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Journal: Journal of Cell Science
J Cell Sci (2009) 122 (18): 3272–3281.
Published: 15 September 2009
...Catherine A. Cremona; Alison C. Lloyd Mammalian cells generally require both mitogens and anchorage signals in order to proliferate. An important characteristic of many tumour cells is that they have lost this anchorage-dependent cell-cycle checkpoint, allowing them to proliferate without signals...
Includes: Supplementary data