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Keywords: Angiogenesis
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Journal Articles
J Cell Sci (2024) 137 (8): jcs261687.
Published: 30 April 2024
...Aukie Hooglugt; Miesje M. van der Stoel; Apeksha Shapeti; Beau F. Neep; Annett de Haan; Hans van Oosterwyck; Reinier A. Boon; Stephan Huveneers ABSTRACT Angiogenesis is a tightly controlled dynamic process demanding a delicate equilibrium between pro-angiogenic signals and factors that promote...
Includes: Supplementary data
Journal Articles
J Cell Sci (2023) 136 (10): jcs260657.
Published: 25 May 2023
...William R. Critchley; Gina A. Smith; Ian C. Zachary; Michael A. Harrison; Sreenivasan Ponnambalam ABSTRACT Vascular endothelial growth factor receptor 2 (VEGFR2, encoded by KDR ) regulates endothelial function and angiogenesis. VEGFR2 undergoes ubiquitination that programs this receptor...
Includes: Supplementary data
Journal Articles
J Cell Sci (2023) 136 (2): jcs260270.
Published: 27 January 2023
...Yao Xiao; Mingliang Li; Teng Ma; Hao Ning; Libo Liu ABSTRACT AMG232 effectively inhibits cancers with wild-type p53 (also known as TP53) by reactivating p53, but whether it inhibits glioma angiogenesis remains unclear. This study confirms that AMG232 inhibits the proliferation of glioma endothelial...
Includes: Supplementary data
Journal Articles
J Cell Sci (2023) 136 (1): jcs260182.
Published: 3 January 2023
...Julian Rapp; Malte Jung; Rhena F. U. Klar; Julian Wolf; Jakob Arnold; Oliver Gorka; Olaf Groß; Clemens Lange; Hansjürgen Agostini; Günther Schlunck; Felicitas Bucher ABSTRACT Aberrant angiogenesis is a hallmark of cardiovascular and retinal neovascular disease. The STAT3 signaling pathway...
Includes: Supplementary data
Journal Articles
In collection:
Cell migration
J Cell Sci (2022) 135 (6): jcs259468.
Published: 14 March 2022
...Wenjing Liu; Xiaoyan Jiang; Xiao Li; Kuanxiang Sun; Yeming Yang; Mu Yang; Shujin Li; Xianjun Zhu ABSTRACT Precise Norrin and β-catenin (Norrin/β-catenin; encoded by NDP and CTNNB1 , respectively) signaling is critical for proper angiogenesis. Dysregulation of this signaling leads to various...
Includes: Supplementary data
Journal Articles
J Cell Sci (2021) 134 (15): jcs254920.
Published: 2 August 2021
...Kiyomi Tsuji-Tamura; Saori Morino-Koga; Shingo Suzuki; Minetaro Ogawa ABSTRACT Elongation of vascular endothelial cells (ECs) is an important process in angiogenesis; however, the molecular mechanisms remain unknown. The actin-crosslinking protein TAGLN (transgelin, also known as SM22 or SM22α...
Includes: Supplementary data
Journal Articles
Journal Articles
J Cell Sci (2020) 133 (12): jcs239434.
Published: 15 June 2020
... no competing or financial interests. © 2020. Published by The Company of Biologists Ltd 2020 Summary: αvβ8 integrin is essential for normal organ development and physiology and integrin dysfunction is linked to multiple human diseases. Extracellular matrix Cancer Angiogenesis...
Journal Articles
In collection:
Adhesion
J Cell Sci (2020) 133 (11): jcs246595.
Published: 11 June 2020
...Hao Xu; Kevin Pumiglia; Susan E. LaFlamme ABSTRACT During angiogenesis, endothelial cells engage components of the extracellular matrix through integrin-mediated adhesion. Endothelial expression of laminin-411 and laminin-511 is known to promote vessel stability. However, little is known about...
Includes: Supplementary data
Journal Articles
In collection:
Adhesion
J Cell Sci (2020) 133 (7): jcs235762.
Published: 8 April 2020
...Jordi Lambert; Kate Makin; Sophia Akbareian; Robert Johnson; Abdullah A. A. Alghamdi; Stephen D. Robinson; Dylan R. Edwards ABSTRACT ADAMTS-1 is an extracellular protease with critical roles in organogenesis and angiogenesis. Here we demonstrate a functional convergence of ADAMTS-1...
