. Residual βII- and βIII-spectrin and ankyrins B and G were concentrated at the apical membrane of bronchial and renal epithelial cells, without impacting cell...

...Maegen A. Ackermann; Andrew P. Ziman; John Strong; Yinghua Zhang; April K. Hartford; Christopher W. Ward; William R. Randall; Aikaterini Kontrogianni-Konstantopoulos; Robert J. Bloch Small ankyrin 1 (sAnk1; Ank1.5) is a ~20 kDa protein of striated muscle that concentrates in the network compartment...

... mediates interactions with ankyrin proteins. Here, we investigate the importance of obscurin for SR architecture and organization. Lack of obscurin in cross-striated muscles leads to changes in longitudinal SR architecture and disruption of small ankyrin-1.5 (sAnk1.5) expression and localization. Changes...

...Sourav Ghosh; Frank C. Dorsey; John V. Cox Previous analyses have shown that the phosphorylation state of chicken erythroid ankyrin regulates its association with the spectrin cytoskeleton in vivo. Treatment of erythroid cells with serine and threonine phosphatase inhibitors stimulates...

...Scott M. Jenkins; Krishnakumar Kizhatil; Neal R. Kramarcy; Anindita Sen; Robert Sealock; Vann Bennett Phosphorylation of neurofascin, a member of the L1 family of cell adhesion molecules (L1 CAMs), at the conserved FIGQY-tyrosine abolishes the ankyrin-neurofascin interaction. This study provides...

... of the Na,K-ATPase colocalize with β-spectrin and ankyrin 3 in costameres, structures at the sarcolemma that lie over Z and M-lines and in longitudinal strands. In immunoprecipitates, the α1 and α2 subunits of the Na,K-ATPase as well as ankyrin 3 associate with β-spectrin/α-fodrin heteromers and with a pool...

... such as ankyrin link spectrin to other membrane proteins. Direct interactions of spectrin with actin and centractin (ARP1) provide a link to dynein, myosin and presumably other motors involved with intracellular transport. Building on the recognized ability of spectrin to organize macromolecular complexes...

...Ekaterini Kordeli; Marie-Aline Ludosky; Christiane Deprette; Thierry Frappier; Jean Cartaud ABSTRACT Ankyrins are a multi-gene family of peripheral proteins that link ion channels and cell adhesion molecules to the spectrin-based skeleton in specialized membrane domains. In the mammalian skeletal...

...Kenneth A. Beck; Jo Ann Buchanan; W. James Nelson ABSTRACT To extend our finding of a Golgi-localized form of the membrane skeleton protein spectrin, we have identified an isoform of ankyrin that associates at steady state with the Golgi complex. Immuno-light and -electron microscopy show...

...., 1987 ; Cleveland et al., 1991 ; Yamasaki et al., 1992 ), a crucial determinant for conduction velocity of axons and perhaps also a trigger for myelination ( Arbuthnott et al., 1980 ; Voyvodic, 1989 ). membrane-cytoskeleton linkage spectrin ankyrin cell adhesion molecule Ig-super family...

...Jonathan Q. Davis; Vann Bennett ABSTRACT A family of ankyrin-binding glycoproteins have been identified in adult rat brain that include alternatively spliced products of the same pre-mRNA. A composite sequence of ankyrin-binding glycoprotein (ABGP) shares 72% amino acid sequence identity...

...Catherine W. Morgans; Ron R. Kopito ABSTRACT The 89 kDa NH2-terminal domain of erythrocyte ankyrin is composed almost entirely of 22 tandem repeats of a 33 amino acid sequence and constitutes the binding site for the cytoplasmic NH2-terminal domain of the erythrocyte anion exchanger, AE1. We have...