...Chenxi Zhou; Janelle L. Hancock; Kum Kum Khanna; Hayden A. Homer ABSTRACT During mitosis, anaphase is triggered by anaphase-promoting complex (APC)-mediated destruction of securin and cyclin B1, which leads to inactivation of cyclin-dependent kinase 1 (Cdk1). By regulating APC activity, the mitotic...

... Institute for Zoology and Anthropology, Berliner Strasse 28, 37073 Göttingen, Germany. Competing interests The authors declare no competing interests. 15 08 2013 8 05 2014 © 2014. Published by The Company of Biologists Ltd 2014 Anaphase-promoting complex Axonal...

... of PP2A-Cdc55 have not been clearly defined or are controversial. Here, we show that an important target of Cdc55 in the SAC is the anaphase-promoting complex (APC) coupled with Cdc20 and that APC-Cdc20 is kept inactive by dephosphorylation by nuclear PP2A-Cdc55 when spindle is damaged. By isolating a new...

... of eukaryotic pathways. Although Giardia has many cell cycle regulatory components, its genome lacks all anaphase-promoting complex (APC) components. In the present study, we show that a single mitotic cyclin in Giardia is essential for progression into mitosis. Strikingly, Giardia cyclin B lacks the conserved...

...–cullin1–F-box) and the APC/C (anaphase-promoting complex/cyclosome) are known for driving the degradation of cell cycle regulators to accomplish irreversible cell cycle transitions. The cell cycle machinery reciprocally regulates the SCF and APC/C through various mechanisms, including the modification...

... checkpoint is the anaphase-promoting complex/cyclosome (APC/C), an E3 ubiquitin ligase that targets several anaphase inhibitors for proteolysis, including securin and cyclin B1. In the presence of unattached kinetochores, the APC/C is inhibited by the mitotic checkpoint complex (MCC), a tetrameric complex...

... levels in the imaged cells. * These authors contributed equally to this work ‡ Authors for correspondence ([email protected] ; [email protected]) § These authors contributed equally to this work 31 3 2010 © 2010. 2010 Anaphase-promoting complex...

... was hypothesized more than 35 years ago, its precise identity remained unclear until recently. The discovery of the Mos-MAPK pathway and characterization of the anaphase-promoting complex/cyclosome (APC/C) as a central regulator of M-phase exit provided the framework for a molecular understanding of CSF...

...A. M. Bentley; Byron C. Williams; Michael L. Goldberg; Andrew J. Andres We have cloned and characterized the ida gene that is required for proliferation of imaginal disc cells during Drosophila development. IDA is homologous to APC5, a subunit of the anaphase-promoting complex(APC/cyclosome). ida...