... and cancer cells drives chromosome losses, which myosin-II suppression maximizes. Confinement Compression Myosin Rigidity Aneuploidy Heritability National Institutes of Health http://dx.doi.org/10.13039/100000002 National Cancer Institute http://dx.doi.org/10.13039/100000054...

... upregulation compromised mitotic spindle integrity and induced aneuploidy via micronuclei formation. Chromosomal instability Aneuploidy Micronuclei KIF11 Mitosis CRISPR activation Confocal imaging Machine learning Deep learning Cancer Research UK http://dx.doi.org/10.13039/501100000289...

... mammalian oocytes, and that these F-actin structures deteriorate with advancing reproductive age. Oocyte Nuclear F-actin Meiosis Aneuploidy Chromosome segregation Infertility Wellcome Trust http://dx.doi.org/10.13039/100010269 213470/Z/18/Z Royal Society http://dx.doi.org...

... overexpression of Tiam1 can restrict centriole overduplication. Ultimately, Tiam1 depletion leads to lagging chromosomes at anaphase and aneuploidy, which are potential drivers of malignant progression. The effects of Tiam1 depletion on centrosomal PLK4 levels and centriole overduplication can be rescued by re...

... mitosis Aneuploidy Pericentriolar matrix Oklahoma Medical Research Foundation 10.13039/100008907 P20GM103636 National Institute of General Medical Sciences 10.13039/100000057 R35GM126980 Mitosis accurately and evenly divides the replicated genome into two daughter...

... death due to replication stress and subsequent DSBs. Rad51 helps to repair breaks, but causes DNA rearrangements. Rad51 Srs2 Genome instability Aneuploidy Double-strand break Cell cycle control Narodowe Centrum Nauki 10.13039/501100004281 2016/21/B/NZ3/03641...

... Aneuploidy FP7 People: Marie-Curie Actions; 607722 KWF Kankerbestrijding 10.13039/501100004622 NKI-2015-7832 The presence of micronuclei is a hallmark of chromosome instability. Micronuclei are formed when one or a few chromosomes fail to join a daughter nucleus and form...

... of PP6c caused an abnormal MII spindle and disrupted MII cytokinesis, resulting in zygotes with high risk of aneuploidy and defective early embryonic development, and thus severe subfertility. We also reveal that PP6 inactivation interferes with MII spindle formation and MII exit owing to increased Aurora...

... interests. 13 02 2014 10 07 2014 © 2014. Published by The Company of Biologists Ltd 2014 STAG2 Aneuploidy Kinetochore Merotely Mitosis Chromosomal instability Chromosomes must be faithfully segregated during mitosis to allow for normal cellular growth and development...

... is a partial loss or gain of checkpoint function, leads to aneuploidy during tumorigenesis. One form of damage is a change in levels of the checkpoint proteins mitotic arrest deficient 1 and 2 (Mad1 and Mad2), or in the Mad1:Mad2 ratio. Changes in Mad1 and Mad2 levels occur in human cancers, where...

... findings imply random missegregation of chromosomes as the initial event in the generation of aneuploidy in mammalian somatic cells. References Albertson, D. G., Collins, C., McCormick, F. and Gray, J. W. ( 2003 ). Chromosome aberrations in solid tumors. Nat. Genet. 34 , 369 -376. Andrews, P...

... Aneuploidy Drosophila Troponin I (TnI) and Tropomyosin (Tm) are actin-binding proteins that regulate muscle sarcomere contraction. The Tn-Tm complex contains three different Troponin polypeptides, C, T and I, and it regulates acto-myosin interactions in response to the rise of free calcium ( Clark...

... but aneuploid karyotype. Both CIN and stable aneuploidy are commonly observed in cancers. Recently, it has been proposed that an increased number of chromosome sets can promote cell transformation and give rise to an aneuploid tumor. Here, we review how tetraploidy can occur and describe the cellular responses...

..., and its targeting is independent of microtubules (MTs) and several other known kinetochore components. Animals carrying mutations in mitch die as late third-instar larvae; mitotic neuroblasts in larval brains exhibit high levels of aneuploidy. Analysis of fixed D. melanogaster brains and mitch RNAi...

... this is a secondary consequence of its role in kinetochore assembly and/or regulating kinetochore-microtubule attachments is not clear. Mitosis Spindle checkpoint Kinetochore Aneuploidy © The Company of Biologists Limited 2005 2005 5 5 2005 * Author for correspondence (e...

...Daniela Cimini; Daniela Fioravanti; E. D. Salmon; Francesca Degrassi Defects in chromosome segregation play a critical role in producing genomic instability and aneuploidy, which are associated with congenital diseases and carcinogenesis. We recently provided evidence from immunofluorescence...

... effects on germ cells of error during meiosis. Analysis of sperm by three color fluorescence in situ hybridization revealed significantly elevated aneuploidy, thus validating Robertsonian heterozygous mice as a model for production of chromosomally abnormal gametes. Primary spermatocytes from heterozygous...

... Aneuploidy Chromosome loss Mammalian chromosome transmission assay GFP Chromosome segregation is the focus of intensive study because of its relevance to human disease and its central role in the cell cycle. Aneuploidy, the loss or gain of a chromosome, is estimated to occur in 13-25% of oocytes...