Includes: Supplementary data
Journal Articles
Journal Articles
J Cell Sci (2020) 133 (5): jcs236075.
Published: 26 September 2019
... ). Wound healing angiogenesis: innovations and challenges in acute and chronic wound healing . Adv. Wound Care   1 , 17 - 22 . 10.1089/wound.2011.0308 Doloff , J. C. , Veiseh , O. , Vegas , A. J. , Tam , H. H. , Farah , S. , Ma , M. , Li , J. , Bader , A. , Chiu...
Journal Articles
J Cell Sci (2019) 132 (7): jcs225052.
Published: 3 April 2019
... vascular angiogenesis, which is a fundamental process in vascular development. Our data indicate that knockdown of TMEM30A in primary human retinal endothelial cells led to reduced tube formation. In mice, endothelial cell (EC)-specific deletion of Tmem30a led to retarded retinal vascular development...
Includes: Supplementary data
Journal Articles
J Cell Sci (2018) 131 (3): jcs210492.
Published: 2 February 2018
...Julienne Chaqour; Sangmi Lee; Aashreya Ravichandra; Brahim Chaqour ABSTRACT Abscisic acid (ABA) has shown anti-inflammatory and immunoregulatory properties in preclinical models of diabetes and inflammation. Herein, we studied the effects of ABA on angiogenesis, a strictly controlled process...
Includes: Supplementary data
Journal Articles
J Cell Sci (2017) 130 (9): 1583–1595.
Published: 1 May 2017
... is a key feature in tumour blood vessel stabilisation and pericyte recruitment, processes that are important in the growth and maturation of tumour blood vessels. However, the role of pericyte α6β1-integrin in angiogenesis is largely unknown. We developed mice where the α6-integrin subunit is deleted...
Includes: Supplementary data
Journal Articles
J Cell Sci (2016) 129 (11): 2182–2189.
Published: 1 June 2016
...Xiaolei Liang; Lina Zhang; Shihua Wang; Qin Han; Robert Chunhua Zhao ABSTRACT Angiogenesis plays crucial roles in various physiological processes including wound healing and tissue repair. It requires a tight interaction between endothelial cells and their surrounding environment. Mesenchymal stem...
Includes: Supplementary data
Journal Articles
J Cell Sci (2016) 129 (6): 1210–1222.
Published: 15 March 2016
.... S2D ). These data suggest that the AGS8–Gβγ complex, rather than a simple Gβγ signal input, is required by endothelial cells for the induction of angiogenesis. Fig. 8. Effect of AGS8 peptide on VEGF-induced tube formation and VEGFR-2 phosphorylation. (A) The efficiency of peptide uptake...
Includes: Supplementary data
Journal Articles
J Cell Sci (2016) 129 (4): 743–756.
Published: 15 February 2016
...Jui M. Dave; Colette A. Abbey; Camille L. Duran; Heewon Seo; Gregory A. Johnson; Kayla J. Bayless ABSTRACT During angiogenesis, endothelial cells must coordinate matrix proteolysis with migration. Here, we tested whether the focal adhesion scaffold protein Hic-5 (also known as TGFB1I1) regulated...
Includes: Supplementary data
Journal Articles
J Cell Sci (2016) 129 (4): 693–705.
Published: 15 February 2016
... proliferator-activated receptor gamma (PPARγ, also known as PPARG) in mice leads to osteopetrosis and pulmonary arterial hypertension. Vascular disease is associated with loss of PPARγ in pulmonary microvascular endothelial cells (PMVEC); we evaluated the role of PPARγ in PMVEC functions, such as angiogenesis...
Includes: Supplementary data
Journal Articles
J Cell Sci (2014) 127 (21): 4788–4799.
Published: 1 November 2014
...Giulia De Rossi; Alun R. Evans; Emma Kay; Abigail Woodfin; Tristan R. McKay; Sussan Nourshargh; James R. Whiteford ABSTRACT Angiogenesis is essential for the development of a normal vasculature, tissue repair and reproduction, and also has roles in the progression of diseases such as cancer...
Includes: Supplementary data