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Keywords: Angiogenesis
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Journal Articles
J Cell Sci (2021) 134 (1): jcs250274.
Published: 11 January 2021
... development and embryonic lethality. Although hypoxia is implicated in vascular remodelling and angiogenesis, its effect on PTP-PEST remains unexplored. Here we report that hypoxia (1% oxygen) increases protein levels and catalytic activity of PTP-PEST in primary endothelial cells. Immunoprecipitation...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (12): jcs239434.
Published: 15 June 2020
... competing or financial interests. © 2020. Published by The Company of Biologists Ltd 2020 Summary: αvβ8 integrin is essential for normal organ development and physiology and integrin dysfunction is linked to multiple human diseases. Extracellular matrix Cancer Angiogenesis...
Journal Articles
In collection:
Adhesion
J Cell Sci (2020) 133 (11): jcs246595.
Published: 11 June 2020
...Hao Xu; Kevin Pumiglia; Susan E. LaFlamme ABSTRACT During angiogenesis, endothelial cells engage components of the extracellular matrix through integrin-mediated adhesion. Endothelial expression of laminin-411 and laminin-511 is known to promote vessel stability. However, little is known about the...
Includes: Supplementary data
Journal Articles
In collection:
Adhesion
J Cell Sci (2020) 133 (7): jcs235762.
Published: 08 April 2020
...Jordi Lambert; Kate Makin; Sophia Akbareian; Robert Johnson; Abdullah A. A. Alghamdi; Stephen D. Robinson; Dylan R. Edwards ABSTRACT ADAMTS-1 is an extracellular protease with critical roles in organogenesis and angiogenesis. Here we demonstrate a functional convergence of ADAMTS-1 and the...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (3): jcs239947.
Published: 12 February 2020
... YAP/TAZ (YAP is also known as YAP1, and TAZ as WWTR1) signaling is crucial for sprouting angiogenesis and vascular homeostasis. However, the underlying molecular mechanisms that explain how YAP/TAZ control the vasculature remain unclear. This study reveals that the focal adhesion protein deleted-in...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (5): jcs236075.
Published: 26 September 2019
... window on the pathological angiogenic and fibrotic response to suture implantation and how this can be modulated by genetically or pharmacologically dampening inflammation. Angiogenesis Fibrosis Foreign body Inflammation Wound Zebrafish The surgical implantation of medical devices and...
Journal Articles
J Cell Sci (2019) 132 (7): jcs225052.
Published: 03 April 2019
... vascular angiogenesis, which is a fundamental process in vascular development. Our data indicate that knockdown of TMEM30A in primary human retinal endothelial cells led to reduced tube formation. In mice, endothelial cell (EC)-specific deletion of Tmem30a led to retarded retinal vascular development with...
Includes: Supplementary data
Journal Articles
J Cell Sci (2018) 131 (3): jcs210492.
Published: 02 February 2018
...Julienne Chaqour; Sangmi Lee; Aashreya Ravichandra; Brahim Chaqour ABSTRACT Abscisic acid (ABA) has shown anti-inflammatory and immunoregulatory properties in preclinical models of diabetes and inflammation. Herein, we studied the effects of ABA on angiogenesis, a strictly controlled process that...
Includes: Supplementary data
Journal Articles
J Cell Sci (2017) 130 (9): 1583–1595.
Published: 01 May 2017
... key feature in tumour blood vessel stabilisation and pericyte recruitment, processes that are important in the growth and maturation of tumour blood vessels. However, the role of pericyte α6β1-integrin in angiogenesis is largely unknown. We developed mice where the α6-integrin subunit is deleted in...
Includes: Supplementary data
Journal Articles
J Cell Sci (2016) 129 (11): 2182–2189.
Published: 01 June 2016
...Xiaolei Liang; Lina Zhang; Shihua Wang; Qin Han; Robert Chunhua Zhao ABSTRACT Angiogenesis plays crucial roles in various physiological processes including wound healing and tissue repair. It requires a tight interaction between endothelial cells and their surrounding environment. Mesenchymal stem...
Includes: Supplementary data
Journal Articles
J Cell Sci (2016) 129 (6): 1210–1222.
