Skip Nav Destination
Close Modal
Update search
Filter
- Title
- Author
- Author Affiliations
- Full Text
- Abstract
- Keyword
- DOI
- ISBN
- EISBN
- ISSN
- EISSN
- Issue
- Volume
- References
Filter
- Title
- Author
- Author Affiliations
- Full Text
- Abstract
- Keyword
- DOI
- ISBN
- EISBN
- ISSN
- EISSN
- Issue
- Volume
- References
Filter
- Title
- Author
- Author Affiliations
- Full Text
- Abstract
- Keyword
- DOI
- ISBN
- EISBN
- ISSN
- EISSN
- Issue
- Volume
- References
Filter
- Title
- Author
- Author Affiliations
- Full Text
- Abstract
- Keyword
- DOI
- ISBN
- EISBN
- ISSN
- EISSN
- Issue
- Volume
- References
Filter
- Title
- Author
- Author Affiliations
- Full Text
- Abstract
- Keyword
- DOI
- ISBN
- EISBN
- ISSN
- EISSN
- Issue
- Volume
- References
Filter
- Title
- Author
- Author Affiliations
- Full Text
- Abstract
- Keyword
- DOI
- ISBN
- EISBN
- ISSN
- EISSN
- Issue
- Volume
- References
NARROW
Format
Journal
Article Type
TOC Section
Date
Availability
1-2 of 2
Keywords: Amyloid-β
Close
Follow your search
Access your saved searches in your account
Would you like to receive an alert when new items match your search?
Sort by
Journal Articles
The cholesterol ester cycle regulates signalling complexes and synapse damage caused by amyloid-β
Free
Journal:
Journal of Cell Science
J Cell Sci (2017) 130 (18): 3050–3059.
Published: 15 September 2017
...Ewan West; Craig Osborne; Clive Bate ABSTRACT Cholesterol is required for the formation and function of some signalling platforms. In synaptosomes, amyloid-β (Aβ) oligomers, the causative agent in Alzheimer's disease, bind to cellular prion proteins (PrP C) resulting in increased cholesterol...
Journal Articles
SEPT8 modulates β-amyloidogenic processing of APP by affecting the sorting and accumulation of BACE1
FreeKaisa M. A. Kurkinen, Mikael Marttinen, Laura Turner, Teemu Natunen, Petra Mäkinen, Fanni Haapalinna, Timo Sarajärvi, Sami Gabbouj, Mitja Kurki, Jussi Paananen, Anne M. Koivisto, Tuomas Rauramaa, Ville Leinonen, Heikki Tanila, Hilkka Soininen, Fiona R. Lucas, Annakaisa Haapasalo, Mikko Hiltunen
Journal:
Journal of Cell Science
J Cell Sci (2016) 129 (11): 2224–2238.
Published: 1 June 2016
... ABSTRACT Dysfunction and loss of synapses are early pathogenic events in Alzheimer's disease. A central step in the generation of toxic amyloid-β (Aβ) peptides is the cleavage of amyloid precursor protein (APP) by β-site APP-cleaving enzyme (BACE1). Here, we have elucidated whether downregulation of septin...
Includes: Supplementary data