Published: 15 March 2016
... input to angiogenesis by AGS8 is suggested. Angiogenesis VEGF Endothelial cell G protein AGS protein Angiogenesis is the formation of new blood vessels from the existing vascular network, which is induced under physiological and pathophysiological stimuli, including hypoxia and...
Includes: Supplementary data
Journal Articles
J Cell Sci (2016) 129 (4): 743–756.
Published: 15 February 2016
...Jui M. Dave; Colette A. Abbey; Camille L. Duran; Heewon Seo; Gregory A. Johnson; Kayla J. Bayless ABSTRACT During angiogenesis, endothelial cells must coordinate matrix proteolysis with migration. Here, we tested whether the focal adhesion scaffold protein Hic-5 (also known as TGFB1I1) regulated...
Includes: Supplementary data
Journal Articles
J Cell Sci (2016) 129 (4): 693–705.
Published: 15 February 2016
... proliferator-activated receptor gamma (PPARγ, also known as PPARG) in mice leads to osteopetrosis and pulmonary arterial hypertension. Vascular disease is associated with loss of PPARγ in pulmonary microvascular endothelial cells (PMVEC); we evaluated the role of PPARγ in PMVEC functions, such as angiogenesis...
Includes: Supplementary data
Journal Articles
J Cell Sci (2014) 127 (21): 4788–4799.
Published: 01 November 2014
...Giulia De Rossi; Alun R. Evans; Emma Kay; Abigail Woodfin; Tristan R. McKay; Sussan Nourshargh; James R. Whiteford ABSTRACT Angiogenesis is essential for the development of a normal vasculature, tissue repair and reproduction, and also has roles in the progression of diseases such as cancer and...
Includes: Supplementary data
Journal Articles
J Cell Sci (2014) 127 (20): 4331–4341.
Published: 15 October 2014
...Peter Stapor; Xingwu Wang; Jermaine Goveia; Stijn Moens; Peter Carmeliet ABSTRACT Clinically approved therapies that target angiogenesis in tumors and ocular diseases focus on controlling pro-angiogenic growth factors in order to reduce aberrant microvascular growth. Although research on...
Journal Articles
J Cell Sci (2014) 127 (20): 4518–4530.
Published: 15 October 2014
...Kaori H. Yamada; Yuki Nakajima; Melissa Geyer; Kishore K. Wary; Masuko Ushio-Fukai; Yulia Komarova; Asrar B. Malik ABSTRACT Although the trafficking of newly synthesized VEGFR2 to the plasma membrane is a key determinant of angiogenesis, the molecular mechanisms of Golgi to plasma membrane...
Includes: Supplementary data
Journal Articles
J Cell Sci (2014) 127 (18): 3983–3997.
Published: 15 September 2014
...Cornelia M. Wilson; Thomas Naves; François Vincent; Boris Melloni; François Bonnaud; Fabrice Lalloué; Marie-Odile Jauberteau ABSTRACT The transfer of exosomes containing both genetic and protein materials is necessary for the control of the cancer cell microenvironment to promote tumor angiogenesis...
Includes: Supplementary data
Journal Articles
J Cell Sci (2014) 127 (17): 3805–3816.
Published: 01 September 2014
...Anthony Ambesi; Paula J. McKeown-Longo ABSTRACT The fibronectin matrix plays a crucial role in the regulation of angiogenesis during development, tissue repair and pathogenesis. Previous work has identified a fibronectin-derived homophilic binding peptide, anastellin, as an effective inhibitor of...
Journal Articles
J Cell Sci (2014) 127 (14): 3039–3051.
Published: 15 July 2014
... phenocopying RhoJ knockdown. RhoJ-knockout mice showed reduced tumour growth and diminished tumour vessel density, identifying a role for RhoJ in mediating tumour angiogenesis. These studies give new insight into the molecular function of RhoJ in regulating cell motility and tumour vessel formation...
Includes: Supplementary data
Journal Articles
J Cell Sci (2014) 127 (9): 2017–2028.
Published: 01 May 2014
... endothelial cells (EC) in vivo , suggesting that angiogenic sprouting may share common attributes with EMT. Here, we demonstrate that sprouting EC in vitro express both Slug and Snail, and that siRNA-mediated knockdown of either inhibits sprouting and migration in multiple in vitro angiogenesis assays. We...
Includes: Supplementary data